{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T20:23:57Z","timestamp":1779049437323,"version":"3.51.4"},"reference-count":16,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p>Patterns of oesophageal motility were recorded in 17 healthy volunteers and 12 patients with the irritable bowel syndrome. Recordings were taken at rest and under stress by hyperventilation, a dichotic hearing challenge and a cold pressor test. In healthy volunteers the dichotic hearing challenge was associated with a significant increase in the mean amplitude of oesophageal peristalsis from 69.9 mmHg to 82.4 mmHg (p less than 0.01) and in the percentage of simultaneous waves from 9.7% to 24.5% (p less than 0.01). The cold pressor test increased the peristaltic amplitude from 69.9 mmHg to 87.1 mmHg (p less than 0.001) and the percentage of simultaneous waves from 9.7% to 34.4% (p less than 0.01). Both manoeuvres were associated with increases in pulse and blood pressure. In patients with irritable bowel syndrome, the resting mean oesophageal peristaltic amplitude was higher than that seen in normal volunteers (95.9 mmHg v 69.9 mmHg p less than 0.05). Changes in oesophageal motility during stress were similar in these patients to those seen in normal subjects although the changes were not significant. This study refutes the hypothesis that symptoms of irritable bowel syndrome and their association with stress are attributable to increased sensitivity of oesophageal motility to disruption by stressful stimuli.<\/jats:p>","DOI":"10.1136\/gut.30.11.1540","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1540-1543","source":"Crossref","is-referenced-by-count":29,"title":["Stress and oesophageal motility in normal subjects and patients with irritable bowel syndrome."],"prefix":"10.1136","volume":"30","author":[{"given":"R C","family":"Ayres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Naylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C L","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF01300697","article-title":"Psychological comparison of paticnts with nutcracker oesophagus and irritablc bowel syndromc","volume":"31","author":"JE, I.Richter; WF, Obrecht; LA, Bradley; LD, Young; KO, Anderson","year":"1986","unstructured":"I Richter JE, Obrecht WF, Bradley LA, Young LD, Anderson KO. Psychological comparison of paticnts with nutcracker oesophagus and irritablc bowel syndromc. Dig Dis Sci 1986; 31: 131-8.","journal-title":"Dig Dis Sci"},{"key":"ref_2","first-page":"404","article-title":"Irritabic bowel syndromc. Physiological and psychological differcnces betwcen diarrhoca-predominant and constipation-predominant paticnts","volume":"25","author":"Whitehead, W.E.; Engel, B.T.; Schustcr, M.M.","year":"1980","unstructured":"Whitehead WE, Engel BT, Schustcr MM. Irritabic bowel syndromc. Physiological and psychological differcnces betwcen diarrhoca-predominant and constipation-predominant paticnts. Dig Dis S'ci 1980; 25: 404-13.","journal-title":"Dig Dis S'ci"},{"key":"ref_3","first-page":"452","article-title":"Psychological significancc of the irritabic colon syndrome","volume":"12","author":"Hislop, I.G.","year":"1971","unstructured":"Hislop IG. Psychological significancc of the irritabic colon syndrome. Gui 1971; 12: 452-7.","journal-title":"Gui"},{"key":"ref_4","first-page":"568","article-title":"Strcss in the hcalthy oesophagus","volume":"29","author":"Obrecht, W.F.; Richter, J.E.","year":"1984","unstructured":"Obrecht WF, Richter JE. Strcss in the hcalthy oesophagus [Abstract]. Dig Dis Sci 1984; 29: 568A.","journal-title":"Dig Dis Sci"},{"key":"ref_5","first-page":"277","article-title":"Perturbation of upper G6 function by cold stress","volume":"24","author":"Thompson, D.G.; Malagelada, JR, Richelson E.","year":"1983","unstructured":"Thompson DG, Richelson E. Malagelada JR. Perturbation of upper G6 function by cold stress. Guii 1983; 24: 277-83.","journal-title":"Guii"},{"key":"ref_6","first-page":"23640","article-title":"Psychological stress and the passage of a standard meal through the stomach and small intcstine in man","volume":"24","author":"Cann, P.A.; Rcad, N.W.; Cammack, J.; eI il","year":"1983","unstructured":"Cann PA, Rcad NW, Cammack J, eI il. Psychological stress and the passage of a standard meal through the stomach and small intcstine in man. Glli 