{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:52:23Z","timestamp":1790931143776,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","issue":"Suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987]]},"abstract":"<jats:p>Self-filling blind loops of rat jejunum exhibit hyperregenerative transformation of the mucosa. We used this experimental model to characterise mechanisms, which may occur under similar conditions in man (stagnant loop syndrome). Epithelial and subepithelial resistance were measured in the Ussing-chamber by voltage divider ratio measurements after positioning a microelectrode between epithelium and subepithelial tissue layers. In the blind loop, epithelial resistance increased from 8 +\/- 1 to 23 +\/- 1 omega cm2 and subepithelial resistance from 39 +\/- 4 to 86 +\/- 8 omega cm2 as compared with control jejunum. The increase in the subepithelial resistance was paralleled anatomically by an increase in the thickness of the subepithelial tissue layers from 63 +\/- 4 microns to 177 +\/- 19 microns. Ultrastructural analysis of the tight junction area by freeze fracture electron microscopy revealed an increase in the total junctional 'depth' in the crypts from 243 +\/- 9 nm in control jejunum to 396 +\/- 17 nm in the blind loop, while the number of horizontally oriented 'strands' remained unchanged. Villus tight junctions did not differ between blind loop and control. We interpret the alterations in the self-filling blind loop as an adaptive response of the epithelium which reduces backleakage of already absorbed electrolytes across the tight junction into the intestinal lumen. This mechanism is suitable to support the intestine in maintaining body electrolyte and water contents during cellular electrolyte malabsorption.<\/jats:p>","DOI":"10.1136\/gut.28.suppl.159","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"159-164","source":"Crossref","is-referenced-by-count":5,"title":["Adaptation of the jejunal mucosa in the experimental blind loop syndrome: changes in paracellular conductance and tight junction structure."],"prefix":"10.1136","volume":"28","author":[{"given":"J D","family":"Schulzke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fromm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Bentzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Menge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E O","family":"Riecken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1987,1,1]]},"reference":[{"key":"ref_1","first-page":"389","article-title":"Nutritive effects of food constituents on the structure and function ofthe intestine","volume":"24","author":"Riecken, E.O.; Menge, H.","year":"1977","unstructured":"Riecken EO, Menge H. Nutritive effects of food constituents on the structure and function ofthe intestine. Acta Hepatogastroenterol 1977; 24: 389-99.","journal-title":"Acta Hepatogastroenterol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF01851347","article-title":"Functional, biochemical and morphological alterations in the intestines of rats with an experimental blind loop syndrome","volume":"166","author":"Bloch, R.; Menge, H.; Lorenz-Mayer, H.; Stockert, H.G.; Riecken, E.O.","year":"1975","unstructured":"Bloch R, Menge H, Lorenz-Mayer H, Stockert HG, Riecken EO. Functional, biochemical and morphological alterations in the intestines of rats with an experimental blind loop syndrome. Res Exp Med 1975; 166: 67-78.","journal-title":"Res Exp Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/cs0560121","article-title":"Structural and functional alterations in the mucosa of self-filling blind loops in rats","volume":"56","author":"Menge, H.; Kohn, R.; Dietermann, K.H.; Lorenz-Mayer, H.; Riecken, E.O.; Robinson, J.W.L.","year":"1979","unstructured":"Menge H, Kohn R, Dietermann KH, Lorenz-Mayer H, Riecken EO, Robinson JWL. Structural and functional alterations in the mucosa of self-filling blind loops in rats. Clin Sci 1979; 56: 121-31.","journal-title":"Clin Sci"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/ajcn\/32.1.234","article-title":"The contaminated small bowel syndrome: pathogenesis, diagnosis and treatment","volume":"32","author":"Gracey, M.","year":"1979","unstructured":"Gracey M. The contaminated small bowel syndrome: pathogenesis, diagnosis and