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Recumbent exposure correlated with both upright and postprandial exposure (p less than 0.001). Acid exposure during all four periods correlated significantly with the severity of oesophagitis, but postprandial acid exposure correlated best and recumbent acid exposure least well. Although acid clearance in the total, recumbent and upright periods correlated with oesophagitis, postprandial clearance showed the closest relationship. Thus the magnitude of daytime reflux, especially postprandial reflux and acid clearance, is more closely related than nocturnal reflux to oesophagitis. The results do not support the contention that night time reflux is inherently more injurious than daytime reflux to the oesophageal mucosa.<\/jats:p>","DOI":"10.1136\/gut.28.5.519","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"519-526","source":"Crossref","is-referenced-by-count":106,"title":["Daytime gastro-oesophageal reflux is important in oesophagitis."],"prefix":"10.1136","volume":"28","author":[{"given":"J S","family":"de Caestecker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J N","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pryde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C","family":"Heading","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/bjs.1800561211","article-title":"Prolonged pH recording in the study of gastro-oesophageal reflux","volume":"56","author":"Spencer, J.","year":"1969","unstructured":"Spencer J. 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Gastroenterology 1970; 58: 163-74."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0016-5085(84)80012-8","article-title":"Barrett's esophagus: clinical, endoscopic, histologic, manometric and electrical potential difference characteristics","volume":"86","author":"Herlihy, K.J.; Orlando, R.L.; Bryson, J.C.; Bosymski, E.M.; Carney, C.N.; Powell, D.W.","year":"1984","unstructured":"Herlihy KJ, Orlando RL, Bryson JC, Bosymski EM, Carney CN, Powell DW. Barrett's esophagus: clinical, endoscopic, histologic, manometric and electrical potential difference characteristics. 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Arch Surg 1968; %: 731-4.","journal-title":"Arch Surg"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/gut.15.11.852","article-title":"Oesophageal acid clearing: one factor in the production of reflux oesophagitis","volume":"15","author":"Stanciu, C.; Bennett, JR","year":"1974","unstructured":"Stanciu C, Bennett JR. Oesophageal acid clearing: one factor in the production of reflux oesophagitis. Gut 1974; 15: 852-7.","journal-title":"Gut"},{"key":"ref_32","first-page":"1025","article-title":"Intraesophageal pH monitoring as a discriminator of esophagitis","volume-title":"children. [Abstract] Gastroenterology","volume":"86","author":"Berquist, W.; Akharjee, N.; Yonkeles, L.; Ament, M.","year":"1984","unstructured":"Berquist W, Akharjee N, Yonkeles L, Ament M. Intraesophageal pH monitoring as a discriminator of esophagitis in children. 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