{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T12:42:45Z","timestamp":1772368965555,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:p>Sphincter of Oddi (SO) dysfunction is a recognised cause of postcholecystectomy pain, but a difficult condition to diagnose, requiring endoscopic biliary manometry (EBM) to confirm sphincter motor abnormalities. We have assessed quantitative cholescintigraphy in 10 postcholecystectomy (PC) patients with clinical and manometric evidence of SO dysfunction, 10 PC patients with non-biliary type abdominal pain and 10 asymptomatic PC volunteers acting as controls to determine its value as a non-invasive screening test. Quantitative 99mTc-DISIDA scans lasted 60 minutes, activity\/time curves being created by computer analysis using the entire hepatobiliary system as region-of-interest (ROI). Scintigraphic analysis demonstrated that the time in minutes to maximum counts (Tmax) was significantly increased in the SO dysfunction group compared with the non-biliary pain group and the asymptomatic volunteers (p less than 0.001). The per cent of biliary tracer emptied was also significantly less in the SO dysfunction group than either of the other groups at both 45 minutes (p less than 0.01) and 60 minutes (p less than 0.02). We conclude that quantitative cholescintigraphy may be a valuable non-invasive screening test in clinically suspected SO dysfunction.<\/jats:p>","DOI":"10.1136\/gut.29.10.1397","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1397-1401","source":"Crossref","is-referenced-by-count":38,"title":["Quantitative 99mTc-DISIDA scanning and endoscopic biliary manometry in sphincter of Oddi dysfunction."],"prefix":"10.1136","volume":"29","author":[{"given":"G M","family":"Fullarton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Allan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Hilditch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W R","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,10,1]]},"reference":[{"key":"ref_1","first-page":"306","article-title":"Functional disturbance of the choledochus","volume":"74","author":"Mirizzi, P.L.","year":"1942","unstructured":"Mirizzi PL. Functional disturbance of the choledochus. Surg Gynecol Obstet 1942; 74: 306-18.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_2","first-page":"1","article-title":"Observations on biliary pancreatic dynamics","volume-title":"a normal human. Gastroenterology 1949; 13","author":"Ryan, J.D.; Doubilet, H.; Mulholland, J.H.","unstructured":"Ryan JD, Doubilet H, Mulholland JH. Observations on biliary pancreatic dynamics in a normal human. Gastroenterology 1949; 13: 1-8."},{"key":"ref_3","first-page":"61121","article-title":"Papillitis as a cause of pancreatitis and abdominal pain","volume":"164","author":"Nardi, G.L.; Acosta, J.M.","year":"1966","unstructured":"Nardi GL, Acosta JM. Papillitis as a cause of pancreatitis and abdominal pain. 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Gastroenterology 1986; 90: 728-33."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0016-5085(82)90131-7","article-title":"Sphincter of Oddi motor activity: a comparison between patients with common bile duct stones and controls","volume":"82","author":"Toouli, J.; Geenen, J.E.; Hogan, W.J.; Dodds, W.J.; Arndorfer, R.C.","year":"1982","unstructured":"Toouli J, Geenen JE, Hogan WJ, Dodds WJ, Arndorfer RC. Sphincter of Oddi motor activity: a comparison between patients with common bile duct stones and controls. Gastroenterology 1982; 82: 111-7.","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/gut.25.3.275","article-title":"Manometric study of the sphincter of Oddi in patients with and without common bile duct stones","volume":"25","author":"Demasi, E.; Corazziari, E.; Fl, Habib","year":"1984","unstructured":"Demasi E, Corazziari E, Habib Fl, et al. Manometric study of the sphincter of Oddi in patients with and without common bile duct stones. Gut 1984; 25: 275-8.","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0016-5085(19)32264-4","article-title":"Improved infusion system for intraluminal esophageal manometry","volume":"73","author":"Arndorfer, R.C.; Stef, J.J.; Dodds, W.J.; Linehan, J.H.; Hogan, W.J.","year":"1977","unstructured":"Arndorfer RC, Stef JJ, Dodds WJ, Linehan JH, Hogan WJ. Improved infusion system for intraluminal esophageal manometry. Gastroenterology 1977; 73: 23-7.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.1840040225","article-title":"Frequency of papillary dysfunction among cholecystectomized patients","volume":"4","author":"Bar-Meir, S.; Halpem, Z.; Bardan, E.; Gilat, T.","year":"1984","unstructured":"Bar-Meir S, Halpem Z, Bardan E, Gilat T. Frequency of papillary dysfunction among cholecystectomized patients. Hepatology 1984; 4: 328-30.","journal-title":"Hepatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01307970","article-title":"Endoscopic manometry of pancreatic and biliary sphincter zones in man","volume":"26","author":"Carr-Locke, D.L.; Gregg, J.A.","year":"1981","unstructured":"Carr-Locke DL, Gregg JA. Endoscopic manometry of pancreatic and biliary sphincter zones in man. Dig Dis Sci 1981; 26: 7-15.","journal-title":"Dig Dis Sci"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0016-5085(84)90067-2","article-title":"Bile duct dyskinesia: Clinical and manometric study","volume":"87","author":"Meshkinpour, H.; Mollot, M.; Eckerling, G.B.; Bookman, L.","year":"1984","unstructured":"Meshkinpour H, Mollot M, Eckerling GB, Bookman L. Bile duct dyskinesia: Clinical and manometric study. 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