{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:53:03Z","timestamp":1792810383736,"version":"4.5.0"},"reference-count":27,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:p>Gastrointestinal (GI) pH has been measured in 66 normal subjects using a pH sensitive radiotelemetry capsule passing freely through the gastrointestinal tract. Signals were recorded with a portable solid state receiver and recording system, enabling unconstrained measurements with normal ambulatory activities for up to 48 h during normal GI transit. Capsule position in the gut was monitored by surface location using a directional detector. Gastric pH was highly acidic (range 1.0-2.5) in all subjects. The mean pH in the proximal small intestine was 6.6 (0.5) for the first hour of intestinal recording. By comparison the mean pH in the terminal ileum was 7.5 (0.4) (p less than 0.001). In all subjects there was a sharp fall in pH to a mean of 6.4 (0.4) (p less than 0.001) as the capsule passed into the caecum. Values are means (SD). pH then rose progressively from the right to the left colon with a final mean value of 7.0 (0.7) (p less than 0.001).<\/jats:p>","DOI":"10.1136\/gut.29.8.1035","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1035-1041","source":"Crossref","is-referenced-by-count":1100,"title":["Measurement of gastrointestinal pH profiles in normal ambulant human subjects."],"prefix":"10.1136","volume":"29","author":[{"given":"D F","family":"Evans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Pye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bramley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A G","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T J","family":"Dyson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J D","family":"Hardcastle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1988,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000199298","article-title":"24 hour intragastric pH: Continuous monitoring or nasogastric aspiration?","volume":"33","author":"Reynolds, JR, Walt; RP, Hardcastle; JD, Clark; AG, Smart; HL, Langman; M.","year":"1986","unstructured":"Reynolds JR, Walt RP, Hardcastle JD, Clark AG, Smart HL, Langman M. 24 hour intragastric pH: Continuous monitoring or nasogastric aspiration? 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Oxford: Pergammon Press, 1979: 209-12."},{"key":"ref_6","first-page":"213","article-title":"An accurate, long term pH sensitive radiopill for ingestion and implantation","volume":"4","author":"Colson, R.H.; Watson, B.W.; Fairclough, P.D.","year":"1981","unstructured":"Colson RH, Watson BW, Fairclough PD, et al. An accurate, long term pH sensitive radiopill for ingestion and implantation. Biotelemetry Patient Monitg 1981; 4: 213-27.","journal-title":"Biotelemetry Patient Monitg"},{"key":"ref_7","first-page":"4","article-title":"Ambulatory monitoring of gastrointestinal pH in man using a radiotelemetry capsule and a new solid state recorder","volume":"74","author":"Evans, D.F.; Jones, J.A.; Hardcastle, J.D.","year":"1985","unstructured":"Evans DF, Jones JA, Hardcastle JD. Ambulatory monitoring of gastrointestinal pH in man using a radiotelemetry capsule and a new solid state recorder. 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Gut 1982; 23: 992-8.","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0141-5425(82)90010-3","article-title":"A portable radiotelemetry receiver for ambulatory monitoring","volume":"4","author":"Slater, E.J.; Evans, D.F.; Hardcastle, J.D.","year":"1982","unstructured":"Slater EJ, Evans DF, Hardcastle JD. A portable radiotelemetry receiver for ambulatory monitoring. J Biomed Eng 1982; 4: 247-51.","journal-title":"J Biomed Eng"},{"key":"ref_14","first-page":"292","article-title":"Circuit for searching for a signal from a three aerial system during inductive loop telemetry","volume":"8","author":"Jacob, R.; Riddle, H.; Watson, B.W.","year":"1973","unstructured":"Jacob R, Riddle H, Watson BW. Circuit for searching for a signal from a three aerial system during inductive loop telemetry. 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Lancet 1981; i: 1081-2.","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1969.1","article-title":"The geographical distribution of cancer","volume":"23","author":"Doll, R.","year":"1969","unstructured":"Doll R. The geographical distribution of cancer. Br J Cancer 1969; 23: 1-8.","journal-title":"Br J Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/1097-0142(197409)34:3+<815::AID-CNCR2820340705>3.0.CO;2-6","article-title":"Bacteria and the aetiology of colonic cancer","volume":"34","author":"Hill, M.J.","year":"1974","unstructured":"Hill MJ. Bacteria and the aetiology of colonic cancer. 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Promoting effect of bile acids in colon carcinogenesis in germ free and conventional F344 rats. Cancer Res 1977; 37: 3238-42.","journal-title":"Cancer Res"},{"key":"ref_21","first-page":"495","article-title":"Faecal pH value and its modification in S. African black and white schoolchildren","volume":"55","author":"Walker, A.R.P.; Walker, B.F.; Segal, I.","year":"1979","unstructured":"Walker ARP, Walker BF, Segal I. Faecal pH value and its modification in S. African black and white schoolchildren. S Afr Med J 1979; 55: 495-8.","journal-title":"S Afr Med J"},{"key":"ref_22","first-page":"119","article-title":"Five year survival of 1,115 patients with colorectal cancer","volume":"11","author":"Stower, M.J.; Hardcastle, J.D.","year":"1985","unstructured":"Stower MJ, Hardcastle JD. Five year survival of 1,115 patients with colorectal cancer. 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[Abstract] Gut 1987; 28: A 1366.","journal-title":"[Abstract] Gut; 28: A 1366"},{"key":"ref_25","first-page":"1012","article-title":"Colonic release of 5- aminosalysilic acid from an oral preparation in active ulcerative colitis","volume":"28","author":"Dew, M.J.; Ryder, R.E.; Evans, N.","year":"1985","unstructured":"Dew MJ, Ryder RE, Evans N. Colonic release of 5- aminosalysilic acid from an oral preparation in active ulcerative colitis. Br J Clin Pharmacol 1985; 28S: 1012-4.","journal-title":"Br J Clin Pharmacol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0378-5173(87)90036-6","article-title":"Evaluation of an enteric coated Naproxen tablet using gamma scintigraphy and pH monitoring","volume":"37","author":"Hardy, J.G.; Evans, D.F.; Zaki, I.; Clarke, A.G.; Tonnensen, H.H.; Gamst, O.N.","year":"1987","unstructured":"Hardy JG, Evans DF, Zaki I, Clarke AG, Tonnensen HH, Gamst ON. Evaluation of an enteric coated Naproxen tablet using gamma scintigraphy and pH monitoring. Int J Pharm 1987; 37: 245-50.","journal-title":"Int J Pharm"},{"key":"ref_27","first-page":"43","article-title":"Ileal pH in cystic fibrosis","volume":"23","author":"Gilbert, J.; Kelleher, J.; Littlewood, J.M.; Evans, D.F.","year":"1988","unstructured":"Gilbert J, Kelleher J, Littlewood JM, Evans DF. Ileal pH in cystic fibrosis. Scand J Gastroenterol 1988; 23(suppl 43): 132-4.","journal-title":"Scand J Gastroenterol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.29.8.1035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:33:58Z","timestamp":1765661638000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.29.8.1035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,8]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1988,8,1]]},"published-print":{"date-parts":[[1988,8]]}},"alternative-id":["10.1136\/gut.29.8.1035"],"URL":"https:\/\/doi.org\/10.1136\/gut.29.8.1035","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,8]]}}}