{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:35:55Z","timestamp":1770964555330,"version":"3.50.1"},"reference-count":26,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1988,3]]},"abstract":"<jats:p>In order to identify the risk factors affecting the healing of duodenal ulcer, a clinical trial with effective dose of antacid was carried out in 53 patients. Duration of ulcer history, number of relapses, duration of the last and present relapse, number, duration and severity of pain attacks in the present ulcer relapse, pain radiation to back, vomiting, appetite, smoking habit, intake of analgesics and previous haemorrhage were registered. Number of ulcers, ulcer depth, bublar narrowing, erosions, duodenitis at initial endoscopy and healing of ulcer were assessed by one endoscopist. Basic and peak acid output were measured. The extent of duodenitis on the site opposite the ulcer was determined by histological examination. Sixty per cent of the duodenal ulcers were healed after three weeks. By univariate analysis, the following factors affect the healing; pain radiation to back and pain duration during treatment (p less than 0.001), multiple or deep ulcers, narrowing of duodenal bulb (p less than 0.01), number of pain attacks and poor appetite (p less than 0.05). By the stepwise logistic regression model, the following factors were selected as predictors for healing of duodenal ulcer with 76% correct classification: pain radiation to back (p = 0.002), deep ulcer (p = 0.013), multiple ulcers (p = 0.028). Number of cigarettes\/day (p less than 0.007) and male sex (p = 0.036). By this model, the prediction of healing could be accurately assessed in 78% in a new sample. Individual treatment should be carried out on the basis of these factors.<\/jats:p>","DOI":"10.1136\/gut.29.3.291","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"291-297","source":"Crossref","is-referenced-by-count":8,"title":["Risk factors for healing of duodenal ulcer under antacid treatment: do ulcer patients need individual treatment?"],"prefix":"10.1136","volume":"29","author":[{"given":"S","family":"Massarrat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H G","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Schmitz-Moormann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,3,1]]},"reference":[{"key":"ref_1","first-page":"341","volume":"297","author":"En, N.; gl J Med","year":"1977","unstructured":"N En,gl J Med 1977; 297: 341-5."},{"key":"ref_2","first-page":"1195","article-title":"Prediction of a possibility of healing","volume-title":"duodenal ulcer [Abstracti. Gastroenterology 1979; 76","author":"Massairrat, S.; Eisenmann, A.; Janzen, R.; Holle, R.","unstructured":"Massairrat S, Eisenmann A, Janzen R, Holle R. Prediction of a possibility of healing duodenal ulcer [Abstracti. Gastroenterology 1979; 76: 1195."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/gut.22.2.97","article-title":"Factors affecting the healing rate of duodenal and pyloric ulcers with low-dose antacid treatment","volume":"22","author":"Massarrat, S.; Eisenmann, A.","year":"1981","unstructured":"Massarrat S, Eisenmann A. Factors affecting the healing rate of duodenal and pyloric ulcers with low-dose antacid treatment. Gut 1981; 22: 97-102.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00004836-198208000-00004","article-title":"Cimetidine and duodenal ulcer: an analysis of methodologic problems in randomized controlled trials","volume":"4","author":"Chuong, J.J.H.; Spiro, H.M.","year":"1982","unstructured":"Chuong JJH, Spiro HM. Cimetidine and duodenal ulcer: an analysis of methodologic problems in randomized controlled trials. J Clin Gastroenterol 1982; 4: 311-20.","journal-title":"J Clin Gastroenterol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0016-5085(79)90339-1","article-title":"Treatment of duodenal ulcer with antacid and sulpiride","volume":"76","author":"Lam, S.K.; Lam, K.C.; Lai, C.L.; Yeung, C.K.; Yam, L.Y.C.; Wong, W.S.","year":"1979","unstructured":"Lam SK, Lam KC, Lai CL, Yeung CK, Yam LYC, Wong WS. Treatment of duodenal ulcer with antacid and sulpiride. Gastroenterology 1979; 76: 315-22.","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0016-5085(81)80012-1","article-title":"Prediction of duodenal ulcer healing and relapse","volume":"81","author":"Sonnenberg, A.; Miiller-Lissner, S.A.; Vogel, E.","year":"1981","unstructured":"Sonnenberg A, Miiller-Lissner SA, Vogel E. Prediction of duodenal ulcer healing and relapse. Gastroenterology 1981;81: 1061-7.","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/0016-5085(81)90256-0","article-title":"Influence of smoking on healing rate of duodenal ulcer in response to cimetidine or high-dose antacid","volume":"80","author":"Korman, M.G.; Shaw, R.G.; Hansky, J.; Schmidt, G.T.; Al, Stern","year":"1981","unstructured":"Korman MG, Shaw RG, Hansky J, Schmidt GT, Stern Al. Influence of smoking on healing rate of duodenal ulcer in response to cimetidine or high-dose antacid. Gastroenterology 1981; 80: 1451-3.