{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:53:38Z","timestamp":1765598018532,"version":"3.48.0"},"reference-count":18,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:p>The prevalence and amount (hyperplasia score) of ductal mucinous hyperplasia (DMH) were estimated in 12 predetermined areas taken from 102 pancreases obtained at necropsy from patients dying of non-pancreatic diseases. The mean prevalence of DMH was 18% (213\/1206) per section and 63% (63\/102) per pancreas. Different areas of the pancreas could be stratified by amount of DMH into 'high' (hyperplasia score greater than 0.09), 'intermediate' (0.06-0.09), and 'low' (less than 0.06). There was no significant difference in either prevalence or amount of DMH with variation in ampullary or pancreatic ductal anatomy. There was significantly (p less than 0.05) less DMH adjacent to the accessory papilla when it was patent, compared with when it was not patent and the accessory duct communicated with the main pancreatic duct. The findings suggest that DMH is a proliferative response to exogenous agents which injure the pancreas, and that some areas of the pancreas are more vulnerable than others to this damage. There was no evidence that this injury was associated either with reflux, or with any particular variation in pancreatic duct anatomy. The association between DMH and occlusion of the accessory papilla may explain the susceptibility of pancreas divisum to pancreatitis.<\/jats:p>","DOI":"10.1136\/gut.29.10.1392","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1392-1396","source":"Crossref","is-referenced-by-count":9,"title":["Pancreatic ductal mucinous hyperplasia: distribution within the pancreas, and effect of variation in ampullary and pancreatic duct anatomy."],"prefix":"10.1136","volume":"29","author":[{"given":"T G","family":"Allen-Mersh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/gut.26.8.825","article-title":"What is the significance of pancreatic ductal mucinous hyperplasia?","volume":"26","author":"Allen-Mersh, T.G.","year":"1985","unstructured":"Allen-Mersh TG. What is the significance of pancreatic ductal mucinous hyperplasia? Gut 1985; 26: 825-33.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/1097-0142(19810315)47:6+<1543::AID-CNCR2820471417>3.0.CO;2-3","article-title":"An in vitro model of human pancreatic carcinogenesis","volume":"47","author":"WL, Parsa I.Marsh; AL, Sutton","year":"1981","unstructured":"Parsa I. Marsh WL, Sutton AL. An in vitro model of human pancreatic carcinogenesis. Cancer 1981; 47: 1543-51.","journal-title":"Cancer"},{"key":"ref_3","first-page":"645","article-title":"Origin of tubular complexes developing during induction of pancreatic adenocarcinoma by 7-12-dimethylbenzanthracene","volume":"90","author":"PD, Mills L.R.Webster","year":"1978","unstructured":"Mills LR. Webster PD. Origin of tubular complexes developing during induction of pancreatic adenocarcinoma by 7-12-dimethylbenzanthracene. 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Surg Gynecol Obstet 1977; 145: 105-9.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/ajcp\/77.2.137","article-title":"Hyperplastic, preneoplastic and neoplastic lesions found in 83 human pancreases","volume":"77","author":"Pour, P.M.; Sayed, Sayed S.; G.","year":"1982","unstructured":"Pour PM, Sayed S. Sayed G. Hyperplastic, preneoplastic and neoplastic lesions found in 83 human pancreases. Am J Clin Pathol 1982; 77: 137-52.","journal-title":"Am J Clin Pathol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1136\/gut.9.3.296","article-title":"A fresh approach to the pathogenesis of pancreatitis","volume":"9","author":"McCutcheon, A.D.","year":"1968","unstructured":"McCutcheon AD. A fresh approach to the pathogenesis of pancreatitis. Gut 1968; 9: 296-310.","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/archsurg.1945.01230040214001","volume":"51","author":"Pancreatitis, Rienhoff W.F.Pickrell K.L.","year":"1945","unstructured":"Rienhoff WF. Pickrell KL. Pancreatitis. Arc\/h Surg 1945; 51: 205-19.","journal-title":"Arc\/h Surg"},{"key":"ref_9","first-page":"105","article-title":"Congenital anomaly of pancreas divisum as a cause of obstructive pain and pancreatitis","volume-title":"Gut","volume":"21","author":"Cotton, P.B.","year":"1980","unstructured":"Cotton PB. Congenital anomaly of pancreas divisum as a cause of obstructive pain and pancreatitis. Gut 1980; 21: 105-14."},{"key":"ref_10","first-page":"188","article-title":"Allen-Mersh TG. The anatomical rclation between the retropancreatic bile duct and thc main pancreatic duct","volume":"65","author":"Dawson, PR","year":"1983","unstructured":"Dawson PR. Allen-Mersh TG. The anatomical rclation between the retropancreatic bile duct and thc main pancreatic duct. Ann R Coll Surg Engl 1983; 65: 188-91.","journal-title":"Ann R Coll Surg Engl"},{"key":"ref_11","article-title":"Bent DH. Statistical package for the social sciences. Ncw","author":"Nie, N.H.; Steinbrenncr, Hull C.H.Jenkins J.G.; K.","year":"1975","unstructured":"Nie NH, Hull CH. Jenkins JG. Steinbrenncr K, Bent DH. Statistical package for the social sciences. Ncw York: McGraw Hill. 1975."},{"key":"ref_12","first-page":"421","article-title":"Mayer zum Buschenfelde K-H. Pancreas divisum: predisposition to chronic pancreatitis due to chronic secretory congestion?","volume":"111","author":"Staritz, M.; Hutteroth, T.; Manns, M.","year":"1986","unstructured":"Staritz M, Hutteroth T, Manns M. Mayer zum Buschenfelde K-H. Pancreas divisum: predisposition to chronic pancreatitis due to chronic secretory congestion? 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Gastrointest Endosc 1976; 22: 206-7.","journal-title":"Gastrointest Endosc"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/jcp.35.5.544","article-title":"The significance of the sitc of origin of pancreatic exocrine carcinoma","volume":"35","author":"Allen-Mersh, T.G.","year":"1982","unstructured":"Allen-Mersh TG. The significance of the sitc of origin of pancreatic exocrine carcinoma. J Clin Pathol 1982; 35: 544-6.","journal-title":"J Clin Pathol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/bjs.18003714721","article-title":"The anatomy of the blood vessels in the region of the pancreas","volume":"37","author":"E, Falconer C.W.A.Griffiths","year":"1950","unstructured":"Falconer CWA. Griffiths E. The anatomy of the blood vessels in the region of the pancreas. 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