{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T13:01:09Z","timestamp":1765630869888,"version":"3.48.0"},"reference-count":14,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:p>Eleven patients with idiopathic faecal incontinence (IFI) and nine normal controls were studied with techniques of mucosal electrosensitivity and rectal distention for the quantitative assessment of anal and rectal sensation and with manometric and electromyographic tests for the assessment of anorectal motor function. The tests of motor function showed pelvic floor motor neuropathy in the patients with IFI, compared with controls, anal canal resting and voluntary contraction pressures were significantly (p less than 0.05, p less than 0.002) lower, pudendal nerve terminal motor latency and external anal sphincter fibre density were significantly (p less than 0.05, p less than 0.05) raised. The results of mucosal electrosensitivity (MES) disclosed a sensory deficit in the anal canal in patients with IFI, compared with controls, MES threshold was significantly (p less than 0.002) higher. Sensory thresholds to rectal distension were similar in the two groups. This study shows that sensory deficit of the anal canal occurs in combination with the motor neuropathy of the anal canal musculature in primary neuropathic faecal incontinence.<\/jats:p>","DOI":"10.1136\/gut.29.1.5","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"5-9","source":"Crossref","is-referenced-by-count":93,"title":["Combined sensory and motor deficit in primary neuropathic faecal incontinence."],"prefix":"10.1136","volume":"29","author":[{"given":"J","family":"Rogers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Misiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,1,1]]},"reference":[{"key":"ref_1","article-title":"Anatomy: regional and applied","author":"Last, R.J.","year":"1978","unstructured":"Last RJ, Anatomy: regional and applied. London: Churchill Livingstone, 1978."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/bjs.18004720602","article-title":"Sensory nerve-endings and sensation in the anal region of man","volume":"47","author":"Duthie, H.L.; Gairns, F.W.","year":"1960","unstructured":"Duthie HL, Gairns FW. Sensory nerve-endings and sensation in the anal region of man. Br J Surg 1960; 47: 585-94.","journal-title":"Br J Surg"},{"key":"ref_3","first-page":"179","article-title":"The relation of sensation in the anal canal to the functional anal sphincter: a possible factor in anal incontintence","volume-title":"Gut","volume":"4","author":"Duthie, H.L.; Bennett, R.C.","year":"1963","unstructured":"Duthie HL, Bennett RC. The relation of sensation in the anal canal to the functional anal sphincter: a possible factor in anal incontintence. Gut 1963; 4: 179-82."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/gut.23.4.345","article-title":"Read Maria G, Read NW. Role of anorectal sensation in preserving continence","volume":"23","year":"1982","unstructured":"Read Maria G, Read NW. Role of anorectal sensation in preserving continence. Gut 1982; 23: 345-7.","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/bjs.1800630713","article-title":"Anorectal function after major resections of the sacrum with bilateral or unilateral sacrifice of sacral nerves","volume":"63","author":"Gunterberg, B.; Kewenter, J.; Petersen, I.; Stener, B.","year":"1976","unstructured":"Gunterberg B, Kewenter J, Petersen I, Stener B. Anorectal function after major resections of the sacrum with bilateral or unilateral sacrifice of sacral nerves. BrJ Surg 1976; 63: 546-54.","journal-title":"BrJ Surg"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/bjs.1800640820","article-title":"Function of the anal sphincters following colo-anal anastomosis","volume":"64","author":"Lane, R.H.S.; Parks, A.G.","year":"1977","unstructured":"Lane RHS, Parks AG. Function of the anal sphincters following colo-anal anastomosis. Br J Surg 1977; 64: 596-9.","journal-title":"Br J Surg"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/bjs.1800730421","article-title":"New Combined sensory and motor deficit in primary neuropathicfaecal incontinence method of assessment of anal sensation in various anorectal disorders","volume":"73","author":"Roe, A.M.; Bartolo, D.C.C.; Mortensen McC, N.J.","year":"1986","unstructured":"Roe AM, Bartolo DCC, Mortensen McC NJ. New Combined sensory and motor deficit in primary neuropathicfaecal incontinence method of assessment of anal sensation in various anorectal disorders. Br J Surg 1986; 73: 310-2.","journal-title":"Br J Surg"},{"issue":"25","key":"ref_8","article-title":"Studies on anal function in continent and incontinent patients","volume":"9","author":"Ihre, T.","year":"1974","unstructured":"Ihre T. Studies on anal function in continent and incontinent patients. Scand J Gastroenterol 1974; 9: suppl 25.","journal-title":"Scand J Gastroenterol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/gut.19.1.64","article-title":"Sensibility of the rectum to distension and the anorectal distension reflex in ulcerative colitis","volume":"19","author":"Farthing, M.J.G.; Lennard-Jones, J.E.","year":"1978","unstructured":"Farthing MJG, Lennard-Jones JE. Sensibility of the rectum to distension and the anorectal distension reflex in ulcerative colitis. Gut 1978; 19: 64-9.","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0016-5085(86)90941-8","article-title":"Changes in colorectal function in severe idiopathic constipation","volume":"90","author":"Shouler, P.; Keighley, M.R.B.","year":"1986","unstructured":"Shouler P, Keighley MRB. Changes in colorectal function in severe idiopathic constipation. Gastroenterology 1986; 90: 414-20.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1056\/NEJM198405173102003","article-title":"Anorectal sensorimotor dysfunction in faecal incontinence and diabetes mellitus","volume":"310","author":"Wald, A.; Tunuguntla, A.K.","year":"1984","unstructured":"Wald A, Tunuguntla AK. Anorectal sensorimotor dysfunction in faecal incontinence and diabetes mellitus. N EnglJ Med 1984; 310: 1282-7.","journal-title":"N EnglJ Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/bjs.1800710817","article-title":"Slowed conduction in the pudendal nerves in idiopathic (neurogenic) faecal incontinence","volume":"71","author":"Kiff, E.S.; Swash, M.","year":"1984","unstructured":"Kiff ES, Swash M. Slowed conduction in the pudendal nerves in idiopathic (neurogenic) faecal incontinence. Br J Surg 1984; 71: 614-6.","journal-title":"Br J Surg"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jnnp.38.9.874","article-title":"Motor unit fibre density in the extensor digitorum communis muscle","volume":"38","author":"Stalberg, E.; Thiele, B.","year":"1975","unstructured":"Stalberg E, Thiele B. Motor unit fibre density in the extensor digitorum communis muscle. J Neurol Neurosurg Psychiatry 1975; 38: 874-80.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/jnnp.43.4.343","article-title":"Increased motor unit fibre density in the external anal sphincter muscle in anorectal incontinence; a single fibre EMG study","volume":"43","author":"Neill, M.E.; Swash, M.","year":"1980","unstructured":"Neill ME, Swash M. Increased motor unit fibre density in the external anal sphincter muscle in anorectal incontinence; a single fibre EMG study. J Neurol Neurosurg Psychiatry 1980; 43: 343-7.","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.29.1.5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T12:56:23Z","timestamp":1765630583000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.29.1.5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1988,1,1]]},"published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1136\/gut.29.1.5"],"URL":"https:\/\/doi.org\/10.1136\/gut.29.1.5","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}