{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T16:00:18Z","timestamp":1765641618158,"version":"3.48.0"},"reference-count":12,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p>The incidence of pancreatic cancer is increased in patients who have undergone gastric surgery. An animal model is described in which pancreatic hyperplasia and adenoma formation developed within 56 weeks. The effects of a simple gastrojejunostomy were compared with those after a split gastrojejunostomy, in which the jejunum was transected and the two limbs implanted separately into the greater curvature of the glandular stomach 1 cm apart. After 56 weeks no animals in the simple gastrojejunostomy group had pancreatic hyperplasia whereas all 10 animals in the split gastrojejunostomy group had generalised pancreatic hyperplasia with macroscopic nodules. Microscopy of the nodules showed that in nine animals hyperplastic nodules had developed, and four of these also had adenomatous nodules. The remaining animal had enlarged lymph nodes. Pancreatic hyperplasia was associated with jejunal hyperplasia. Jejunal morphometry showed that the villus height was doubled and the villus height:crypt depth ratio was higher in the split gastrojejunostomy group compared with those animals with a simple gastrojejunostomy. This finding represents a new model for the investigation of pancreatic neoplastic change.<\/jats:p>","DOI":"10.1136\/gut.30.11.1596","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1596-1600","source":"Crossref","is-referenced-by-count":14,"title":["Induction of pancreatic tumours by longterm duodenogastric reflux."],"prefix":"10.1136","volume":"30","author":[{"given":"P R","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R H","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T J","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D C","family":"Hanley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"McColl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/gut.28.8.924","article-title":"Incrcascd risk ot canccr at multiplc sitcs aftcr gastric surgery lor pcptic ulcer","volume":"28","author":"CPJ, I.Caygill; MJ, Hill; CN, Hall","year":"1987","unstructured":"I Caygill CPJ, Hill MJ, Hall CN, et al. Incrcascd risk ot canccr at multiplc sitcs aftcr gastric surgery lor pcptic ulcer. Guit 1987; 28: 924-8.","journal-title":"Guit"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/BF01655015","article-title":"Opcration scqucl carcinoma of the stomach. Experimental situdies of surgical tcchniques with or without rescction","volume":"5","author":"R, Langhans P.Heger; J, Hohenstein; it al","year":"1981","unstructured":"Langhans P. Heger R, Hohenstein J, it al. Opcration scqucl carcinoma of the stomach. Experimental situdies of surgical tcchniques with or without rescction. World]J Surg 1981; 5: 595-605.","journal-title":"World]J Surg"},{"key":"ref_3","first-page":"801","article-title":"Duodenogastric reflux in rat gastric carcinoma","volume-title":"Br]J Sarg","volume":"73","author":"Mason, R.C.","year":"1986","unstructured":"Mason RC. Duodenogastric reflux in rat gastric carcinoma. Br]J Sarg 1986-; 73: 801-3."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10520298409113822","article-title":"Simultancous demonstration of connectivc tissuc elastic and fibrin by a combincd Vcrhocff's Elastica-Martius-Scariet-Bluc trichome stain","volume":"59","author":"Buk, S.J.A.","year":"1984","unstructured":"Buk SJA. Simultancous demonstration of connectivc tissuc elastic and fibrin by a combincd Vcrhocff's Elastica-Martius-Scariet-Bluc trichome stain. Stain Technol 1984; 59: 1-5.","journal-title":"Stain Technol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/00365527909179873","article-title":"Carcinogenic effccts of di(2-hydroxypropyl)nitrosaminc (DHPH) in malc Wistar rats: promotion of pancrcatic cancer by soya flour dict","volume":"14","author":"Levison, D.A.; Morgan, R.G.H.; Brimacombc, J.S.; it al","year":"1979","unstructured":"Levison DA, Morgan RGH, Brimacombc JS, it al. 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Effect of duodenogastric rcflux on gastric mucosal proliferation aftcr gastric surgery. Br \/ Suarg 1987; 74: 288-91.","journal-title":"Br \/ Suarg"},{"key":"ref_8","first-page":"15","article-title":"Enhancement of pancrcatic cnzymc synthcsis by pancreozymin","volume":"2","author":"Rothman, S.S.; Wclls, H.","year":"1967","unstructured":"Rothman SS, Wclls H. Enhancement of pancrcatic cnzymc synthcsis by pancreozymin. Am J !lhysio 1967; 13: 2 15-8.","journal-title":"Am J !lhysio"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1080\/00365521.1974.12096895","article-title":"Pancreatic secretion of enzymes in rats treated with soy bean diet","volume":"9","author":"Folsch, U.R.; Wormsley, K.G.","year":"1974","unstructured":"Folsch UR, Wormsley KG. Pancreatic secretion of enzymes in rats treated with soy bean diet. Scand J Gastroenterol 1974; 9: 679-83.","journal-title":"Scand J Gastroenterol"},{"key":"ref_10","first-page":"889","article-title":"Soya-induced pancreatic hypertrophy and rise of circulating cholecystokinin","volume":"23","author":"Adrian, T.E.; Pasquali, C.; Pescosta, F.","year":"1982","unstructured":"Adrian TE, Pasquali C, Pescosta F, et al. Soya-induced pancreatic hypertrophy and rise of circulating cholecystokinin [Abstract]. Glut 1982; 23: A889.","journal-title":"Glut"},{"issue":"1","key":"ref_11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/gut.28.Suppl.265","article-title":"Long term pancreaticobiliary diversion stimulates hyperplastic and adenomatous nodules in the rat pancreas: a new model for spontaneous tumour formation","volume":"28","author":"Stace, N.H.; Vaja, Palmer T.J.I.; S.","year":"1987","unstructured":"Stace NH, Palmer TJI Vaja S. et al. 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