treatment. Am J Clin Nutr 1979; 32: 234-43.","journal-title":"Am J Clin Nutr"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.ph.36.030174.000411","article-title":"Ion transport by mammalian small intestine","volume":"36","author":"Schultz, S.G.; Frizzell, R.A.; Nellans, H.N.","year":"1974","unstructured":"Schultz SG, Frizzell RA, Nellans HN. Ion transport by mammalian small intestine. Annu Rev Physiol 1974; 36: 51-91.","journal-title":"Annu Rev Physiol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF01870660","article-title":"Protamine reversibly decreases paracellular cation permeability in Necturus gallbladder","volume":"87","author":"Fromm, M.; Palant, C.E.; Bentzel, C.J.; Hegel, U.","year":"1985","unstructured":"Fromm M, Palant CE, Bentzel CJ, Hegel U. Protamine reversibly decreases paracellular cation permeability in Necturus gallbladder. J Membr Biol 1985; 87: 141-50.","journal-title":"J Membr Biol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/BF00595695","article-title":"Epithelial and subepithelial contributions to transmural electrical resistance of intact rat jejunum, in vitro","volume":"405","author":"Fromm, M.; Schulzke, J.-D.; Hegel, U.","year":"1985","unstructured":"Fromm M, Schulzke J-D, Hegel U. Epithelial and subepithelial contributions to transmural electrical resistance of intact rat jejunum, in vitro. Pflugers Arch 1985; 405: 400-2.","journal-title":"Pflugers Arch"},{"key":"ref_8","first-page":"6973","article-title":"Versatile piezoelectric driver for cell puncture","volume":"384","author":"Fromm, M.; Weskamp, P.; Hegel, U.","year":"1980","unstructured":"Fromm M, Weskamp P, Hegel U. Versatile piezoelectric driver for cell puncture. Pflugers Arch 1980; 384: 6973.","journal-title":"Pflugers Arch"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1152\/ajpcell.1980.239.3.C75","article-title":"Cytoplasmic regulation of tight junction permeability: effect of plant cytokinins","volume":"239","author":"Bentzel, C.J.; Hainau, B.; Ho, S.","year":"1980","unstructured":"Bentzel CJ, Hainau B, Ho S, et al. Cytoplasmic regulation of tight junction permeability: effect of plant cytokinins. Am J Physiol 1980; 239: C75-89.","journal-title":"Am J Physiol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF00583943","article-title":"Rapid determination of intraepithelial resistance barriers by alternating current spectroscopy. II. Test of model circuits and quantification of results","volume":"402","author":"Kottra, G.; Fr6mter, E.","year":"1984","unstructured":"Kottra G, Fr6mter E. Rapid determination of intraepithelial resistance barriers by alternating current spectroscopy. II. Test of model circuits and quantification of results. Pflugers Arch 1984; 402: 421-32.","journal-title":"Pflugers Arch"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1083\/jcb.96.3.693","article-title":"Participation of plasma membrane proteins in the formation of tight junctions by cultured epithelial cells","volume":"96","author":"Griepp, E.B.; Dolan, W.J.; Robbins, E.S.; Sabatini, D.D.","year":"1983","unstructured":"Griepp EB, Dolan WJ, Robbins ES, Sabatini DD. Participation of plasma membrane proteins in the formation of tight junctions by cultured epithelial cells. J Cell Biol 1983; 96: 693-703.","journal-title":"J Cell Biol"},{"key":"ref_12","first-page":"275","article-title":"Cellular regulation of tight junction permeability in a resorptive epithelium. In: Mechanisms of intestinal secretion","author":"Bentzel, C.J.; Hainau, B.O.","year":"1979","unstructured":"Bentzel CJ, Hainau BO. Cellular regulation of tight junction permeability in a resorptive epithelium. In: Mechanisms of intestinal secretion. New York: Liss Inc, 1979: 275-86."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.28.Suppl.159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T12:30:18Z","timestamp":1765629018000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.28.Suppl.159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987]]},"references-count":12,"journal-issue":{"issue":"Suppl","published-online":{"date-parts":[[1987,1,1]]},"published-print":{"date-parts":[[1987]]}},"alternative-id":["10.1136\/gut.28.Suppl.159"],"URL":"https:\/\/doi.org\/10.1136\/gut.28.suppl.159","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987]]}}}