{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:59:55Z","timestamp":1789750795933,"version":"4.0.1"},"reference-count":10,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1988,11]]},"abstract":"<jats:p>We investigated the distribution of short chain fatty acids (SCFA) in enema samples taken from subjects before sigmoidoscopy as an indicator of possible microbial community differences between subjects subsequently diagnosed as normal or having colonic disorders. The major SCFA in all groups were acetic, propionic, and butyric acids. A significantly higher ratio of acetate to total SCFA and lower ratio of butyrate to total SCFA was found for polyp-colon cancer subjects than for normal subjects. There were no significant differences in the ratios of acetate, propionate, or butyrate between the diverticulosis or inflammatory bowel groups and the normal group. There were no significant sex differences nor were there correlations with the ratios of acetate, propionate or butyrate and age, subject weight, or dry weights of samples. Significant differences in concentrations of individual acids were found between normal and certain diagnostic groups. The difference in proportions of individual SCFA between groups suggest differences in fermentation patterns of the colonic microflora.<\/jats:p>","DOI":"10.1136\/gut.29.11.1539","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1539-1543","source":"Crossref","is-referenced-by-count":113,"title":["Short chain fatty acid distributions of enema samples from a sigmoidoscopy population: an association of high acetate and low butyrate ratios with adenomatous polyps and colon cancer."],"prefix":"10.1136","volume":"29","author":[{"given":"G A","family":"Weaver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T L","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Wolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1988,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/B978-0-12-341280-5.50013-6","article-title":"Carbohydrate fermentation","volume-title":"intestinal microflora in health and disease","author":"Wolin, M.J.; Miller, T.L.","year":"1983","unstructured":"Wolin MJ, Miller TL. Carbohydrate fermentation. In: Hentges DJ, ed. Human intestinal microflora in health and disease. New York: Academic Press, 1983: 147-65."},{"key":"ref_2","article-title":"Constancy of glucose and starch fermentations by two different human fecal microbial communities. Gut. In press. Short chainfatty acid distributions ofenema samplesfrom a sigmoidoscopy population 1543","author":"Weaver, G.A.; Krause, J.A.; Miller, T.L.; Wolin, M.J.","unstructured":"Weaver GA, Krause JA, Miller TL, Wolin MJ. Constancy of glucose and starch fermentations by two different human fecal microbial communities. Gut. In press. Short chainfatty acid distributions ofenema samplesfrom a sigmoidoscopy population 1543"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1084\/jem.133.3.572","article-title":"Factors influencing pulmonary methane excretion in man. 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System Appl Microbiol 1986; 7: 223-9.","journal-title":"System Appl Microbiol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/gut.27.6.698","article-title":"Incidence of methanogenic bacteria in a sigmoidoscopy population: an association of methanogenic bacteria and diverticulosis","volume":"27","author":"Weaver, G.A.; Krause, J.A.; Miller, T.L.; Wolin, M.J.","year":"1986","unstructured":"Weaver GA, Krause JA, Miller TL, Wolin MJ. Incidence of methanogenic bacteria in a sigmoidoscopy population: an association of methanogenic bacteria and diverticulosis. Gut 1986; 27: 698-704.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/AEM.45.1.317-318.1983","article-title":"Stability of Methanobrevibacter smithii populations in the microbial flora excreted from the human large bowel","volume":"45","author":"Miller, T.L.; Wolin, M.J.","year":"1983","unstructured":"Miller TL, Wolin MJ. Stability of Methanobrevibacter smithii populations in the microbial flora excreted from the human large bowel. Appl Environ Microbiol 1983; 45: 317-8.","journal-title":"Appl Environ Microbiol"},{"issue":"19","key":"ref_7","first-page":"89","article-title":"Colonic Absorption: the importance of short chain fatty acids in man","volume":"93","author":"Cummings, J.H.","year":"1984","unstructured":"Cummings, JH. Colonic Absorption: the importance of short chain fatty acids in man. Scand J Gastroenterol 1984; 93 suppl 19: 89-99.","journal-title":"Scand J Gastroenterol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1007\/BF01300193","article-title":"Super-efficient starch absorption. A risk factor for colonic neoplasia","volume":"32","author":"Thornton JR. Dryden A, Kelleher J, Losowsky MS","year":"1987","unstructured":"Thornton JR. Dryden A, Kelleher J, Losowsky MS. Super-efficient starch absorption. A risk factor for colonic neoplasia. Dig Dis Sci 1987; 32: 1088-91.","journal-title":"Dig Dis Sci"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1574-6968.1987.tb02352.x","article-title":"Polysaccharide breakdown by mixed populations of human fecal bacteria","volume":"95","author":"Englyst, H.N.; Hay, S.; McFarlane, G.T.","year":"1987","unstructured":"Englyst HN, Hay S, McFarlane GT. Polysaccharide breakdown by mixed populations of human fecal bacteria. FEMS Microbiol Ecol 1987; 95: 163-71.","journal-title":"FEMS Microbiol Ecol"},{"key":"ref_10","first-page":"65","article-title":"Effects of sodium butyrate, a new pharmacological agent, on cells in culture","volume":"42","author":"Kruh, J.","year":"1982","unstructured":"Kruh J. Effects of sodium butyrate, a new pharmacological agent, on cells in culture. Mol Cell Biochem 1982; 42: 65-82.","journal-title":"Mol Cell Biochem"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.29.11.1539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:27:15Z","timestamp":1765006035000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.29.11.1539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11]]},"references-count":10,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1988,11,1]]},"published-print":{"date-parts":[[1988,11]]}},"alternative-id":["10.1136\/gut.29.11.1539"],"URL":"https:\/\/doi.org\/10.1136\/gut.29.11.1539","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,11]]}}}