{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:57:51Z","timestamp":1792443471635,"version":"4.5.0"},"reference-count":24,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:p>This study has identified a group of patients with inflammatory chronic, or relapsing acute arthritis who even in the absence of gastrointestinal symptoms have histological evidence of ileocolitis. At colonoscopy simultaneous biopsies of the terminal ileum and colon were taken from 108 patients with reactive arthritis (n = 55) or ankylosing spondylitis (n = 53), 47 patients with other rheumatic diseases and 19 control patients suffering from colonic polyps, adenocarcinoma, or chronic constipation. All control patients and all but one patient with rheumatoid arthritis, juvenile chronic arthritis, systemic lupus erythematosus, lumbar back ache, and psoriatic arthritis did not have histological evidence of acute or chronic inflammatory bowel disease. In contrast, in 30 of 35 (56.6%) patients with ankylosing spondylitis, and in 37 of 55 (67%) patients with reactive arthritis, regardless of HLA B27 phenotype, there was histological evidence of inflammatory bowel disease with features either of acute enterocolitis, or early Crohn's disease. Only 18 of 67 (27%) of the patients with histological gut inflammation, however, had intestinal symptoms.<\/jats:p>","DOI":"10.1136\/gut.28.4.394","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"394-401","source":"Crossref","is-referenced-by-count":129,"title":["Histopathology of intestinal inflammation related to reactive arthritis."],"prefix":"10.1136","volume":"28","author":[{"given":"C","family":"Cuvelier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Barbatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Mielants","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Roels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Veys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1987,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/ard.29.5.483","article-title":"Arthritis associated with salmonella infections","volume":"29","author":"CPW, I.Warren","year":"1970","unstructured":"I Warren CPW. Arthritis associated with salmonella infections. Ann Rheum Dis 1970; 29: 483-7.","journal-title":"Ann Rheum Dis"},{"key":"ref_2","first-page":"693","article-title":"An 'experimental epidemic' of Reiter's syndrome","author":"Moer, H.R.","year":"1966","unstructured":"Moer HR. An 'experimental epidemic' of Reiter's syndrome. JAMA 1966; 198: 693-8.","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/art.1780170505","article-title":"HLA-B27 in reactive arthritis. A study of yersinia arthritis and Reiter's disease","volume":"17","author":"Aho, K.; Ahvonen, P.; Lassus, A.; Sievers, K.; Tiilikainen, A.","year":"1974","unstructured":"Aho K, Ahvonen P, Lassus A, Sievers K, Tiilikainen A. HLA-B27 in reactive arthritis. A study of yersinia arthritis and Reiter's disease. Arthritis Rheum 1974; 17: 521-6.","journal-title":"Arthritis Rheum"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1136\/bmj.1.6160.380-a","article-title":"Reactive arthritis associated with campylobacter jejuni enteritis","volume":"1","author":"Berdun, J.H.; Muyntjens, H.L.; Van de Putte, L.B.","year":"1979","unstructured":"Berdun JH, Muyntjens HL, Van de Putte LB. Reactive arthritis associated with campylobacter jejuni enteritis. Br Med J 1979; 1: 380-1.","journal-title":"Br Med J"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1056\/NEJM198312293092604","article-title":"Reiter's syndrome and reactive arthritis in perspective","volume":"309","author":"Keat, A.","year":"1983","unstructured":"Keat A. Reiter's syndrome and reactive arthritis in perspective. N EnglJ Med 1983; 309: 1606-15.","journal-title":"N EnglJ Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/bmj.2.5463.670","article-title":"The arthritis of ulcerative colitis","volume":"2","author":"Wright, V.; Watkinson, G.","year":"1965","unstructured":"Wright V, Watkinson G. The arthritis of ulcerative colitis. Br Med