{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:12:58Z","timestamp":1771013578565,"version":"3.50.1"},"reference-count":13,"publisher":"BMJ","issue":"Suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987]]},"abstract":"<jats:p>We investigated whether chronic subcutaneous infusion of neurotensin during 14 days would affect pancreatic and gastric growth of rats. In another experiment, neurotensin (836 pmol\/kg) was injected intraperitoneally three times a day for three days in 12 rats. Thereafter, pancreatic DNA and in vitro incorporation of 3H-thymidine into pancreatic DNA was determined. Long term infusion of 282 pmol\/kg neurotensin induced an increase of pancreatic weight, DNA, and pancreatic polypeptide, whereas pancreatic protein, RNA, amylase and lipase contents were not increased. In relation to DNA, even these parameters were significantly depressed. Insulin remained unchanged. Neurotensin, therefore, caused hyperplasia of the pancreas. Intraperitoneal injection of neurotensin induced an increase of pancreatic DNA content and stimulated 3H-thymidine incorporation into DNA, whereas caerulein only augmented 3H-thymidine incorporation. Moreover, long term neurotensin infusion led to a rise in protein concentration and an increase in the thickness of the gastric antrum; antral DNA concentration was insignificantly stimulated. Neurotensin, therefore, can act as a trophic factor on pancreas and gastric antrum of the rat.<\/jats:p>","DOI":"10.1136\/gut.28.suppl.19","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"19-23","source":"Crossref","is-referenced-by-count":59,"title":["Neurotensin induces hyperplasia of the pancreas and growth of the gastric antrum in rats."],"prefix":"10.1136","volume":"28","author":[{"given":"G E","family":"Feurle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Rix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,1,1]]},"reference":[{"key":"ref_1","first-page":"285","article-title":"Organ blood flow and exocrine pancreatic function after intravenous infusion of neurotensin","author":"Baca, I.; Mittmann, U.; Feurle, G.E.; Muller, T.; Haas, M.","year":"1981","unstructured":"Baca I, Mittmann U, Feurle GE, Muller T, Haas M. Organ blood flow and exocrine pancreatic function after intravenous infusion of neurotensin. Langenbecks Arch Chir Forum 1981; 285-88.","journal-title":"Langenbecks Arch Chir Forum"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000198725","article-title":"Effect of neurotensin on exocrine pancreatic secretion in dogs","volume":"23","author":"Ba6a, I.; Feurle, G.E.; Schwab, A.; Mittmann, U.; Knauf, W.; Lehnert, T.","year":"1982","unstructured":"Ba6a I, Feurle GE, Schwab A, Mittmann U, Knauf W, Lehnert T. Effect of neurotensin on exocrine pancreatic secretion in dogs. Digestion 1982; 23: 174-83.","journal-title":"Digestion"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0167-0115(86)90069-8","article-title":"Neurotensin stimulates pancreatic exocrine secretion in rats","volume":"15","author":"Khalil, T.; Fujumura, M.; Greeley, Jr, G.H.; Townsend, Jr, C.M.; Thompson, J.C.","year":"1986","unstructured":"Khalil T, Fujumura M, Greeley, Jr GH, Townsend, Jr CM, Thompson JC. Neurotensin stimulates pancreatic exocrine secretion in rats. [Abstract]. Regul Peptides 1986; 15: 279-84.","journal-title":"Regul Peptides"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry, O.H.; NJ, Rosebrough; A, Lewis Farr; RJ, Randall","year":"1951","unstructured":"Lowry, OH, Rosebrough NJ, Lewis Farr A, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-75.","journal-title":"J Biol Chem"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/206093a0","article-title":"An improved diphenylamine method for the estimation of deoxyribonucleic acid","volume":"206","author":"Giles, K.W.; Myers, A.","year":"1965","unstructured":"Giles KW, Myers A. An improved diphenylamine method for the estimation of deoxyribonucleic acid. Nature 1965; 206: 