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"1152","article-title":"Factors predicting the treatment outcome of duodenal ulcer treatment with H,-receptor antagonists","volume":"63","author":"Gugler, R.; Jensen, J.C.; Rohner, H.G.; Reimnitz, P.; Somogyi, A.","year":"1982","unstructured":"Gugler R, Jensen JC, Rohner HG, Reimnitz P, Somogyi A. Factors predicting the treatment outcome of duodenal ulcer treatment with H,-receptor antagonists. Klin. Wochenschr 1982; 63: 1152-9.","journal-title":"Klin. Wochenschr"},{"issue":"866-71","key":"ref_9","first-page":"1","article-title":"Effect of smoking on duodenal ulcer healing with cimetidine and oxmetidine","volume":"23","author":"Gugler, R.; Rohner, H.G.; Kratochvil, P.; Brandstaetter, G.","year":"1982","unstructured":"Gugler R, Rohner HG, Kratochvil P, Brandstaetter G. \"Effect of smoking on duodenal ulcer healing with cimetidine and oxmetidine\". Cut 1982; 23: 866-71. 1() van Deventer GM, Schneidman D, Walsh JH. Sucralfate and cimetidine as single agents and in combination for treatment of active duodenal ulcers. A double blind, placebo-controlled trial. Am J Med 1985; 79: suppl 2c: 39-44.","journal-title":"Cut; Sucralfate and cimetidine as single agents and in combination for treatment of active duodenal ulcers. A double blind, placebo-controlled trial"},{"issue":"15","key":"ref_10","first-page":"65","article-title":"Trimipramine in the treatment of duodenal ulcer. A. multicenter open study","volume":"1980","author":"Valnes, K.; Wetterhus, S.; Ellekjaer, E.","unstructured":"Valnes K, Wetterhus S, Ellekjaer E. Trimipramine in the treatment of duodenal ulcer. A. multicenter open study. ScandJ Gastroetiterol 1980; 15: suppl 58: 65-70.","journal-title":"ScandJ Gastroetiterol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/gut.25.7.711","article-title":"Refractory duodenal ulcer","volume":"25","author":"Bardhan, K.D.","year":"1984","unstructured":"Bardhan KD. Refractory duodenal ulcer. Gut 1984; 25: 711-17.","journal-title":"Gut"},{"key":"ref_12","first-page":"85","article-title":"Cigarette smoking and duodenal ulcer healing, an endoscopic study","volume":"29","author":"Barakat, M.W.; Menon, K.N.; Badawi, A.R.","year":"1984","unstructured":"Barakat MW, Menon KN, Badawi AR. Cigarette smoking and duodenal ulcer healing, an endoscopic study of 197 patients. Digestion 1984; 29: 85-90."},{"key":"ref_13","first-page":"71","article-title":"Hat die Form des Ulcus duodeni prognostische Bedeutung bei der Cimetidin-therapie? Bericht fiber die Resultate einer Schweizer Multizenterstudie","volume":"26","author":"Blum, A.L.","year":"1982","unstructured":"Blum AL. Hat die Form des Ulcus duodeni prognostische Bedeutung bei der Cimetidin-therapie? Bericht fiber die Resultate einer Schweizer Multizenterstudie. Z Gastroenterol 1982; 26: 71-3.","journal-title":"Z Gastroenterol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0016-5085(82)90048-8","article-title":"Gastric acid secretion, smoke and duodenal ulcer healing","volume":"82","author":"G, Bianchi Porro; A, Prada; M, Petrillo; M, Lazzaroni","year":"1982","unstructured":"Bianchi Porro G, Prada A, Petrillo M, Lazzaroni M. Gastric acid secretion, smoke and duodenal ulcer healing. [Correspondencel. Gastroenterology 1982; 82: 394-5.","journal-title":"[Correspondencel. Gastroenterology"},{"key":"ref_15","first-page":"17","article-title":"Antro-duodenitis in duodenal ulcers and non-ulcer dyspepsia","volume-title":"duodenal ulcer","author":"Whitehead, R.; Roca, M.; Truelove, S.C.","year":"1974","unstructured":"Whitehead R, Roca M, Truelove SC. Antro-duodenitis in duodenal ulcers and non-ulcer dyspepsia. In: Wastell C, ed. Chronic duodenal ulcer. London: Butterworths, 1974: 17-23."},{"key":"ref_16","article-title":"BMDP - Biomedical computer programs","author":"Dixon, W.J.","year":"1985","unstructured":"Dixon WJ. (ed) BMDP - Biomedical computer programs. Los Angeles: University of California Press, 1985."