J 1965; 2: 670-80.","journal-title":"Br Med J"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00005792-197305000-00003","article-title":"The musculo-skeletal complications of Crohn's disease","volume":"52","author":"Haslock 1, Wright V","year":"1973","unstructured":"Haslock 1, Wright V. The musculo-skeletal complications of Crohn's disease. Medicine 1973; 52: 217-25.","journal-title":"Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1056\/NEJM197405162902004","article-title":"HLA-W27 - A useful discriminator in the arthropathies of inflammatory bowel disease","volume":"290","author":"Morris, R.I.; Metzger, A.L.; Bluestone, R.; Terasaki, P.I.","year":"1974","unstructured":"Morris RI, Metzger AL, Bluestone R, Terasaki PI. HLA-W27 - A useful discriminator in the arthropathies of inflammatory bowel disease. N EnglJ Med 1974; 290: 1117-19.","journal-title":"N EnglJ Med"},{"key":"ref_9","first-page":"904","article-title":"Ankylosing spondylitis and HLAW27","volume":"i:","author":"Brewerton, D.A.; Hart, F.D.; Nicholls, A.; Caffrey, M.; James, D.C.O.; Sturrock, R.D.","year":"1973","unstructured":"Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DCO, Sturrock RD. Ankylosing spondylitis and HLAW27. Lancet 1973; i: 904-7.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1056\/NEJM197304052881403","article-title":"High association of an HLA antigen, W27, with ankylosing spondylitis","volume":"288","year":"1973","unstructured":"High association of an HLA antigen, W27, with ankylosing spondylitis. N EnglJ Med 1973; 288: 704-6.","journal-title":"N EnglJ Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/ard.38.Suppl_1.84","article-title":"Persistent yet reversible asymmetric pauciarthritis: a B27 associated cluster","volume":"38","author":"Bitter, T.; Jeannet, E.; de Haller, E.; Lejeune, M.","year":"1979","unstructured":"Bitter T, Jeannet E, de Haller E, Lejeune M. Persistent yet reversible asymmetric pauciarthritis: a B27 associated cluster. Ann Rheum Dis 1979; suppl. 38: 84-91.","journal-title":"Ann Rheum Dis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/ard.35.6.531","article-title":"HLA-B27 antigen in diagnosis of atypical seronegative inflammatory arthropathy","volume":"35","author":"Joliat, G.; Penro, A.; Jeannet, M.; Ott, H.","year":"1976","unstructured":"Joliat G, Penro A, Jeannet M, Ott H. HLA-B27 antigen in diagnosis of atypical seronegative inflammatory arthropathy. Ann Rheum Dis 1976; 35: 531-3.","journal-title":"Ann Rheum Dis"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/ard.39.3.231","article-title":"Seronegative pauciarticular arthritis and HLA-B27","volume":"39","author":"Eastmond, C.J.; Rayah, S.M.; Tovey, D.; Wright, V.","year":"1980","unstructured":"Eastmond CJ, Rayah SM, Tovey D, Wright V. Seronegative pauciarticular arthritis and HLA-B27. Ann Rheum Dis 1980; 39: 231-4.","journal-title":"Ann Rheum Dis"},{"key":"ref_14","first-page":"11","article-title":"Rhumatismes inflammatoires inclassables avec HLA-B27","volume":"49","author":"Meyer 0, Vignolli M, Ryckewaert A","year":"1982","unstructured":"Meyer 0, Vignolli M, Ryckewaert A. Rhumatismes inflammatoires inclassables avec HLA-B27. Rev Rhum Mal Osteoartic 1982; 49: 11-16.","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"ref_15","first-page":"640","article-title":"HLA-B27 related 'unclassifiable' seronegative spondyloarthropathies","volume":"42","author":"Prakash, S.; Mehra, N.K.; Bhancava, S.; Malaviya, A.N.","year":"1982","unstructured":"Prakash S, Mehra NK, Bhancava S, Malaviya AN. HLA-B27 related 'unclassifiable' seronegative spondyloarthropathies. Ann Rheum Dis 1982; 42: 640-3.","journal-title":"Ann Rheum Dis"},{"key":"ref_16","first-page":"293","article-title":"HLA-B27 related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histology in patients with HLA-B27 related arthritis","volume":"12","author":"Mielants, H.; Veys, E.; Cuvelier, C.; De Vos, M.; Botelberghe, L.","year":"1985","unstructured":"Mielants H, Veys E, Cuvelier C, De Vos M, Botelberghe L. HLA-B27 