{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:52:14Z","timestamp":1782827534442,"version":"3.54.5"},"reference-count":11,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:p>Oesophageal manometry and 24 hour ambulatory pH recordings from the distal oesophagus were carried out in 25 patients with complications of oesophagitis (stricture, Barrett's oesophagus or oesophageal ulcer) and compared with 25 patients with uncomplicated oesophagitis. Acid reflux was more severe in the complicated group with 26.2% of time below pH 4 compared with 11.3% in uncomplicated patients (p less than 0.01). This difference was most marked at night, when complicated patients had long periods of acid reflux with 35.6% time less than pH 4 compared with 5.2% uncomplicated (p less than 0.001). The mean duration of nocturnal acid reflux was 15.4 minutes (2.1 minutes uncomplicated, p less than 0.001). Oesophageal motility was markedly abnormal in all groups, but with no demonstrable differences in lower oesophageal sphincter pressure or peristalsis between the groups. Patients with complications of oesophagitis have different patterns of acid reflux from uncomplicated patients, with prolonged nocturnal bathing of the oesophageal mucosa, which may be the cause of stricture formation, metaplasia, or ulceration.<\/jats:p>","DOI":"10.1136\/gut.28.11.1484","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1484-1488","source":"Crossref","is-referenced-by-count":99,"title":["Patterns of acid reflux in complicated oesophagitis."],"prefix":"10.1136","volume":"28","author":[{"given":"D","family":"Robertson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Aldersley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C L","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1987,11,1]]},"reference":[{"key":"ref_1","first-page":"376","volume-title":"Pathogenesis of reflux oesophagitis. Gastroenterology 1981; 81","author":"WJ, I.Dodds; WJ, Hogan; JF, Helm; J, Dent","unstructured":"I Dodds WJ, Hogan WJ, Helm JF, Dent J. Pathogenesis of reflux oesophagitis. Gastroenterology 1981; 81: 376-9."},{"key":"ref_2","first-page":"732","article-title":"Acid clearing from the distal ocsophagus","volume":"76","author":"Booth, D.J.; Kemmerer, W.D.; Skinner, D.B.","year":"1968","unstructured":"Booth DJ, Kemmerer WD, Skinner DB. Acid clearing from the distal ocsophagus. Arch Sulrg 1968; 76: 732-4.","journal-title":"Arch Sulrg"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/gut.25.1.7","article-title":"Motility of the distal ocsophagus and gastro-oesophageal reflux","volume":"25","author":"Corraziari, E.; Bontemp, I.; Anzini, F.; Torsoli, A.","year":"1984","unstructured":"Corraziari E, Bontemp I, Anzini F, Torsoli A. Motility of the distal ocsophagus and gastro-oesophageal reflux. 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Gastroenterology 1986; 91: 879-904."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJM198212163072503","article-title":"Mechanisms ot gastrocsophageal reflux in patients with reflux oesophagitis","volume":"307","author":"Dodds, W.J.; Dcnt, J.; Hogan, W.J.","year":"1982","unstructured":"Dodds WJ, Dcnt J, Hogan WJ. Mechanisms ot gastrocsophageal reflux in patients with reflux oesophagitis. N Engl J Med 1982; 307: 1547-52.","journal-title":"N Engl J Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/gut.28.8.946","article-title":"antagonists in the trcatmcnt of rcflux oesophagitis: can physiological studies predict the response?","volume":"28","author":"Robertson, D.A.F.; Aldersley, M.; Shepherd, H.; Lloyd, R.; H, Smith C.L.","year":"1987","unstructured":"Robertson DAF, Aldersley M, Shepherd H, Lloyd R, Smith CL. H, antagonists in the trcatmcnt of rcflux oesophagitis: can physiological studies predict the response? Gut 1987; 28: 946-9.","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0016-5085(86)80017-8","article-title":"Healing and relapse of reflux oesophagitis during treatment with ranitidine","volume":"91","author":"Koelz, H.R.; Birchler, R.; Bretholz, A.","year":"1986","unstructured":"Koelz HR, Birchler R, Bretholz A, et al. Healing and relapse of reflux oesophagitis during treatment with ranitidine. Gastroenterology 1986; 91: 1198-205.","journal-title":"Gastroenterology"},{"key":"ref_9","article-title":"In: The esophagus","author":"Savary, M.; Miller, G.","year":"1978","unstructured":"Savary M, Miller G. In: The esophagus. Switzerland: Gassmann, 1978."},{"key":"ref_10","first-page":"1160","article-title":"The role of prolonged esophageal pH monitoring in the diagnosis of gastroesophageal reflux. JA","volume":"252","author":"Fink, S.M.; McCallum, R.W.","year":"1984","unstructured":"Fink SM, McCallum RW. The role of prolonged esophageal pH monitoring in the diagnosis of gastroesophageal reflux. JA MA 1984; 252: 1160-4."},{"key":"ref_11","first-page":"1582","article-title":"Dilatation of peptic oesophageal strictures: is it really beneficial?","volume":"90","author":"Penagini, R.; Evans, P.F.; Trotman, I.F.","year":"1986","unstructured":"Penagini R, Evans PF, Trotman IF. Dilatation of peptic oesophageal strictures: is it really beneficial? Gastroenterology 1986; 90: 1582.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.28.11.1484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T11:35:22Z","timestamp":1765625722000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.28.11.1484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":11,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1987,11,1]]},"published-print":{"date-parts":[[1987,11]]}},"alternative-id":["10.1136\/gut.28.11.1484"],"URL":"https:\/\/doi.org\/10.1136\/gut.28.11.1484","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}