},{"issue":"30","key":"ref_17","first-page":"45","article-title":"Factors influencing healing of duodenal ulcer. Control of nocturnal secretion by H2 blockade and characteristics of patients who failed to heal","volume":"1985","author":"Lam, S.K.; Lai, C.L.; Lee, L.N.W.; Fok, K.H.; Ng, M.M.T.; Siu, K.F.","unstructured":"Lam SK, Lai CL, Lee LNW, Fok KH, Ng MMT, Siu KF. Factors influencing healing of duodenal ulcer. Control of nocturnal secretion by H2 blockade and characteristics of patients who failed to heal. Dig Dis Sci 1985:30: 45-51.","journal-title":"Dig Dis Sci"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1136\/bmj.282.6267.866","article-title":"Women and duodenal ulcer","volume":"282","author":"Peden, N.R.; Boyd, E.J.S.; Wormsley, K.G.","year":"1981","unstructured":"Peden NR, Boyd EJS, Wormsley KG. Women and duodenal ulcer. Br Med J 1981; 282: 866.","journal-title":"Br Med J"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0016-5085(83)90330-X","article-title":"Accurate prediction of duodenal ulcer healing rate by discriminant analysis","volume":"85","author":"Lam, S.K.; Koo, J.","year":"1983","unstructured":"Lam SK, Koo J. Accurate prediction of duodenal ulcer healing rate by discriminant analysis. Gastroenterology 1983; 85: 403-12.","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/00365528609090935","article-title":"et al Rate of duodenal ulcer healing during treatment with omeprazole. A double-blind comparison of a daily dose of 30 mg versus 60 mg","volume":"21","author":"Ch, Dive; R, Fiasse; S, Thome","year":"1986","unstructured":"Dive Ch, Fiasse R, Thome S, et al Rate of duodenal ulcer healing during treatment with omeprazole. A double-blind comparison of a daily dose of 30 mg versus 60 mg. Scand J Gastroenterol 1986; 21: suppl: 175-6.","journal-title":"Scand J Gastroenterol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1055\/s-0028-1098189","article-title":"Endoscopie follow-up observation of duodenal ulcer","volume":"4","author":"Kohli, Y.; Misaki, F.; Kawai, K.","year":"1972","unstructured":"Kohli Y, Misaki F, Kawai K. Endoscopie follow-up observation of duodenal ulcer. Endoscopy 1972; 4: 202-8.","journal-title":"Endoscopy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/00365528509089643","article-title":"Comparison of ranitidine and high-dose antacid in the treatment of prepyloric of duodenal ulcer","volume":"20","author":"Lauritsen, K.; Bytzer, P.; Hansen, J.; Becker, C.","year":"1985","unstructured":"Lauritsen K, Bytzer P, Hansen J, Becker C. Comparison of ranitidine and high-dose antacid in the treatment of prepyloric of duodenal ulcer. Scand J Gastroenterol 1985; 20: 123-8.","journal-title":"Scand J Gastroenterol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1136\/gut.25.10.1113","article-title":"Treatment of cimetidine-resistant chronic duodenal ulcers with ranitidine or cimetidine for eight weeks","volume":"25","author":"Quatrini, M.; Basilico, G.; Bianchi, P.A.","year":"1984","unstructured":"Quatrini M, Basilico G, Bianchi PA. Treatment of cimetidine-resistant chronic duodenal ulcers with ranitidine or cimetidine for eight weeks. Gut 1984; 25: 1113-7.","journal-title":"Gut"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1136\/gut.26.12.1327","article-title":"Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients","volume":"26","year":"1985","unstructured":"Parente F, Lazzaroni M, Sangaletti 0, Baroni S, Bianchi Porro G. Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients. Gut 1985; 26: 1327-32.","journal-title":"Gut"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/gut.27.4.433","article-title":"Increased gastric secretory capacity in smokers without gastrointestinal lesions","volume":"27","author":"Massarrat, S.; Enschai, F.; Pittner, P.M.","year":"1986","unstructured":"Massarrat S, Enschai F, Pittner PM. Increased gastric secretory capacity in smokers without gastrointestinal lesions. Gut 1986; 27: 433-9.","journal-title":"Gut"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3109\/00365528608996421","article-title":"Treatment of duodenal ulcer with low-dose antacids","volume":"21","author":"Lux, G.; Hentschel, H.; Rohner, H.G.","year":"1986","unstructured":"Lux G, Hentschel H, Rohner HG, et al. Treatment of duodenal ulcer with low-dose antacids. Scand J Gastroenterol 1986; 21: 1063-8.","journal-title":"Scand J Gastroenterol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.29.3.291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:29:46Z","timestamp":1765607386000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.29.3.291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1988,3,1]]},"published-print":{"date-parts":[[1988,3]]}},"alternative-id":["10.1136\/gut.29.3.291"],"URL":"https:\/\/doi.org\/10.1136\/gut.29.3.291","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3]]}}}