{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:58:50Z","timestamp":1776247130078,"version":"3.50.1"},"reference-count":23,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:p>Bradykinin concentrations in peripheral venous blood were measured in seven patients with carcinoid syndrome. The diagnosis was based on typical symptoms and raised urinary excretion of 5-hydroxy-3-indole acetic acid; the carcinoid tumour was verified histologically. Two patients were flushing constantly and the other patients had flushing attacks two to 10 times daily. Several blood samples were taken at weekly intervals from six of seven patients. During 30 sampling procedures the patients were flushing during sampling in 12 instances. Bradykinin was measured by a sensitive solid phase radioimmunoassay technique. Blood bradykinin concentration was normal in all patients. Bradykinin is unlikely to be the vasoactive mediator of flushing.<\/jats:p>","DOI":"10.1136\/gut.28.11.1417","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1417-1419","source":"Crossref","is-referenced-by-count":22,"title":["Bradykinin in carcinoid syndrome."],"prefix":"10.1136","volume":"28","author":[{"given":"J","family":"Gustafsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Boesby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Giese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,11,1]]},"reference":[{"key":"ref_1","first-page":"109","article-title":"Pharmacologic aind endocrinc aspects ol carcinoid synidromc","volume-title":"PA, cds. 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'Ihc carcinoid syndromc"},{"key":"ref_3","first-page":"145","article-title":"Double-antibody solid phase radioimmunoaissaty lor blood bradykinin","volume":"125","author":"F, D.)armkjxr Nicisenl M.Nielsenl; AM, Kappelgaard","year":"1982","unstructured":"D)armkjxr Nicisenl M. Nielsenl F, Kappelgaard AM, (iiesc.1. Double-antibody solid phase radioimmunoaissaty lor blood bradykinin. (lin ('him Acta 1982; 125: 145-56."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/172910a0","article-title":"5-hydroxytryptamine in carcinoid tumour","volume":"172","author":"Lembeck, F.","year":"1953","unstructured":"Lembeck F. 5-hydroxytryptamine in carcinoid tumour. 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Lancet 1966; ii: 986-91.","journal-title":"Lancet"},{"key":"ref_9","article-title":"Chemistry and biology of the kallikrein-kinin system in health and disease","volume":"27","author":"C'olmann, R.W.; Wong, P.Y.; Talamno, R.C.","unstructured":"() C'olmann RW, Wong PY, Talamno RC. Chemistry and biology of the kallikrein-kinin system in health and disease. In: Pisano JJ, Austen, KF, eds. Fogartv International Center Proceedings No. 27. Washington: US","journal-title":"International Center Proceedings"},{"key":"ref_10","first-page":"487","author":"Government Printing Office","year":"1977","unstructured":"Government Printing Office, 1977: 487-94."},{"key":"ref_11","first-page":"57","article-title":"Severe hypertension and flushing in a patient with non-metastatic carcinoid tumour. A naesthesia","volume":"37","author":"Jones, R.M.; Knight, D.","year":"1982","unstructured":"Jones RM, Knight D. Severe hypertension and flushing in a patient with non-metastatic carcinoid tumour. 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Regul Peptides 1984; 9: 245-57.","journal-title":"Regul Peptides"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.28.11.1417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:56:04Z","timestamp":1765641364000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.28.11.1417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":23,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1987,11,1]]},"published-print":{"date-parts":[[1987,11]]}},"alternative-id":["10.1136\/gut.28.11.1417"],"URL":"https:\/\/doi.org\/10.1136\/gut.28.11.1417","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}