{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:06:53Z","timestamp":1765638413690,"version":"3.48.0"},"reference-count":12,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987,8]]},"abstract":"<jats:p>Ambulatory oesophageal pH, oesophageal manometry and fasting serum gastrin concentrations were carried out on 28 patients with reflux oesophagitis, before and during treatment with ranitidine 300 mg bd. Fourteen patients healed endoscopically at six weeks (group A) and 14 had residual oesophagitis (group B). Group A were characterised by a lower serum gastrin concentration before treatment (4.52 pmol\/l; 2.4-10: mean and range) than group B (11.1 pmol\/l; 3.5-21: p less than 0.05) and showed a marked reduction in acid reflux on treatment to near normal values. Mean per cent time below pH4 fell from 14.9 to 4.2 in group A (p less than 0.05) but was not affected in group B (14.2-15.6, not significant). Abnormal oesophageal motility was found in 13 patients from each group. This did not inhibit the response to ranitidine, and was not improved by healing of oesophagitis.<\/jats:p>","DOI":"10.1136\/gut.28.8.946","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"946-949","source":"Crossref","is-referenced-by-count":42,"title":["H2 antagonists in the treatment of reflux oesophagitis: can physiological studies predict the response?"],"prefix":"10.1136","volume":"28","author":[{"given":"D A","family":"Robertson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Aldersley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C L","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,8,1]]},"reference":[{"issue":"79","key":"ref_1","first-page":"106","volume":"17","author":"Gastroecitcrol","year":"1982","unstructured":"Gastroecitcrol 1982:, 17: suppl 79: 106-19."},{"key":"ref_2","first-page":"611","article-title":"Effect of cimetidinie oii lower oesophagcal sphincter pressure in oesophagitis","volume":"i:","author":"JG, Goodall R.J.R.Temple","year":"1980","unstructured":"Goodall RJR. Temple JG;. Effect of cimetidinie oii lower oesophagcal sphincter pressure in oesophagitis. Br MedJ 1980;i: 611-2.","journal-title":"Br MedJ"},{"key":"ref_3","article-title":"In: The e.sophagus","author":"Savary, M.; Miller, G.","year":"1978","unstructured":"Savary M, Miller G. In: The e.sophagus. Switzerland: Gassman, 1978."},{"issue":"78","key":"ref_4","first-page":"656","article-title":"Technique, indications and clinical use of 24-hour pH monitoring","volume":"1980","author":"TR, De Meester; Cl, Wong; JA, Wernly","unstructured":"De Meester TR, Wong Cl, Wernly JA. Technique, indications and clinical use of 24-hour pH monitoring. J Thorac Cardiovasc Surg 1980: 78: 656-67.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1001\/jama.1984.03350090036019","article-title":"The role of prolonged esophageill pH mnonitoring in the diagnosis ol gastroesophageal reflux","volume":"252","author":"Fink, S.M.; McCallum, R.W.","year":"1984","unstructured":"Fink SM, McCallum RW. The role of prolonged esophageill pH mnonitoring in the diagnosis ol gastroesophageal reflux. JAMA 1984; 252: 1160-4.","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/bjs.1800710607","article-title":"A frequcncyduration index for the evaluation of armbulatory recordings of gastroesophageal rcflux","volume":"71","author":"Branicki, F.J.; Evans, D.F.; Jones, J.A.","year":"1984","unstructured":"Branicki FJ, Evans DF, Jones JA, et al. A frequcncyduration index for the evaluation of armbulatory recordings of gastroesophageal rcflux. 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Glit 1983; 24: 92 1-24.","journal-title":"Glit"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/gut.22.1.49","article-title":"Compatrison of the effects of ranitidine, cimetidine aind placebo on the 24hour intragastric acidity aind nocturnal acid secretion in piatients with duodenal Llcer","volume":"22","author":"Walt, R.P.; Male, P.-J.; Rawlings, J.; t al","year":"1981","unstructured":"Walt RP, Male P-J, Rawlings J, t al. Compatrison of the effects of ranitidine, cimetidine aind placebo on the 24hour intragastric acidity aind nocturnal acid secretion in piatients with duodenal Llcer. Giut 1981; 22: 49-54.","journal-title":"Giut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0022-5223(19)33145-9","article-title":"Motility disturbances caused by oesophagitis","volume":"50","author":"Am, Olsen; JF, Schlegel","year":"1965","unstructured":"Olsen Am, Schlegel JF. Motility disturbances caused by oesophagitis. J Thorac (Cardiovase Sulrg 1965; 50: 607-17.","journal-title":"J Thorac (Cardiovase Sulrg"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0016-5085(86)90570-6","article-title":"Eosphageal motor abnormalities in gastroesophageal reflux, and the effects of fundoplication","volume":"91","author":"Gill, R.C.; Bowes, K.L.; Murphy, P.D.; Kingma, Y.J.","year":"1986","unstructured":"Gill RC, Bowes KL, Murphy PD, Kingma YJ. Eosphageal motor abnormalities in gastroesophageal reflux, and the effects of fundoplication. Gastroeniterologsy 1986; 91: 364-9.","journal-title":"Gastroeniterologsy"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0016-5085(76)80297-1","article-title":"The mechanism of aiction of gastrin on the lower oesophagcal sphincter","volume":"70","author":"D, Rattan S.Coln; RK, Goyall","year":"1976","unstructured":"Rattan S. Coln D, Goyall RK. The mechanism of aiction of gastrin on the lower oesophagcal sphincter. Gastroenterology 1976; 70: 828-35.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.28.8.946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:04:38Z","timestamp":1765638278000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.28.8.946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,8]]},"references-count":12,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1987,8,1]]},"published-print":{"date-parts":[[1987,8]]}},"alternative-id":["10.1136\/gut.28.8.946"],"URL":"https:\/\/doi.org\/10.1136\/gut.28.8.946","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1987,8]]}}}