{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:01:14Z","timestamp":1791475274625,"version":"4.3.4"},"reference-count":25,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987,2]]},"abstract":"<jats:p>The effect of an infusion of two doses of peptide YY (PYY), a novel putative gastrointestinal hormone, has been assessed on mouth to caecum intestinal transit time and on the rate of gastric emptying after ingestion of an inert 200 ml liquid meal thought unlikely to interrupt fasting gastrointestinal motility patterns. A low dose of PYY was chosen to give plasma concentrations within the range seen postprandially in healthy subjects, while the high dose mimicked the raised levels seen in several malabsorptive conditions. During infusion of PYY at 0.18 pmol\/kg\/min plasma concentrations rose from a basal of 8 +\/- 2 pmol\/l to 38 +\/- 5 pmol\/l and at 0.51 pmol\/kg\/min to 87 +\/- 10 pmol\/l. Mouth to caecum transit time was delayed from 67 +\/- 4 mins on the saline infusion day to 94 +\/- 7 mins (p less than 0.01) on the low dose and 192 +\/- 9 mins (p less than 0.001) on the high dose infusion day. Time to 50% gastric emptying was prolonged from 37 +\/- 8 mins during saline infusion to 63 +\/- 10 mins (p less than 0.05) during low and 130 +\/- 12 mins (p less than 0.001) during high dose infusion. Thus the infusion of PYY shows a dose related inhibition of mouth to caecum intestinal transit time and of the rate of gastric emptying and suggests this novel hormonal peptide to be of importance in gastrointestinal physiology.<\/jats:p>","DOI":"10.1136\/gut.28.2.166","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"166-170","source":"Crossref","is-referenced-by-count":283,"title":["Effects of peptide YY (PYY) on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers."],"prefix":"10.1136","volume":"28","author":[{"given":"A P","family":"Savage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T E","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Carolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V K","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S R","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1987,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/285417a0","article-title":"Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides","volume":"285","author":"Tatemoto, K.; Mutt, V.","year":"1980","unstructured":"Tatemoto K, Mutt V. Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Nature 1980; 285: 417-8.","journal-title":"Nature"},{"key":"ref_2","first-page":"2514","article-title":"Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits","volume-title":"pancreatic exocrine secretion. Proc Natl Acad Sci USA","volume":"79","author":"Tatemoto, K.","year":"1982","unstructured":"Tatemoto K. Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci USA 1982; 79: 2514-8."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/296659a0","article-title":"Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide","volume":"296","author":"Tatemoto, K.; Carlquist, M.; Mutt, V.","year":"1982","unstructured":"Tatemoto K, Carlquist M, Mutt V. Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 1982; 296: 659-60.","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2220\/biomedres.4.289","article-title":"Immunocytochemical demonstration of polypeptide YY (PYY) in the gastrointestinal tract of the monkey, macaca rhesus: light and electron microscopic study","volume":"4","author":"El-Salhy, M.; Grimelius, L.","year":"1983","unstructured":"El-Salhy M, Grimelius L. Immunocytochemical demonstration of polypeptide YY (PYY) in the gastrointestinal tract of the monkey, macaca rhesus: light and electron microscopic study. 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Peptide YY (PYY) immunoreactivity is co-stored with glucagonrelated immunoreactants in endocrine cells of the gut and pancreas. Histochemistry 1984; 80: 487-91.","journal-title":"Histochemistry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0167-0115(84)90034-X","article-title":"Co-existence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut","volume":"8","author":"Bottcher, G.; Sjolund, K.; Ekblad, E.; Hakanson, R.; Schwartz, T.W.; Sundler, F.","year":"1984","unstructured":"Bottcher G, Sjolund K, Ekblad E, Hakanson R, Schwartz TW, Sundler F. Co-existence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut. Regul Pept 1984; 8: 261-6.","journal-title":"Regul Pept"},{"key":"ref_8","first-page":"1070","article-title":"Human distribution and release of a putative new gut hormone","volume-title":"peptide YY (PYY). 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Acta Chir Scand 1967; 133: 407-16.","journal-title":"Acta Chir Scand"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.28.2.166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T16:57:36Z","timestamp":1765645056000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.28.2.166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,2]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1987,2,1]]},"published-print":{"date-parts":[[1987,2]]}},"alternative-id":["10.1136\/gut.28.2.166"],"URL":"https:\/\/doi.org\/10.1136\/gut.28.2.166","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,2]]}}}