{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:59:22Z","timestamp":1783508362940,"version":"3.55.0"},"reference-count":8,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:p>A double blind multicentre study comparing sodium cromoglycate (600 mg\/100 ml) by enema with prednisolone (20 mg\/100 ml) by enema is reported. The study was conducted over a nine week period in the treatment of 70 patients with ulcerative colitis. Analysis of symptoms showed significant decreases in scores for patients in both groups, both at four and eight weeks; the only difference between the two groups was a significantly greater improvement in the reduction of rectal bleeding after four weeks in the prednisolone group. On sigmoidoscopy, both treatment groups showed a highly significant improvement after four and eight weeks with no significant differences being seen between the groups. Histology of the rectal biopsies showed a significant improvement in the inflammation of the mucosa for both treatment groups after four and eight weeks with no differences being observed between the groups. There were no significant changes in eosinophils from baseline and no difference between the groups at four and eight weeks.<\/jats:p>","DOI":"10.1136\/gut.28.1.88","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"88-92","source":"Crossref","is-referenced-by-count":33,"title":["Comparative trial of sodium cromoglycate enemas with prednisolone enemas in the treatment of ulcerative colitis."],"prefix":"10.1136","volume":"28","author":[{"given":"R H","family":"Grace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A E","family":"Gent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M D","family":"Hellier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1987,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/gut.16.7.559","article-title":"Disodium cromoglycate in the treatment of chronic proctitis","volume":"16","author":"Heatley, R.V.; Calcraft, B.J.; Rhodes, E.O.; Evans, B.K.","year":"1975","unstructured":"Heatley RV, Calcraft BJ, Rhodes EO, Evans BK. Disodium cromoglycate in the treatment of chronic proctitis. Gut 1975; 16: 559-63.","journal-title":"Gut"},{"key":"ref_2","first-page":"439","article-title":"Treatment of ulcerative colitis with oral disodium cromoglycate","volume":"1","author":"Mani, V.; Lloyd, G.; Green, F.H.Y.; Fox, H.; Turnberg, L.A.","year":"1976","unstructured":"Mani V, Lloyd G, Green FHY, Fox H, Turnberg LA. Treatment of ulcerative colitis with oral disodium cromoglycate. Lancet 1976; 1: 439-41.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1136\/gut.19.12.1136","article-title":"Comparative trial of sulphasalazine and oral disodium cromoglycate in the maintenance of remission in ulcerative colitis","volume":"19","author":"Dronfield, M.W.; Langman, M.J.S.","year":"1978","unstructured":"Dronfield MW, Langman MJS. Comparative trial of sulphasalazine and oral disodium cromoglycate in the maintenance of remission in ulcerative colitis. Gut 1978; 19: 1136-9.","journal-title":"Gut"},{"key":"ref_4","first-page":"119","article-title":"Comparison of disodium cromoglycate and sulphasalazine as maintenance therapy for ulcerative colitis","volume":"20","author":"Willoughby, C.P.; Piris, J.; Heyworth, M.F.; Truelove, S.C.","year":"1979","unstructured":"Willoughby CP, Piris J, Heyworth MF, Truelove SC. Comparison of disodium cromoglycate and sulphasalazine as maintenance therapy for ulcerative colitis. Lancet 1979; 20: 119-22.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1136\/gut.19.12.1140","article-title":"Controlled trial of disodium cromoglycate in chronic persistent ulcerative colitis","volume":"19","author":"Bucknell, N.A.; Gould, SR, Day; DW, Lennard-Jones; JE, Edwards; A.M.","year":"1978","unstructured":"Bucknell NA, Gould SR, Day DW, Lennard-Jones JE, Edwards AM. Controlled trial of disodium cromoglycate in chronic persistent ulcerative colitis. Gut 1978; 19: 1140-3.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/gut.22.1.55","article-title":"Disodium cromoglycate in the treatment of ulcerative colitis and Crohns disease","volume":"22","author":"Binder, V.; Elsborg, L.; Greibe, J.","year":"1981","unstructured":"Binder V, Elsborg L, Greibe J, et al. Disodium cromoglycate in the treatment of ulcerative colitis and Crohns disease. Gut 1981; 22: 55-60.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/gut.20.5.349","article-title":"Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21phosphate as a retention enema","volume":"20","author":"Lee, D.A.H.; Taylor, G.M.; Walker, J.G.; James, V.H.T.","year":"1979","unstructured":"Lee DAH, Taylor GM, Walker JG, James VHT. Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21phosphate as a retention enema. Gut 1979; 20: 349-55.","journal-title":"Gut"},{"key":"ref_8","first-page":"215","article-title":"Rectally administered prednisolone: evidence for a predominantly local action","volume-title":"Gut","volume":"21","author":"Lee, D.A.H.; Taylor, G.M.; Walker, J.G.; James, V.H.T.","year":"1980","unstructured":"Lee DAH, Taylor GM, Walker JG, James VHT. Rectally administered prednisolone: evidence for a predominantly local action. Gut 1980; 21: 215-18."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.28.1.88","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:48:45Z","timestamp":1765622925000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.28.1.88"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1987,1,1]]},"published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1136\/gut.28.1.88"],"URL":"https:\/\/doi.org\/10.1136\/gut.28.1.88","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}