{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:50:46Z","timestamp":1765000246766,"version":"3.46.0"},"reference-count":34,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:p>Gastric biopsies from 86 patients with pernicious anaemia were examined for Campylobacter like organisms with particular attention to those showing an antral gastritis in addition to the usual pattern of body gastritis. All the patients had chronic atrophic gastritis in the body but Campylobacter like organisms were found at this site in only three patients. Thus the Type A pattern of gastritis (autoimmune) seen in patients with pernicious anaemia is only rarely associated with Campylobacter like organisms. Forty four of these patients had biopsies from body and antrum, 16 showed an antral gastritis of whom only one had Campylobacter like organism present. Twenty five of this latter group of patients were rebiopsied after five years. There was no change in the pattern of gastritis, and the same single patient remained colonised. The frequency of an antral gastritis in patients with pernicious anaemia was 36% yet the frequency of antral colonisation by Campylobacter like organisms was very low (6%). These results show that, as in the body, Campylobacter like organisms are not associated with gastritis when it occurs at this site in pernicious anaemia. The antral gastritis that may accompany body gastritis in pernicious anaemia seems more likely therefore to be an extension of primary type A body gastritis (autoimmune) rather than a secondary type B (chronic) gastritis and, it is argued, the antrum may exhibit resistance to colonisation.<\/jats:p>","DOI":"10.1136\/gut.30.1.60","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"60-64","source":"Crossref","is-referenced-by-count":63,"title":["Pernicious anaemia and Campylobacter like organisms; is the gastric antrum resistant to colonisation?"],"prefix":"10.1136","volume":"30","author":[{"given":"J F","family":"Flejou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bahame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W","family":"Stockbrugger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A B","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"i:","author":"Marshall, B.J.; Warren, JR","year":"1984","unstructured":"Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; i: 1311-5.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/jcp.37.9.1002","article-title":"Campylobacter like organisms on the gastric mucosa: Culture, histological and seriological studies","volume":"37","author":"Jones, D.M.; Lessels, A.M.; Eldridge, J.","year":"1984","unstructured":"Jones DM, Lessels AM, Eldridge J. Campylobacter like organisms on the gastric mucosa: Culture, histological and seriological studies. J Clin Pathol 1984; 37: 1002-6.","journal-title":"J Clin Pathol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1136\/gut.26.11.1183","article-title":"Campylobacter pyloridis in peptic ulcer disease: microbiology, pathology and scanning electron microscopy","volume":"26","author":"Price, A.; Levi, J.; Dolby, J.M.","year":"1985","unstructured":"Price A, Levi J, Dolby JM, et al. 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Front Gastrointestinal Res 1980; 6: 98-108.","journal-title":"Front Gastrointestinal Res"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0046-8177(75)80177-8","article-title":"Atrophic gastritis","volume":"6","author":"Glass, G.B.J.; Pitchumoni, C.S.","year":"1975","unstructured":"Glass GBJ, Pitchumoni CS. Atrophic gastritis. Hum Pathol 1975; 6: 219-50.","journal-title":"Hum Pathol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.5694\/j.1326-5377.1985.tb113443.x","article-title":"Attempt to fulfil Koch's postulates for pyloric campylobacter","volume":"142","author":"Marshall, B.J.; Armstrong, J.A.; McGechie, D.B.; Glancy, R.J.","year":"1985","unstructured":"Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ. Attempt to fulfil Koch's postulates for pyloric campylobacter. 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Campylobacter like organisms in the stomach of patients and healthy individuals. Lancet 1984; i: 1348.","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/gut.17.7.551","article-title":"Gastric morphology and serum gastrin levels in pernicious anaemia","volume":"17","author":"Lewin, K.J.; Dowling, F.; Wright, J.P.; Taylor, K.B.","year":"1976","unstructured":"Lewin KJ, Dowling F, Wright JP, Taylor KB. Gastric morphology and serum gastrin levels in pernicious anaemia. Gut 1976; 17: 551-60.","journal-title":"Gut"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1136\/gut.24.12.1141","article-title":"Gastroscopic screening in 80 patients with pernicious anaemia","volume":"24","author":"Stockbrugger, R.W.; Menon, G.G.; Beilby, J.O.W.; Mason, R.R.; Cotton, P.B.","year":"1983","unstructured":"Stockbrugger RW, Menon GG, Beilby JOW, Mason RR, Cotton PB. 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Gastritis and duodenitis. In: Appelman HD, ed. Pathology of the oesophagus, stomach and duodenum. New York: Churchill Livingstone, 1984: 37-77."