{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:18:25Z","timestamp":1770434305637,"version":"3.49.0"},"reference-count":12,"publisher":"BMJ","issue":"Suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1987]]},"abstract":"<jats:p>Surgical diversion of bile and pancreatic secretions to the mid small bowel has been shown to provoke increased CCK plasma concentration and growth of the pancreas in rats. This study was undertaken to investigate the effects of chronic pancreaticobiliary diversion on pancreatic morphology as well as the circulating concentrations of pancreatic polypeptide, secretin, gastrin, and CCK. Fifteen month diversion provoked 73 and 86% increases in pancreatic weight and volume (p less than 0.001). Cholecystokinin blood concentration increased by 98%, from 20.9 +\/- 5.7 pg\/ml in controls to 41.3 +\/- 5.4 after diversion (p less than 0.05), but pancreatic polypeptide, secretin, and gastrin levels were not affected. The volume of the exocrine pancreas doubled from 1104.6 +\/- 78.2 mm3 in controls to 2201.2 +\/- 229.2 (p less than 0.001), with a matching increase in interstitial tissue. On the contrary, the volume of the endocrine pancreas remained unchanged. Hyperplastic nodules developed in the exocrine pancreas, in 71% of diverted rats, but not in transected controls. We conclude from these observations that chronic diversion of bile and pancreatic juice stimulated pancreatic growth, most likely through a persistent rise of CCK plasma concentrations. Furthermore, this long lasting stimulation induced the development of exocrine pancreatic nodules.<\/jats:p>","DOI":"10.1136\/gut.28.suppl.269","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"269-273","source":"Crossref","is-referenced-by-count":27,"title":["Exocrine pancreatic nodules after longterm pancreaticobiliary diversion in rats. An effect of raised CCK plasma concentrations."],"prefix":"10.1136","volume":"28","author":[{"given":"B M","family":"Miazza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Widgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Chayvialle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nicolet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Loizeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,1,1]]},"reference":[{"key":"ref_1","first-page":"467","article-title":"Effect of pancreatico-biliary diversion (PBD) on jejunal and ileal structure and function in the rat","volume-title":"Mechanisms of intestinal adaptation","author":"Miazza, B.M.; van Hung, Levan; Vaja, S.; Dowling, R.H.","year":"1982","unstructured":"Miazza BM, Levan van Hung, Vaja S, Dowling RH. Effect of pancreatico-biliary diversion (PBD) on jejunal and ileal structure and function in the rat. In: Robinson JWL, Dowling RH, Riecken, EO, eds. Mechanisms of intestinal adaptation. Lancaster: MTP Press, 1982; 467-76."},{"key":"ref_2","first-page":"481","article-title":"Pancreatic hyperplasia after pancreatico-biliary diversion (PBD) in orallyand parenterally-fed rats","volume-title":"Mechanisms of intestinal adaptation","author":"Miazza, B.M.; van Hung, Levan; Vaja, S.; Dowling, R.H.","year":"1982","unstructured":"Miazza BM, Levan van Hung, Vaja S, Dowling RH. Pancreatic hyperplasia after pancreatico-biliary diversion (PBD) in orallyand parenterally-fed rats. In: Robinson JWL, Dowling RH, Riecken EO, eds. Mechanisms of intestinal adaptation. Lancaster: MTP Press, 1982; 481-90."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0167-0115(82)90035-0","article-title":"Are hormonal factors responsible for the intestinal and pancreatic adaptation of pancreatico-biliary diversion?","volume":"3","author":"Miazza, B.M.; Ghatei, M.; Adrian, T.E.; Bloom, SR, Dowling; R.H.","year":"1982","unstructured":"Miazza BM, Ghatei M, Adrian TE, Bloom SR, Dowling RH. Are hormonal factors responsible for the intestinal and pancreatic adaptation of pancreatico-biliary diversion? Regul Peptides 1982; 3: 77.","journal-title":"Regul Peptides"},{"issue":"20","key":"ref_4","first-page":"75","article-title":"Mechanism of pancreatic growth induced by pancreatico-biliary diversion in the rat. Inhibition by proglumide, benzotript and ranitidin","volume":"1985","author":"Miazza, B.M.; Turberg, Y.; Guillaume, P.; Hahne, W.; Chayvialle, J.A.; Loizeau, E.","unstructured":"Miazza BM, Turberg Y, Guillaume P, Hahne W, Chayvialle JA, Loizeau E. Mechanism of pancreatic growth induced by pancreatico-biliary diversion in the rat. Inhibition by proglumide, benzotript and ranitidin. Scand J Gastroenterol 1985; 20: suppl 112: 75-83.","journal-title":"Scand J Gastroenterol"},{"key":"ref_5","series-title":"Gut","first-page":"889","article-title":"Soya-induced pancreatic hypertrophy and rise of circulating cholecystokinin","volume":"23","author":"Adrian, T.E.; Pasquali, C.; Pescota, F.; Bacarese-Hamilton, A.J.; Bloom, SR","year":"1982","unstructured":"Adrian TE, Pasquali C, Pescota F, Bacarese-Hamilton AJ, Bloom SR. Soya-induced pancreatic hypertrophy and rise of circulating cholecystokinin. [Abstract]. Gut 1982; 23: A889."},{"key":"ref_6","first-page":"88","article-title":"Elevated CCK plasma concentrations during acute and chronic feeding of soybean flour","volume":"30","author":"Folsch, U.R.; Mustroph, D.; Schafmayer, A.; Becker, H.D.; Creutzfeldt, W.","year":"1984","unstructured":"Folsch UR, Mustroph D, Schafmayer A, Becker HD, Creutzfeldt W. Elevated CCK plasma concentrations during acute and chronic feeding of soybean flour. Digestion 1984; 30: 88.","journal-title":"Digestion"},{"issue":"20","key":"ref_7","first-page":"64","article-title":"Trophic effects on the pancreas of trypsin and bile salt deficiency in the small-intestinal lumen","volume":"1985","author":"McGuinness, E.E.; Morgan, R.G.H.; Wormsley, K.G.","unstructured":"McGuinness EE, Morgan RGH, Wormsley KG. Trophic effects on the pancreas of trypsin and bile salt deficiency in the small-intestinal lumen. 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Jejunal secretory effect of intraduodenal food in humans. A comparison of mixed nutrients, proteins, lipids and carbohydrates. Gastroenterology 1985; 88: 1215-22."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/0016-5085(78)90087-2","article-title":"Uneven and transient secretin release after a liquid test meal","volume":"75","author":"Pelletier, M.J.; Chayvialle, J.A.; Minaire, Y.","year":"1978","unstructured":"Pelletier MJ, Chayvialle JA, Minaire Y. Uneven and transient secretin release after a liquid test meal. Gastroenterology 1978; 75: 1124-32.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1083\/jcb.30.1.23","article-title":"Practical stereological methods for morphometric cytology","volume":"30","author":"Weibel, E.R.; Kistler, G.S.; Scherle, W.F.","year":"1966","unstructured":"Weibel ER, Kistler GS, Scherle WF. Practical stereological methods for morphometric cytology. 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