{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:40:20Z","timestamp":1765640420389,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:p>In a randomised, double blind, parallel group study in patients with symptomatic gastric ulcer (94% greater than or equal to 5 mm diameter), 102 received omeprazole 20 mg om and 87 cimetidine 400 mg bd. After four weeks 73% and 58% (p less than 0.05) respectively had healed (eight weeks: 84% and 75%, ns). After four weeks, a greater proportion (81%) of omeprazole treated patients was symptom free than of those receiving cimetidine (60%; p less than 0.01). Over the first two weeks, patients receiving omeprazole had less day pain, less night pain and took fewer antacids than those receiving cimetidine (all p less than 0.05). The difference between omeprazole and cimetidine was not appreciably affected by age, smoking, size of the ulcer and trial centre. Tolerability was similar in the two treatment groups. In the treatment of symptomatic gastric ulcer, omeprazole relieves the symptoms more quickly than cimetidine and heals a greater proportion of ulcers within four weeks.<\/jats:p>","DOI":"10.1136\/gut.30.10.1323","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1323-1328","source":"Crossref","is-referenced-by-count":26,"title":["Randomised, double blind comparison of omeprazole and cimetidine in the treatment of symptomatic gastric ulcer."],"prefix":"10.1136","volume":"30","author":[{"given":"C M","family":"Bate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S P","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G V","family":"Bradby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Bateson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W S","family":"Hislop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C P","family":"Willoughby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M","family":"Peers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P D","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,10,1]]},"reference":[{"key":"ref_1","first-page":"270","article-title":"Fffect of omcprazolc - a gastric proton puimp inhibitoI on pentagastrin StimuLlated acid secrction in m.lan","volume-title":"Gui","volume":"24","year":"1983","unstructured":"Lind 1, Ccderlberg C. Ekenved G, Haglund K, Olbc L. Fffect of omcprazolc - a gastric proton puimp inhibitoI on pentagastrin StimuLlated acid secrction in m.lan. Gui 1983; 24: 270-6."},{"issue":"8-1","key":"ref_2","first-page":"3","article-title":"A comparison of two ditfcient doscs of omcprazolc VeISus ranitidine in treatmcnt of duodenal ulcers","volume":"4","author":"Kl), Bardhan; Ci, Bianchi Porro; K, Bosc","year":"1986","unstructured":"Bardhan Kl), Bianchi Porro Ci, Bosc K. et al. A comparison of two ditfcient doscs of omcprazolc VeISus ranitidine in treatmcnt of duodenal ulcers. (J J in Gastr.osienterol 1986; 8: 4t8-1 3.","journal-title":"(J J in Gastr.osienterol"},{"key":"ref_3","first-page":"243","article-title":"Omcprazole heals duodenal but not gastric ulccrs morc rapidly than rianitidine","volume":"i","author":"H-G, Classen M.D.)ammarnn; W, Domschkc","year":"1985","unstructured":"Classen M. D)ammarnn H-G, Domschkc W, i ail. Omcprazole heals duodenal but not gastric ulccrs morc rapidly than rianitidine. Hepaitogastiroetrolog,v 1985; 32: 243-5.","journal-title":"Hepaitogastiroetrolog"},{"key":"ref_4","first-page":"69","article-title":"it til. Effect of omepr-azole and ranitidinc on ulcer healing and relapse rates in patients with benign galstric ulcer","volume":"320","author":"Walan, A.; Bader, J.P.; Classcn, M.","year":"1989","unstructured":"Walan A, Bader JP, Classcn M, it til. Effect of omepr-azole and ranitidinc on ulcer healing and relapse rates in patients with benign galstric ulcer. N Fenlg Mecd 1989; 320: 69-75.","journal-title":"N Fenlg Mecd"},{"article-title":"Omeprazole 20 mg om and r'anitidine 150 mg bd in the healing of benign gastric ulcers [Abstract Guit 1987; 28: A 1341","author":"Barbara, L.; Saggioro, A.; Olisson, J.; Cisternino, M.; Fr, anceschi M.","key":"ref_5","unstructured":"Barbara L, Saggioro A, Olisson J, Cisternino M, Fr;anceschi M. Omeprazole 20 mg om and r'anitidine 150 mg bd in the healing of benign gastric ulcers [Abstract Guit 1987; 28: A 1341."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/gut.25.9.957","article-title":"Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity","volume":"25","author":"Sharmaz, B.K.; Wtalt, R.P.; Pounder, R.E.; MdeFA, Gomes; Wood, E.C.; Logan, L.H.","year":"1984","unstructured":"Sharmaz BK, Wtalt RP, Pounder RE, Gomes MdeFA, Wood EC, Logan LH. Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity. Gut 1984; 25: 957-64.","journal-title":"Gut"},{"key":"ref_7","first-page":"24953","article-title":"Fffect ot' omepr; azole and cimetidine on prepyloric gastric ulcer: double blind comparative, trial","volume":"i","author":"Lauritsen, K.; Rune, S.J.; Wulff, H.R.","year":"1988","unstructured":"Lauritsen K, Rune SJ, Wulff HR. i til. Fffect ot' omepr;azole and cimetidine on prepyloric gastric ulcer: double blind comparative, trial. Gutt 1988; 29: 24953.","journal-title":"Gutt"},{"key":"ref_8","first-page":"573","article-title":"Hcaling of benign gastric ulce:-comparison of cimetidine and placebo in the United Statcs","volume":"102","author":"Graham, D.Y.; Akdamar, K.; D)yck, W.P.; t til","year":"1985","unstructured":"Graham DY, Akdamar K, D)yck WP, t til. Hcaling of benign gastric ulce:-comparison of cimetidine and placebo in the United Statcs. Anni Ictrteai McM 1985; 102: 573-6.","journal-title":"Anni Ictrteai McM"},{"issue":"6","key":"ref_9","first-page":"19","article-title":"TFhe treatment of gastric ulcer with antisecretorY drugs; relationship of pharmacological effect to healing iate","volume":"33","year":"1988","unstructured":"() How.len CW, Jones [)B, Peace KF, Burget DW, Hunit RH. TFhe treatment of gastric ulcer with antisecretorY drugs; relationship of pharmacological effect to healing iate. I)ilDis Sci 1988; 33: 6 19-24.","journal-title":"I)ilDis Sci"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.30.10.1323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:35:24Z","timestamp":1765640124000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.30.10.1323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":9,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1989,10,1]]},"published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1136\/gut.30.10.1323"],"URL":"https:\/\/doi.org\/10.1136\/gut.30.10.1323","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1989,10]]}}}