{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:45:11Z","timestamp":1765647911513,"version":"3.48.0"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:p>The association of hyperglobulinaemia with renal tubular acidosis and nephrogenic diabetes insipidus is well established. A patient with marked hyperglobulinaemia due to autoimmune chronic active hepatitis is described who presented with severe polydipsia and polyuria but had entirely normal renal tubular function indicating a primary thirst disorder.<\/jats:p>","DOI":"10.1136\/gut.29.4.548","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"548-549","source":"Crossref","is-referenced-by-count":1,"title":["Non-psychogenic primary polydipsia in autoimmune chronic active hepatitis with severe hyperglobulinaemia."],"prefix":"10.1136","volume":"29","author":[{"given":"M V","family":"Tobin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A I","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,4,1]]},"reference":[{"key":"ref_1","unstructured":"Renal acidification and concentrating capacity are defective and the sensation of thirst is appropriate to induced changes in plasma osmolality and volume. Primary polydipsia, however, is a disorder of thirst in which an urge to drink persists in the absence of known physiological thirst stimuli.3 It is usually seen in association with cerebral damage4 and rarely in hypercalcaemia,' severe potassium depletion5 and hyper-reninaemia.46' It has also been reported in thyrotoxicosis8 and in hypothalamic - pituitary sarcoidosis with normal ADH function.9 Psychogenic","article-title":"Renal acidification and concentrating capacity are defective and the sensation of thirst is appropriate to induced changes in plasma osmolality and volume. Primary polydipsia, however, is a disorder of thirst in which an urge to drink persists in the absence of known physiological thirst stimuli.3 It is usually seen in association with cerebral damage4 and rarely in hypercalcaemia,' severe potassium depletion5 and hyper-reninaemia.46' It has also been reported in thyrotoxicosis8 and in hypothalamic - pituitary sarcoidosis with normal ADH function.9 Psychogenic"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/bmj.3.5715.143","article-title":"Hyperglobulinaemic renal tubular acidosis: a report of nine cases","volume":"iii:","author":"Mason, A.M.S.; Golding, P.L.","year":"1970","unstructured":"Mason AMS, Golding PL. Hyperglobulinaemic renal tubular acidosis: a report of nine cases. Br Med J 1970; iii: 143-6.","journal-title":"Br Med J"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.7326\/0003-4819-67-1-110","article-title":"Hyperglobulinemic renal tubular acidosis","volume":"67","author":"McCurdy, D.K.; Cornwell, G.G.; DePratti, V.J.","year":"1967","unstructured":"McCurdy DK, Cornwell GG, DePratti VJ. Hyperglobulinemic renal tubular acidosis. Ann Intern Med 1967;67: 110-7.","journal-title":"Ann Intern Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.me.33.020182.001311","volume":"33","author":"Andersson, B.; Rundgren, M.","year":"1982","unstructured":"Andersson B, Rundgren M. Thirst and its disorders. Ann Rev Med 1982; 33: 231-9.","journal-title":"Thirst and its disorders. Ann Rev Med"},{"key":"ref_5","article-title":"The physiology of thirst and sodium appetite","volume":"35","author":"Fitzsimons, J.T.","unstructured":"Fitzsimons JT. The physiology of thirst and sodium appetite. Monogr Physiol Soc 1979, no. 35.","journal-title":"Monogr Physiol Soc 1979"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0140-6736(59)90198-9","article-title":"Thirst and polyuria with a note on the effects of potassium deficiency and calcium excess","volume":"i:","author":"Fourman, P.; Leeson, P.M.","year":"1959","unstructured":"Fourman P, Leeson PM. Thirst and polyuria with a note on the effects of potassium deficiency and calcium excess. Lancet 1959; i: 268-71.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1001\/jama.1973.03220380048013","article-title":"Renal failure, uncontrollable thirst and hyperreninemia. Cessation of thirst with bilateral nephrectomy","volume":"225","author":"Rogers, P.W.; Kurtzman, N.A.","year":"1973","unstructured":"Rogers PW, Kurtzman NA. Renal failure, uncontrollable thirst and hyperreninemia. Cessation of thirst with bilateral nephrectomy. JAMA 1973; 225: 1236-8.","journal-title":"JAMA"},{"key":"ref_8","first-page":"921","article-title":"Polydipsia, polyuria and hypertension associated with reninsecreting Wilms'","volume":"92","author":"Sheth, K.J.; Tang, T.T.; Blaedel, M.E.; Good, T.A.","year":"1978","unstructured":"Sheth KJ, Tang TT, Blaedel ME, Good TA. Polydipsia, polyuria and hypertension associated with reninsecreting Wilms' tumour. J Pediatr 1978; 92: 921-4.","journal-title":"tumour. J Pediatr"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0026-0495(72)90052-2","article-title":"Primary polydipsia in thyrotoxicosis","volume":"21","author":"Evered, D.C.; Hayter, C.J.; Surveyor, I.","year":"1972","unstructured":"Evered DC, Hayter CJ, Surveyor I. Primary polydipsia in thyrotoxicosis. Metabolism 1972; 21: 393-403.","journal-title":"Metabolism"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1056\/NEJM198011063031902","article-title":"Disordered control of thirst in hypothalamic-pituitary sarcoidosis","volume":"303","author":"Stuart, C.A.; Neelon, F.A.; Lebovitz, H.E.","year":"1980","unstructured":"Stuart CA, Neelon FA, Lebovitz HE. Disordered control of thirst in hypothalamic-pituitary sarcoidosis. N Engl J Med 1980; 303: 1078-82.","journal-title":"N Engl J Med"},{"key":"ref_11","first-page":"235","article-title":"Compulsive water drinking","volume":"28","author":"Barlow, E.D.; DeWardener, H.E.","year":"1959","unstructured":"Barlow ED, DeWardener HE. Compulsive water drinking. Q J Med 1959; 28: 235-58.","journal-title":"Q J Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.29.4.548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:41:34Z","timestamp":1765647694000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.29.4.548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1988,4,1]]},"published-print":{"date-parts":[[1988,4]]}},"alternative-id":["10.1136\/gut.29.4.548"],"URL":"https:\/\/doi.org\/10.1136\/gut.29.4.548","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1988,4]]}}}