{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:36:17Z","timestamp":1757619377926,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:p>After healing of a gastric ulcer, 53 patients were randomly allocated to either 12 months maintenance treatment with ranitidine 150 mg at night or an identical placebo. Fifty patients completed the trial. The patients were interviewed every third month. If symptoms indicated a relapse, endoscopy was done; and if an ulcer was found the maintenance trial was terminated. All remaining patients were endoscoped after one year. The accumulated relapse rate in the ranitidine group (36%) was significantly lower (p less than 0.01) than in the placebo group (76%), as also was the antacid consumption (p less than 0.01). Four of the six ulcers found at the final one year endoscopy were asymptomatic. In all but two of the 26 patients with relapse of symptoms an ulcer was found at endoscopy. The patients that suffered a recurrence had significantly (p less than 0.05) higher maximal acid output than those without ulcer recurrence. The time needed for healing of the relapse ulcers (four or eight weeks) corresponded to that needed for healing of the preinclusion ulcers. It is concluded that ranitidine 150 mg at night significantly reduces the gastric ulcer recurrence rate, and that relapsing ulcers are similar to the initial ones in healing response.<\/jats:p>","DOI":"10.1136\/gut.28.4.460","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"460-463","source":"Crossref","is-referenced-by-count":19,"title":["Ranitidine 150 mg at night in the prevention of gastric ulcer relapse."],"prefix":"10.1136","volume":"28","author":[{"given":"R","family":"Jorde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Burhol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,4,1]]},"reference":[{"issue":"5","key":"ref_1","first-page":"2","article-title":"Duodenal and gastric ulcer healing rates: a review","volume":"77","author":"Legerton, C.W.","year":"1984","unstructured":"Legerton CW. Duodenal and gastric ulcer healing rates: a review. Am J Med 1984; 77: suppl 5B: 2-7.","journal-title":"Am J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3109\/00365528309182125","article-title":"Gastric ulcer healing with ranitidine and cimetidine. A multicentre study","volume":"18","author":"Baron, J.H.; Perrin, V.L.","year":"1983","unstructured":"Baron JH, Perrin VL, et al. Gastric ulcer healing with ranitidine and cimetidine. A multicentre study. Scand J Gastroenterol 1983; 18: 973-6.","journal-title":"Scand J Gastroenterol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3109\/00365528309181831","article-title":"Review. The natural history of peptic ulcer views in the 1980s","volume":"18","author":"Myren, J.","year":"1983","unstructured":"Myren J. Review. The natural history of peptic ulcer views in the 1980s. Scand J Gastroenterol 1983; 18: 993-7.","journal-title":"Scand J Gastroenterol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3109\/00365528209182081","article-title":"Relapse rates after initial ulcer healing with sucralfate and cimetidine","volume":"17","author":"Marks, I.N.; Wright, J.P.; Lucke, W.; Girdwood, A.H.","year":"1982","unstructured":"Marks IN, Wright JP, Lucke W, Girdwood AH. Relapse rates after initial ulcer healing with sucralfate and cimetidine. ScandJ Gastroenterol 1982; 17: 429-32.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_5","first-page":"659","article-title":"Ranitidine and cimetidine in prevention of duodenal ulcer relapse","volume":"ii:","author":"Gough, K.R.; Korman, M.G.; Bardhan, K.D.; Fl, Lee; Crowe, J.P.; Reed, P.I.; Smith, R.N.","year":"1984","unstructured":"Gough KR, Korman MG, Bardhan KD, Lee Fl, Crowe JP, Reed PI, Smith RN. Ranitidine and cimetidine in prevention of duodenal ulcer relapse. 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ScandJ Gastroenterol 1984; 19: 394-400.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_8","first-page":"85","article-title":"Ranitidine: prophylaxis of duodenal ulcer recurrence","volume":"31","author":"Lee, F.J.; Fielding, J.D.; Holmes, G.K.T.","year":"1984","unstructured":"Lee FJ, Fielding JD, Holmes GKT, et al. Ranitidine: prophylaxis of duodenal ulcer recurrence. HepatoGastroenterol 1984; 31: 85-7.","journal-title":"HepatoGastroenterol"},{"key":"ref_9","first-page":"853","article-title":"Effect of cimetidine treatment in the prevention of gastric ulcer relapse: a one year double blind multicentre study","volume-title":"Gut","volume":"24","author":"Hentschel, E.; Schutze, K.; Weiss, W.","year":"1983","unstructured":"Hentschel E, Schutze K, Weiss W, et al. Effect of cimetidine treatment in the prevention of gastric ulcer relapse: a one year double blind multicentre study. 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