1983; 24: 23640.","journal-title":"Glli"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0140-6736(85)90525-2","article-title":"The irritable bowel syndromc: a paroxysmal motor disorder","volume":"ii:","author":"Kumar, D.; Wingate, D.L.","year":"1985","unstructured":"Kumar D, Wingate DL. The irritable bowel syndromc: a paroxysmal motor disorder. Lancet 1985; ii: 973-7.","journal-title":"Lancet"},{"key":"ref_8","first-page":"526","article-title":"Mcasurement of UES pressure - Effcct of acute emotional strcss","volume":"93","author":"Cook, I.J.; Dent, J.; Shannon, S.; Collins, S.M.","year":"1987","unstructured":"Cook IJ, Dent J, Shannon S, Collins SM. Mcasurement of UES pressure - Effcct of acute emotional strcss. Gasti-oenterology 1987; 93: 526-32.","journal-title":"Gasti-oenterology"},{"key":"ref_9","first-page":"827","article-title":"Incidencc of oesophageal symptoms in patients with irritabic bowel syndrome lAbstract]","volume":"17","author":"Watson, W.C.; Sullivan, S.N.; Corke, M.; Rush, D.","year":"1976","unstructured":"Watson WC, Sullivan SN, Corke M, Rush D. Incidencc of oesophageal symptoms in patients with irritabic bowel syndrome lAbstract]. Gut 1976; 17: 827A."},{"key":"ref_10","first-page":"1101","article-title":"Ocsophageal motility in the irritable bowel syndrome","volume":"282","author":"Whorwell, P.J.; Clouter, C.; Smith, C.L.","year":"1981","unstructured":"Whorwell PJ, Clouter C, Smith CL. Ocsophageal motility in the irritable bowel syndrome. Br Me(IJ 1981; 282: 1101-2.","journal-title":"Br Me(IJ"},{"issue":"10","key":"ref_11","first-page":"1931","article-title":"Obscrvations on the mechanisms of abdominal pain","volume":"1969","author":"Holdstock, D.J.; Misiewicz, J.J.; Waller, S.L.","unstructured":"Holdstock DJ, Misiewicz JJ, Waller SL. Obscrvations on the mechanisms of abdominal pain. Gui 1969; 10: 1931.","journal-title":"Gui"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0140-6736(79)92811-3","article-title":"Abnormal small-bowel motility demonstrated by radiotelemetry in a patient with irritable colon","volume":"ii:","author":"Thompson, D.G.; Laidlow, J.M.; Wingate, D.L.","year":"1979","unstructured":"Thompson DG, Laidlow JM, Wingate DL. Abnormal small-bowel motility demonstrated by radiotelemetry in a patient with irritable colon. Lancet 1979; ii: 1321-3.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0016-5085(76)80141-2","article-title":"Colonic myoelectrical activity in the irritable bowel syndrome","volume":"70","author":"Snape, W.J.; Carlson, G.M.; Cohen, S.","year":"1970","unstructured":"Snape WJ, Carlson GM, Cohen S. Colonic myoelectrical activity in the irritable bowel syndrome. Gastiroenterology 1970; 70: 326-30.","journal-title":"Gastiroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1136\/bmj.284.6330.1670","article-title":"Functional abdominal pain: further evidence that the whole gut is affected","volume":"284","author":"Moriarty, K.J.; Dawson, A.M.","year":"1982","unstructured":"Moriarty KJ, Dawson AM. Functional abdominal pain: further evidence that the whole gut is affected. Br MecdJ 1982; 284: 1670-2.","journal-title":"Br MecdJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/gut.14.2.125","article-title":"Pain from distension of the peivic colon by inflating a balloon in the irritable bowel syndrome","volume":"14","author":"Ritchie, J.A.","year":"1973","unstructured":"Ritchie JA. Pain from distension of the peivic colon by inflating a balloon in the irritable bowel syndrome. Gut 1973; 14:125-32.","journal-title":"Gut"},{"key":"ref_16","first-page":"371","article-title":"Esophageal function in elderly men: a new look at presbyesophagus","volume":"80","author":"Hollis, J.B.; Castell, D.O.","year":"1974","unstructured":"Hollis JB, Castell DO. Esophageal function in elderly men: a new look at presbyesophagus. Ann Intern Med 1974;80:371-4."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.30.11.1540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:08:53Z","timestamp":1765602533000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.30.11.1540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1989,11,1]]},"published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1136\/gut.30.11.1540"],"URL":"https:\/\/doi.org\/10.1136\/gut.30.11.1540","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}