{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:44:13Z","timestamp":1765010653148,"version":"3.46.0"},"reference-count":16,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:p>In order to investigate the relationship between oesophageal motor abnormalities and oesophagitis, we carried out four hour studies of oesophageal motility and 24 hour pH measurements in fasting and fed conditions in eight patients before, during (pH only), and after medical healing of erosive oesophagitis. Gastrooesophageal acid reflux decreased (ns) during the treatment, but tended to return to basal values at the end. Oesophageal body motility was unchanged after healing, while the lower oesophageal sphincter basal tone was significantly increased at the end of the study in the postcibal period. The results suggest that the impairment of the sphincter tone in reflux oesophagitis is secondary to the presence of the oesophageal lesions. Macroscopic healing is not paralleled by improved major pathogenic factors of the disease, however--that is, acid reflux and oesophageal body motility.<\/jats:p>","DOI":"10.1136\/gut.29.2.157","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"157-160","source":"Crossref","is-referenced-by-count":37,"title":["Oesophageal function before, during, and after healing of erosive oesophagitis."],"prefix":"10.1136","volume":"29","author":[{"given":"F","family":"Baldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Ferrarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Longanesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Angeloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ragazzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Miglioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Barbara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJM198212163072503","article-title":"Mechanisms of gastroesophageal reflux in patients with reflux esophagitis","volume":"307","author":"Dodds, W.J.; Dent, J.; Hogan, W.J.","year":"1982","unstructured":"Dodds WJ, Dent J, Hogan WJ, et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med 1982; 307: 1547-52.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/gut.25.1.7","article-title":"Motor activity of the distal oesophagus and gastro-oesophageal reflux","volume":"25","year":"1984","unstructured":"Corazziari E, Bontempo 1, Anzini F, Torsoli A. Motor activity of the distal oesophagus and gastro-oesophageal reflux. Gut 1984; 25: 7-13.","journal-title":"Gut"},{"key":"ref_3","first-page":"336","article-title":"Oesophageal motor events at the occurrence of acid reflux and during endogenous acid exposure in healthy subjects and in patients with oesophagitis","volume-title":"Gut","volume":"26","author":"Baldi, F.; Ferrarini, F.; Balestra, R.","year":"1985","unstructured":"Baldi F, Ferrarini F, Balestra R, et al. Oesophageal motor events at the occurrence of acid reflux and during endogenous acid exposure in healthy subjects and in patients with oesophagitis. Gut 1985; 26: 336-41."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0016-5085(19)32647-2","article-title":"Experimental esophagitis impairs lower esophageal sphincter pressure","volume":"69","author":"Eastwood, G.L.; Castell, D.O.; Higgs, R.H.","year":"1975","unstructured":"Eastwood GL, Castell DO, Higgs RH. Experimental esophagitis impairs lower esophageal sphincter pressure. Gastroenterology 1975; 69: 146-53.","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0016-5085(76)80096-0","article-title":"Studies on the mechanism of esophagitis-induced lower esophageal sphincter hypotension in cats","volume":"71","author":"Higgs, R.H.; Castell, D.O.; Eastwood, G.L.","year":"1976","unstructured":"Higgs RH, Castell DO, Eastwood GL. Studies on the mechanism of esophagitis-induced lower esophageal sphincter hypotension in cats. Gastroenterology 1976; 71: 51-7.","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1007\/BF01324902","article-title":"Clinical and manometric findings in benign peptic strictures of the esophagus","volume":"24","author":"Ahtaridis, G.; WJ, jr, Snape; Cohen, S.","year":"1979","unstructured":"Ahtaridis G, Snape WJ jr, Cohen S. Clinical and manometric findings in benign peptic strictures of the esophagus. Dig Dis Sci 1979; 24: 858-61.","journal-title":"Dig Dis Sci"},{"key":"ref_7","first-page":"145","article-title":"Manometric evaluation of the oesophageal peristalsis and of the lower oesophageal sphincter in reflux oesophagitis","volume":"14","author":"Baldi, F.; Ferrarini, F.; Cassan, M.; Balestra, R.; Miglioli, M.; Barbara, L.","year":"1982","unstructured":"Baldi F, Ferrarini F, Cassan M, Balestra R, Miglioli M, Barbara L. Manometric evaluation of the oesophageal peristalsis and of the lower oesophageal sphincter in reflux oesophagitis. ItalJ Gastroenterol 1982; 14: 145-9.","journal-title":"ItalJ Gastroenterol"},{"key":"ref_8","first-page":"290","article-title":"Does surgery correct esophageal motor dysfunction in gastroesophageal reflux'?","author":"Russell, C.O.H.; Pope CE, II, Gannan; RM, Allen; FD, Velasco; N, Hill; L.D.","year":"1981","unstructured":"Russell COH, Pope CE II, Gannan RM, Allen FD, Velasco N, Hill LD. Does surgery correct esophageal motor dysfunction in gastroesophageal reflux'? Ann Surg 1981;194:290-6.","journal-title":"Ann Surg"},{"key":"ref_9","first-page":"297","article-title":"When is esophagitis healed? Esophageal endoscopy, histology and function before and after cimetidine treatment","volume":"27","author":"Sonnenberg, A.; Lepsien, G.; Mueller-Lissner, S.A.; Koelz, H.R.; Siewert, R.; Blum, A.L.","year":"1982","unstructured":"Sonnenberg A, Lepsien G, Mueller-Lissner SA, Koelz HR, Siewert R, Blum AL. When is esophagitis healed? Esophageal endoscopy, histology and function before and after cimetidine treatment. Dig Dis Sci 1982; 27: 297-302.","journal-title":"Dig Dis Sci"},{"key":"ref_10","article-title":"The esophagus. Handbook and atlas of endoscopy","author":"Savary, M.; Miller, G.","year":"1977","unstructured":"Savary M, Miller G. The esophagus. Handbook and atlas of endoscopy. 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