93.","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1039\/an9669100078","article-title":"Recent developments in the measurement of nucleic acids in biological materials","volume":"91","author":"Munro, H.N.; Fleck, A.","year":"1966","unstructured":"Munro HN, Fleck A. Recent developments in the measurement of nucleic acids in biological materials. Analyst 1966; 91: 78-88.","journal-title":"Analyst"},{"key":"ref_7","first-page":"151","article-title":"Gastric and enteral pancreatic polypeptide (PP) immunoreactivity in the dog","volume":"77","author":"Feurle, G.E.; Buchler, M.; Helmstadter, V.","year":"1986","unstructured":"Feurle GE, Buchler M, Helmstadter V. Gastric and enteral pancreatic polypeptide (PP) immunoreactivity in the dog. Acta Histochem 1986; 77: 151-8.","journal-title":"Acta Histochem"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000409171","article-title":"Physiological and pathological aspects of a neuro-endocrinological principle: neurotensin","volume":"12","author":"Feurle, G.E.","year":"1984","unstructured":"Feurle GE. Physiological and pathological aspects of a neuro-endocrinological principle: neurotensin. Frontiers Horm Res 1984; 12: 157-67.","journal-title":"Frontiers Horm Res"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1002\/1097-0142(19810315)47:6+<1640::AID-CNCR2820471430>3.0.CO;2-S","article-title":"Effects of gastrointestinal hormones on pancreatic growth","volume":"47","author":"Johnson, L.R.","year":"1981","unstructured":"Johnson LR. Effects of gastrointestinal hormones on pancreatic growth. Cancer 1981; 47: 1640-5.","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0167-0115(83)90305-1","article-title":"Neurotensin interacts with carbachol, secretin, and caerulein in the stimulation of the exocrine pancreas of the rat in vitro","volume":"7","author":"Feurle, G.E.; Reinecke, M.","year":"1983","unstructured":"Feurle GE, Reinecke M. Neurotensin interacts with carbachol, secretin, and caerulein in the stimulation of the exocrine pancreas of the rat in vitro. Regulatory Peptides 1983; 7: 137-43.","journal-title":"Regulatory Peptides"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1007\/BF01920164","article-title":"Effect of pancreatic polypeptide on DNA-synthesis in the pancreas","volume":"33","author":"Greenberg, G.R.; Mitznegg, P.; Bloom, SR","year":"1977","unstructured":"Greenberg GR, Mitznegg P, Bloom SR. Effect of pancreatic polypeptide on DNA-synthesis in the pancreas. Experientia 1977; 33: 1332-3.","journal-title":"Experientia"},{"key":"ref_12","first-page":"987","article-title":"Effect of neurotensin on gastric function in man","volume":"1","author":"Blackburn, A.M.; Fletcher, D.R.; Bloom, SR, Christofides; ND, Long; RG, Fitzpatrick; ML, Baron; J.H.","year":"1980","unstructured":"Blackburn AM, Fletcher DR, Bloom SR, Christofides ND, Long RG, Fitzpatrick ML, Baron JH. Effect of neurotensin on gastric function in man. Lancet 1980; 1: 987-9.","journal-title":"Lancet"},{"key":"ref_13","first-page":"386","article-title":"Intragastric balloons causing gastric hypertrophy, G-cell hyperplasia, and raised serum gastrin levels in rats","volume":"ii:","author":"Feurle, G.E.; Tischbirek, K.; Helmstaedter, V.","year":"1982","unstructured":"Feurle GE, Tischbirek K, Helmstaedter V. Intragastric balloons causing gastric hypertrophy, G-cell hyperplasia, and raised serum gastrin levels in rats. Lancet 1982; ii: 386.","journal-title":"Lancet"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.28.Suppl.19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:10:33Z","timestamp":1765599033000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.28.Suppl.19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987]]},"references-count":13,"journal-issue":{"issue":"Suppl","published-online":{"date-parts":[[1987,1,1]]},"published-print":{"date-parts":[[1987]]}},"alternative-id":["10.1136\/gut.28.Suppl.19"],"URL":"https:\/\/doi.org\/10.1136\/gut.28.suppl.19","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987]]}}}