},{"key":"ref_23","first-page":"113","article-title":"Chronic gastritis","volume-title":"Textbook of gastroenterology","author":"Strickland, R.G.","year":"1986","unstructured":"Strickland RG. Chronic gastritis. In: Bouchier IAD, Allan RN, Hodgson HFJ, Keighley MRD, eds. Textbook of gastroenterology. London: Bailliere Tindall, 1986: 113-25."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/gut.27.10.1132","article-title":"Campylobacter like organisms in duodenal and antral endoscopic biopsies: relationship to inflammation","volume":"27","author":"Johnston, B.J.; Reed, P.I.; Ali, M.H.","year":"1986","unstructured":"Johnston BJ, Reed PI, Ali MH. Campylobacter like organisms in duodenal and antral endoscopic biopsies: relationship to inflammation. Gut 1986; 27: 1132-7.","journal-title":"Gut"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/path.1711460409","article-title":"The gastro-duodenal epithelium in peptic ulceration","volume":"146","author":"Steer, H.W.","year":"1985","unstructured":"Steer HW. The gastro-duodenal epithelium in peptic ulceration. J Pathol 1985; 146: 355-62.","journal-title":"J Pathol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1136\/jcp.40.8.841","article-title":"Campylobacter pyloridis and acid-induced gastric metaplasia in the pathogenesis of duodenitis","volume":"40","author":"Wyatt, J.; Rathbone, B.J.; Dixon, M.F.; Heatley, R.V.","year":"1987","unstructured":"Wyatt J, Rathbone BJ, Dixon MF, Heatley RV. Campylobacter pyloridis and acid-induced gastric metaplasia in the pathogenesis of duodenitis. J Clin Pathol 1987; 40: 841-8.","journal-title":"J Clin Pathol"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/jcp.38.8.946","article-title":"Microbial and metabolic profile of achlorhydric stomach: comparison of pernicious anaemia and hypogammaglobulinaemia","volume":"38","author":"Borriello, S.P.; Reed, P.J.; Dolby, J.M.; Barclay, F.E.; Webster, A.D.B.","year":"1985","unstructured":"Borriello SP, Reed PJ, Dolby JM, Barclay FE, Webster ADB. Microbial and metabolic profile of achlorhydric stomach: comparison of pernicious anaemia and hypogammaglobulinaemia. J Clin Pathol 1985; 38: 946-53.","journal-title":"J Clin Pathol"},{"key":"ref_28","first-page":"1387","volume":"40","author":"Tompkins, D.S.; pylori, West A.P.Campylobacter; acid; bile","year":"1987","unstructured":"Tompkins DS, West AP. Campylobacter pylori, acid, and bile. J Clin Pathol 1987; 40: 1387.","journal-title":"J Clin Pathol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0140-6736(86)92561-4","article-title":"Campylobacter pyloridis, urease, hydrogen ion back diffusion and gastric ulcers","volume":"ii:","author":"Hazell, S.L.; Lee, A.","year":"1986","unstructured":"Hazell SL, Lee A. Campylobacter pyloridis, urease, hydrogen ion back diffusion and gastric ulcers. Lancet 1986; ii: 15-7.","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/jcp.41.1.112-a","article-title":"Urease activity of Campylobacter pylori","volume":"41","author":"Taylor, M.; Karim, Q.N.","year":"1988","unstructured":"Taylor M, Karim QN. Urease activity of Campylobacter pylori. J Clin Pathol 1988; 41: 112.","journal-title":"J Clin Pathol"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/0016-5085(79)90415-3","article-title":"Epidemic gastritis with hypochlorhydria","volume":"76","author":"Ramsay, E.J.; Carey, K.V.; Peterson, W.L.","year":"1979","unstructured":"Ramsay EJ, Carey KV, Peterson WL, et al. Epidemic gastritis with hypochlorhydria. Gastroenterology 1979; 76: 1449-57.","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/jcp.39.4.353","article-title":"Campylobacter pyloridis, gastritis, and peptic ulceration","volume":"39","author":"Goodwin, C.S.; Armstrong, J.A.; Marshall, B.J.","year":"1986","unstructured":"Goodwin CS, Armstrong JA, Marshall BJ. Campylobacter pyloridis, gastritis, and peptic ulceration. J Clin Pathol 1986; 39: 353-65.","journal-title":"J Clin Pathol"},{"key":"ref_33","first-page":"1109","article-title":"Campylobacter pylori and recurrence of duodenal ulcers -","volume":"ii:","author":"Coghlan, J.G.; Gilligan, D.; Humphries, D.","year":"1987","unstructured":"Coghlan JG, Gilligan D, Humphries D, et al. Campylobacter pylori and recurrence of duodenal ulcers - a 12 month follow-up study. Lancet 1987; ii: 1109-11."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/gut.29.7.909","article-title":"Campylobacterpylori in a sample of Finnish population: relations to morphology and function of the gastric mucosa","volume":"29","author":"Siurala, M.; Sipponen, P.; Kekki, M.","year":"1988","unstructured":"Siurala M, Sipponen P, Kekki M. Campylobacterpylori in a sample of Finnish population: relations to morphology and function of the gastric mucosa. Gut 1988; 29: 909-15.","journal-title":"Gut"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.30.1.60","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:45:26Z","timestamp":1764999926000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.30.1.60"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1989,1,1]]},"published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1136\/gut.30.1.60"],"URL":"https:\/\/doi.org\/10.1136\/gut.30.1.60","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}