related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histology in patients with HLA-B27 related arthritis. J Rheumatol 1985; 12: 293-8.","journal-title":"J Rheumatol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/gut.26.9.945","article-title":"Campylobacter colitis: Histological, immunohistochemical and ultrastructural findings","volume":"26","author":"JP, Van Spreeuwel; GG, Duursma; CJLM, Meijer; R, Bax; PCM, Rosekrans; J, Lindeman","year":"1985","unstructured":"Van Spreeuwel JP, Duursma GG, Meijer CJLM, Bax R, Rosekrans PCM, Lindeman J. Campylobacter colitis: Histological, immunohistochemical and ultrastructural findings. Gut 1985; 26: 945-51.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/ajcp\/67.6.550","article-title":"Microgranulomas in grossly normal rectal mucosa in Crohn's disease","volume":"67","author":"Rotterdam, H.; Korelitz, B.I.; Sommers, S.C.","year":"1977","unstructured":"Rotterdam H, Korelitz BI, Sommers SC. Microgranulomas in grossly normal rectal mucosa in Crohn's disease. Am J Clin Pathol 1977; 67: 550-4.","journal-title":"Am J Clin Pathol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/ajcp\/71.6.631","article-title":"The histopathology of enteric infection with Yersinia pseudotuberculosis","volume":"71","author":"El-Maraghi, N.R.H.; Mair, N.S.","year":"1979","unstructured":"El-Maraghi NRH, Mair NS. The histopathology of enteric infection with Yersinia pseudotuberculosis. Am J Clin Pathol 1979; 71: 631-9.","journal-title":"Am J Clin Pathol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0016-5085(77)80076-0","article-title":"Yersinia enteritis and enterocolitis","volume":"72","author":"Vantrappen, G.; Agg, H.O.; Ponette, E.; Geboes, K.; Bertrand, T.H.","year":"1977","unstructured":"Vantrappen G, Agg HO, Ponette E, Geboes K, Bertrand TH. Yersinia enteritis and enterocolitis. Gastroenterology 1977; 72: 220-7.","journal-title":"Gastroenterology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00004836-198003000-00003","article-title":"The 'early' ulcerative lesion of Crohn's disease: correlative lightand scanning electron-microscopic studies","volume":"2","author":"Rickert, R.R.; Carter, H.W.","year":"1980","unstructured":"Rickert RR, Carter HW. The 'early' ulcerative lesion of Crohn's disease: correlative lightand scanning electron-microscopic studies. J Clin Gastroenterol 1980; 2: 11-19.","journal-title":"J Clin Gastroenterol"},{"key":"ref_22","first-page":"328","article-title":"Granulomatous ileocolitis preceded by three years of pauciarticular arthritis","volume":"69","author":"Smith, M.C.; Barker, J.D.","year":"1978","unstructured":"Smith MC, Barker JD. Granulomatous ileocolitis preceded by three years of pauciarticular arthritis. Am J Gastroenterol 1978; 69: 328-30.","journal-title":"Am J Gastroenterol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1136\/ard.32.6.479","article-title":"Arthritis and Crohn's disease","volume":"32","author":"1, Haslock","year":"1973","unstructured":"Haslock 1. Arthritis and Crohn's disease. Ann Rheum Dis 1973; 32: 479-86.","journal-title":"Ann Rheum Dis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0140-6736(84)92739-9","article-title":"Intestinal permeability and inflammation in rheumatoid arthritis: effects of nonsteroidal anti-inflammatory drugs","volume":"ii:","author":"Bjarnason 1, So A, Levi AJ","year":"1984","unstructured":"Bjarnason 1, So A, Levi AJ, et al. Intestinal permeability and inflammation in rheumatoid arthritis: effects of nonsteroidal anti-inflammatory drugs. Lancet 1984; ii: 1171-4.","journal-title":"Lancet"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.28.4.394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T18:20:30Z","timestamp":1757269230000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.28.4.394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1987,4,1]]},"published-print":{"date-parts":[[1987,4]]}},"alternative-id":["10.1136\/gut.28.4.394"],"URL":"https:\/\/doi.org\/10.1136\/gut.28.4.394","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}