{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:14:41Z","timestamp":1772756081016,"version":"3.50.1"},"reference-count":26,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:p>Combined treatment with cimetidine 1 g daily and cisapride 40 mg daily in patients with endoscopically diagnosed severe reflux oesophagitis was compared with single drug therapy (cimetidine and placebo). At the end of the six to 12 weeks treatment, 11 (46%) of the 24 patients under single drug therapy were endoscopically healed and three were improved. In contrast, 16 (70%) of the 23 patients under combined therapy were healed and all of the remainder were improved (p = 0.025). The severity of diurnal and nocturnal heartburn, decreased significantly more (p less than 0.05) on cimetidine + cisapride than on cimetidine + placebo. The combined treatment was well tolerated. These results suggest that combined therapy with cisapride and cimetidine may be useful in patients with severe reflux oesophagitis.<\/jats:p>","DOI":"10.1136\/gut.29.5.675","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"675-681","source":"Crossref","is-referenced-by-count":67,"title":["Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial."],"prefix":"10.1136","volume":"29","author":[{"given":"J P","family":"Galmiche","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Brandst\u00e4tter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Evreux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Hentschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kerstan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Kratochvil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Reichel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Sch\u00fctze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Soule","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Vitaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00000658-197610000-00009","article-title":"Patterns of gastroesophageal reflux in health and disease","volume":"184","author":"TR, De Meester; LF, Johnson; GJ, Joseph; MS, Toscano; AX, Hall; DB, Skinner","year":"1976","unstructured":"De Meester TR, Johnson LF, Joseph GJ, Toscano MS, Hall AX, Skinner DB. Patterns of gastroesophageal reflux in health and disease. Ann Surg 1976; 184: 459-70.","journal-title":"Ann Surg"},{"key":"ref_2","first-page":"376","volume-title":"Pathogenesis of reflux oesophagitis. Gastroenterology 1981; 81","author":"Dodds, W.J.; Hogan, W.J.; Helm, J.F.; Dent, J.","unstructured":"Dodds WJ, Hogan WJ, Helm JF, Dent J. Pathogenesis of reflux oesophagitis. Gastroenterology 1981; 81: 376-94."},{"key":"ref_3","first-page":"3","article-title":"Introduction to pathophysiology of gastroesophageal reflux","volume-title":"reflux disease","author":"Castell, D.O.","year":"1985","unstructured":"Castell DO. Introduction to pathophysiology of gastroesophageal reflux. In: Castell DO, Wu WC, Ott DJ, eds. Gastroesophageal reflux disease. New York: Futura, 1985: 3-9."},{"key":"ref_4","first-page":"221","article-title":"Gastroesophageal reflux disease: a review of medical therapy","volume-title":"reflux disease","author":"Richter, J.E.","year":"1985","unstructured":"Richter JE. Gastroesophageal reflux disease: a review of medical therapy. In: Castell DO, Wu WC, Ott DJ, eds. Gastroesophageal reflux disease. New York: Futura, 1985: 221-41."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7326\/0003-4819-104-1-112","article-title":"Medical therapy for reflux esophagitis: 1986 and beyond","volume":"104","author":"Castell, D.O.","year":"1986","unstructured":"Castell DO. Medical therapy for reflux esophagitis: 1986 and beyond. Ann Intern Med 1986; 104: 112-4.","journal-title":"Ann Intern Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ddr.430080130","article-title":"Development and clinical use of the new gastrointestinal prokinetic drug cisapride","volume":"8","author":"Reyntjens, A.; Verlinden, M.; Aerts, T.","year":"1986","unstructured":"Reyntjens A, Verlinden M, Aerts T. Development and clinical use of the new gastrointestinal prokinetic drug cisapride (R 51 619). Drug Dev Res 1986; 8: 251-65.","journal-title":"Drug Dev Res"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/gut.26.4.352","article-title":"Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride)","volume":"26","author":"Jian, R.; Ducrot, F.; Piedeloup, C.; Mary, J.Y.; Najean, Y.; Bernier, J.J.","year":"1985","unstructured":"Jian R, Ducrot F, Piedeloup C, Mary JY, Najean Y, Bernier JJ. Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride). Gut 1985; 26: 352-8.","journal-title":"Gut"},{"key":"ref_8","first-page":"354","article-title":"Chronic oral treatment with cisapride decreases high bile salt reflux rates","volume":"81","author":"Muller-Lissner, S.A.; Fraass, C.","year":"1986","unstructured":"Muller-Lissner SA, Fraass C. Chronic oral treatment with cisapride decreases high bile salt reflux rates. Am J Gastroenterol 1986; 81: 354-7.","journal-title":"Am J Gastroenterol"},{"key":"ref_9","first-page":"1045","article-title":"Clinical pharmacological evidence for cisapride's lack of antidopaminergic or direct cholinergic properties","volume":"36","author":"Reyntjens, A.; Verlinden, M.; De Coster, R.","year":"1984","unstructured":"Reyntjens A, Verlinden M, De Coster R, et al. Clinical pharmacological evidence for cisapride's lack of antidopaminergic or direct cholinergic properties. Curr Ther Res 1984; 36: 1045-52.","journal-title":"Curr Ther Res"},{"key":"ref_10","article-title":"Controlled study of cisapride in the treatment of grade","volume-title":"II and III oesophagitis [Abstract]. Gastroenterology 1987; 92","author":"Lepoutre, L.; Vanderlinden, I.; Bollen, G.","year":"1501","unstructured":"Lepoutre L, Vanderlinden I, Bollen G, et al. Controlled study of cisapride in the treatment of grade II and III oesophagitis [Abstract]. Gastroenterology 1987; 92: 1501."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.7326\/0003-4819-104-1-21","article-title":"Treatment of severe reflux esophagitis with cimetidine and metoclopramide","volume":"104","author":"Liebermann, D.A.; Keeffe, E.B.","year":"1986","unstructured":"Liebermann DA, Keeffe EB. Treatment of severe reflux esophagitis with cimetidine and metoclopramide. Ann Intern Med 1986; 104: 21-6.","journal-title":"Ann Intern Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1136\/bmj.286.6381.1863","article-title":"Cimetidine and metoclopramide in oesophageal reflux disease","volume":"286","author":"Temple, J.G.; Bradby, G.V.; O'Connor, F.","year":"1983","unstructured":"Temple JG, Bradby GV, O'Connor F, et al. Cimetidine and metoclopramide in oesophageal reflux disease. Br Med J 1983; 286: 1863-4. Cisaprideplus cimetidine in oesophagitis","journal-title":"Br Med J"},{"key":"ref_13","article-title":"Manuel et atlas d'endoscopie","author":"Savary, M.; L'oesophage, Miller G.","year":"1977","unstructured":"Savary M, Miller G. L'oesophage. Manuel et atlas d'endoscopie. Solothurn, Switzerland: Gassmann AG, 1977."},{"key":"ref_14","first-page":"312","article-title":"Nonparametric statistics","author":"Siegel, S.","year":"1956","unstructured":"Siegel S. Nonparametric statistics. New York: McGrawHill, 1956: 312."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2307\/2527727","article-title":"How to use ridit analysis","volume":"14","author":"Bross, I.D.J.","year":"1958","unstructured":"Bross IDJ. How to use ridit analysis. Biometrics 1958; 14:18-38.","journal-title":"Biometrics"},{"key":"ref_16","first-page":"321","article-title":"Biometry","author":"Sokal, R.R.; Rohlf, F.J.","unstructured":"Sokal RR, Rohlf FJ. Biometry. San Francisco: W H Freeman, 1981: 321"},{"key":"ref_17","article-title":"User's Guide: Statistics","author":"SAS","unstructured":"SAS. User's Guide: Statistics. Cary, NC: SAS Institute Inc, 1985: 956."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0016-5085(78)90778-3","article-title":"Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double-blind controlled trial","volume":"74","author":"Behar, J.; Brand, D.L.; Brown, F.C.","year":"1978","unstructured":"Behar J, Brand DL, Brown FC, et al. Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double-blind controlled trial. Gastroenterology 1978; 74: 441-8.","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/BF01345293","article-title":"Controlled trial of cimetidine in reflux esophagitis","volume":"25","author":"Fiasse, R.; Hanin, C.; Lepot, A.; Deschamps, C.; Lamy, F.; Dive, C.","year":"1980","unstructured":"Fiasse R, Hanin C, Lepot A, Deschamps C, Lamy F, Dive C. Controlled trial of cimetidine in reflux esophagitis. Dig Dis Sci 1980; 25: 750-5.","journal-title":"Dig Dis Sci"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0016-5085(78)90133-6","article-title":"Oral cimetidine in reflux esophagitis: a doubleblind controlled trial","volume":"74","author":"Wesdorp, E.; Bartelsman, J.; Pape, K.; Dekker, W.; Tijtgat, G.N.","year":"1978","unstructured":"Wesdorp E, Bartelsman J, Pape K, Dekker W, Tijtgat GN. Oral cimetidine in reflux esophagitis: a doubleblind controlled trial. Gastroenterology 1978; 74: 821-4.","journal-title":"Gastroenterology"},{"key":"ref_21","first-page":"921","article-title":"Treatment of reflux oesophagitis with ranitidine","volume-title":"Gut","volume":"24","author":"Wesdorp, I.C.E.; Dekker, W.; Klinkenberg-Knol, E.C.","year":"1983","unstructured":"Wesdorp ICE, Dekker W, Klinkenberg-Knol EC. Treatment of reflux oesophagitis with ranitidine. Gut 1983; 24: 921-4."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1056\/NEJM197702172960702","article-title":"A controlled trial of metoclopramide in symptomatic gastroesophageal reflux","volume":"296","author":"McCallum, R.W.; Ippoliti, A.F.; Cooney, C.; Sturdevant, R.A.L.","year":"1977","unstructured":"McCallum RW, Ippoliti AF, Cooney C, Sturdevant RAL. A controlled trial of metoclopramide in symptomatic gastroesophageal reflux. N Engl J Med 1977; 296: 354-7.","journal-title":"N Engl J Med"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"805","DOI":"10.7326\/0003-4819-93-6-805","article-title":"Reflux esophagitis: effect of oral bethanechol on symptoms and endoscopic findings","volume":"93","author":"Thanik, K.D.; Chey, W.Y.; Shah, A.S.; Guttierez, J.G.","year":"1980","unstructured":"Thanik KD, Chey WY, Shah AS, Guttierez JG. Reflux esophagitis: effect of oral bethanechol on symptoms and endoscopic findings. Ann Intern Med 1980; 93: 805-8.","journal-title":"Ann Intern Med"},{"key":"ref_24","article-title":"A double-blind multicenter trial to compare the efficacy of cisapride (CIS) and ranitidine (RAN) in the acute treatment of gastroesophageal reflux","volume-title":"disease (GERD) [Abstract]. Gastroenterology 1986; 90: 1475","author":"Janisch, H.D.","unstructured":"Janisch HD. A double-blind multicenter trial to compare the efficacy of cisapride (CIS) and ranitidine (RAN) in the acute treatment of gastroesophageal reflux disease (GERD) [Abstract]. Gastroenterology 1986; 90: 1475."},{"issue":"31","key":"ref_25","first-page":"217","article-title":"Therapeutic effect of cisapride added on to ranitidine in patients with reflux esophagitis","volume":"1986","author":"Wienbeck, M.","year":"1984","unstructured":"Wienbeck M. Therapeutic effect of cisapride added on to ranitidine in patients with reflux esophagitis [Abstract]. Dig Dis Sci 1986; 31: suppl: 27S. 26 Desechalliers JP, Galmiche JP, Touchais JY, Denis P, Colin R. Ranitidine, cimetidine, antacids and gastro-oesophageal reflux: Results of a 20-hour oesophageal pH study. Int J Clin Pharmacol Res 1984; 4: 217-22.","journal-title":"Dig Dis Sci; antacids and gastro-oesophageal reflux: Results of a 20-hour oesophageal pH study"},{"issue":"31","key":"ref_26","article-title":"Effect of cisapride on gastrooesophageal reflux in children with chronic bronchopulmonary disease (CBPD). A pH-metric study","volume":"1986","author":"Forget, P.P.; Saye, P.","unstructured":"Forget PP, Saye P. Effect of cisapride on gastrooesophageal reflux in children with chronic bronchopulmonary disease (CBPD). A pH-metric study [Abstract]. Dig Dis Sci 1986; 31: suppl: 28S.","journal-title":"Dig Dis Sci"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.29.5.675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:47:22Z","timestamp":1765604842000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.29.5.675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1988,5,1]]},"published-print":{"date-parts":[[1988,5]]}},"alternative-id":["10.1136\/gut.29.5.675"],"URL":"https:\/\/doi.org\/10.1136\/gut.29.5.675","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}