{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:10:58Z","timestamp":1765638658969,"version":"3.48.0"},"reference-count":20,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:p>The effect of olsalazine on stool output and the transit of a solid radiolabelled meal through the stomach, small intestine and colon was studied in six patients with ulcerative colitis intolerant of sulphasalazine. Olsalazine 250 mg four times daily significantly accelerated gastric emptying (mean +\/- SD; 45.3 +\/- 24.2 min v 67.3 +\/- 33.1 min, p less than 0.05), mouth to caecum transit time (242 +\/- 41 min v 325 +\/- 33 min, p less than 0.02) and whole gut transit time (60.5 +\/- 26 h v 37.8 +\/- 17.8 h, p less than 0.05). No significant changes were seen in mean daily stool weight (215 +\/- 41 g v 162 +\/- 62 g) and mean daily stool frequency (2.2 +\/- 0.6 v 2.4 +\/- 1.8). None of these patients developed diarrhoea, but acceleration of gastric and intestinal transit may be responsible for the diarrhoea reported in some patients taking this drug.<\/jats:p>","DOI":"10.1136\/gut.28.11.1474","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1474-1477","source":"Crossref","is-referenced-by-count":25,"title":["Influence of olsalazine on gastrointestinal transit in ulcerative colitis."],"prefix":"10.1136","volume":"28","author":[{"given":"S S","family":"Rao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N W","family":"Read","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C D","family":"Holdsworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,11,1]]},"reference":[{"key":"ref_1","first-page":"892","article-title":"I Azat Khain ALl. Pins.l. Truclovc SC'. An cxpcrilicnit to dctcrniiniic thc activc nioicty of sulphasalazinc","volume":"ii:","year":"1977","unstructured":"I Azat Khain ALl. Pins.l. Truclovc SC'. An cxpcrilicnit to dctcrniiniic thc activc nioicty of sulphasalazinc. Lancet 1977; ii: 892-95.","journal-title":"Lancet"},{"key":"ref_2","first-page":"632","article-title":"Effect of sulphapyridine, 5-aminosalicylic acid and placebo in patients with idiopathic proctitis: a study to determine the active therapeutic moiety of sulphasalazine","volume":"21","author":"van Hees PAM; JH, Bakker; van Tongeren JHM","year":"1980","unstructured":"van Hees PAM, Bakker JH, van Tongeren JHM. Effect of sulphapyridine, 5-aminosalicylic acid and placebo in patients with idiopathic proctitis: a study to determine the active therapeutic moiety of sulphasalazine. 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Clinical experience of the tolerance of Mesalazine and Olsalazine in patients intolerant of Sulphasalazine. Scand J Gastroenterol 1987; 22: 332-6.","journal-title":"Scand J Gastroenterol"},{"key":"ref_7","first-page":"409","article-title":"Sulfasalazine induced exacerbation of ulcerative colitis","volume":"306","author":"Schwartz, A.G.; Targen, SR, Saxon; A, Weinstein; W.M.","year":"1983","unstructured":"Schwartz AG, Targen SR, Saxon A, Weinstein WM. Sulfasalazine induced exacerbation of ulcerative colitis. N Engl J Med 1983; 306: 409-12.","journal-title":"N Engl J Med"},{"key":"ref_8","first-page":"43","article-title":"Sulphasalazine induced colitis complicating idiopathic ulcerative colitis","volume":"131","author":"Ring, F.A.; Herschfield, M.B.; Machin, G.A.; Scott, R.B.","year":"1984","unstructured":"Ring FA, Herschfield MB, Machin GA, Scott RB. Sulphasalazine induced colitis complicating idiopathic ulcerative colitis. Can Med AssocJ 1984; 131: 43-5.","journal-title":"Can Med AssocJ"},{"key":"ref_9","first-page":"1276","article-title":"Transit of a meal through the stomach, small intestine and colon in normal subjects and its role","volume-title":"the pathogenesis of diarrhoea. Gastroenterology 1980; 79","author":"Read, N.W.; Miles, C.A.; Fisher, D.","unstructured":"Read NW, Miles CA, Fisher D, et al. Transit of a meal through the stomach, small intestine and colon in normal subjects and its role in the pathogenesis of diarrhoea. Gastroenterology 1980; 79: 1276-82."},{"key":"ref_10","first-page":"405","article-title":"CD. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns","volume":"24","author":"Cann, P.A.","year":"1983","unstructured":"Cann PA, Read NW, Brown C, Hobson N, Holdsworth CD. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns. CGlt 1983; 24: 405-1 1.","journal-title":"CGlt"},{"key":"ref_11","article-title":"The cffect of disodium azodisalicylate (DSA) on water aind electrolyte trainsfer of the rat ileum and colon in vivo compared with sulfasalazine (SASP), 5-a1mino salicylic acid","volume-title":"(SA) and Sulfapyridine. Gastroenterology 1984; 86: 1091","author":"Goerg, K.J.; Breilitig, Wanitschke R.; K, Franke; M.","unstructured":"Goerg KJ, Wanitschke R. Breilitig K, Franke M. The cffect of disodium azodisalicylate (DSA) on water aind electrolyte trainsfer of the rat ileum and colon in vivo compared with sulfasalazine (SASP), 5-a1mino salicylic acid (SA) and Sulfapyridine. Gastroenterology 1984; 86: 1091."},{"key":"ref_12","first-page":"1306","article-title":"Scandberg-Gertzen H1 Jarnerot","volume-title":"Effect ot alzodisail sodiulil and sulphasalazine on ileostomV OLItpLut of fluid, PGE, and PGF2, in suLbjects with a permainent ileostonixy","volume":"27","author":"J.","year":"1986","unstructured":"Scandberg-Gertzen H1 Jarnerot G, BLukhaive K, Lauritsen K, Rask-Madsen J. Effect ot alzodisail sodiulil and sulphasalazine on ileostomV OLItpLut of fluid, PGE, and PGF2, in suLbjects with a permainent ileostonixy. (Glt 1986; 27: 1306-1 1."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/0016-5085(78)90246-9","article-title":"Capacity ot humnan colon to absorb fluid","volume":"74","author":"Debongnie, J.C.; Phillips, S.F.","year":"1978","unstructured":"Debongnie JC, Phillips SF. Capacity ot humnan colon to absorb fluid. 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Whtat is ulceriative colitis'? Lancet 1954; i: 159-60.","journal-title":"Lancet"},{"issue":"3","key":"ref_19","first-page":"201","article-title":"Observations on idiopaithic procitis","volume":"1962","author":"Lennard-Jones, J.E.; Cooper, G.W.; Newell, A.C.; Wilson, C.W.E.; Avcry Jones, F.","unstructured":"Lennard-Jones JE, Cooper GW, Newell AC, Wilson CWE, Avcry Jones F. Observations on idiopaithic procitis. Gult 1962; 3: 201-6.","journal-title":"Gult"},{"key":"ref_20","first-page":"688","article-title":"Faccal stasis aind diverticular discase in ulcerative colitis","volume":"11","author":"Jalan, K.N.; Walker, R.J.; Prescott, R.J.; S1TG, Buttcrworth; Smith, A.N.; Sircus, W.","year":"1970","unstructured":"Jalan KN, Walker RJ, Prescott RJ, Buttcrworth S1TG, Smith AN, Sircus W. Faccal stasis aind diverticular discase in ulcerative colitis. 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