{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:10:11Z","timestamp":1764997811812,"version":"3.46.0"},"reference-count":15,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:p>The efficacy of ranitidine (150 mg nocte), and sucralfate (1 g tds) as maintenance therapy to prevent gastric ulcer relapse was evaluated in a 12 month trial in 363 patients. The relapse rates were 8.8% at three months, 14.7% at six months, 18.1% at nine months, and 21.0% at 12 months for the ranitidine group and 14.7%, 21.3%, 29.9%, and 30.2% respectively for the sucralfate group. At nine and 12 months the cumulative relapse rates for the ranitidine group were significantly lower than those for the sucralfate group (p less than 0.05). In both groups ulcers recurred mainly from red scars observed at the endoscopic scarring stage. This indicated the necessity of drug treatment up to the white scar stage. The results suggest that ranitidine is effective in preventing gastric ulcer relapse.<\/jats:p>","DOI":"10.1136\/gut.30.12.1692","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1692-1697","source":"Crossref","is-referenced-by-count":13,"title":["Ranitidine and sucralfate as maintenance therapy for gastric ulcer disease: endoscopic control and assessment of scarring."],"prefix":"10.1136","volume":"30","author":[{"given":"T","family":"Takemoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Namiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Tsuneoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Oshiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,12,1]]},"reference":[{"key":"ref_1","first-page":"158","article-title":"Double-blind comparison of cimctidine and placebo in the maintenance of healing of chronic duodenal ulceration","volume":"20","author":"KD, I.Bardhan; DM, Saul; JL, Edwards","year":"1979","unstructured":"I Bardhan KD, Saul DM, Edwards JL, et al. Double-blind comparison of cimctidine and placebo in the maintenance of healing of chronic duodenal ulceration. Gti 1979; 20: 158-62.","journal-title":"Gti"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/gut.23.3.239","article-title":"Bedtime cimetidine maintenance treatment: optimum dose and effect on subsequent natural history of duodenal ulcer","volume":"23","author":"Fitzpatrick, W.J.F.; Blackwood, W.S.; Northfield, T.C.","year":"1982","unstructured":"Fitzpatrick WJF, Blackwood WS, Northfield TC. Bedtime cimetidine maintenance treatment: optimum dose and effect on subsequent natural history of duodenal ulcer. Gut 1982: 23: 239-42.","journal-title":"Gut"},{"issue":"38","key":"ref_3","first-page":"341","article-title":"Maintenance therapy with ranitidine following healing of acute duodenal ulcer","volume":"1985","author":"Kozarek, R.; Berenson, M.; Berkowitz, J.","unstructured":"Kozarek R, Berenson M, Berkowitz J, et al. Maintenance therapy with ranitidine following healing of acute duodenal ulcer. C'turr Tlier Res 1985: 38: 341-5 1.","journal-title":"C'turr Tlier Res"},{"issue":"4","key":"ref_4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0002-9343(86)90597-8","article-title":"Maintenance therapy of duodenal ulcer with famotidine. A multicenter United States Study","volume":"81","author":"Texter, E.C.; Navab, F.; Mantell, G.; Berman, R.","year":"1986","unstructured":"Texter EC, Navab F, Mantell G, Berman R. Maintenance therapy of duodenal ulcer with famotidine. A multicenter United States Study. Am J Med 1986; 81 [suppl 4B1: 25-32.","journal-title":"Am J Med"},{"article-title":"Principles ofgastroenterological en(doscopy (in Japanese)","author":"Sakita, T.","key":"ref_5","unstructured":"Sakita T. Principles ofgastroenterological en(doscopy (in Japanese). Tokyo: Chugai-Igaku C, 1970: 32."},{"key":"ref_6","first-page":"659","article-title":"Ranitidine and cimetidinc in prevention of duodenal ulcer relapse. A doubie-blind. randomised. multicenter. comparative trial","volume":"ii:","author":"Gough, K.R.; Korman, M.G.; Bardhan, K.D.","year":"1984","unstructured":"Gough KR, Korman MG, Bardhan KD. et al. Ranitidine and cimetidinc in prevention of duodenal ulcer relapse. A doubie-blind. randomised. multicenter. comparative trial. Lancet 1984; ii: 659-62.","journal-title":"Lancet"},{"key":"ref_7","first-page":"7","article-title":"Final report on the United States multicenter trial comparing ranitidine to cimetidine as maintenance therapy following healing of duodenal ulcer","volume":"1985","author":"Silvis, S.E.","unstructured":"Silvis SE. Final report on the United States multicenter trial comparing ranitidine to cimetidine as maintenance therapy following healing of duodenal ulcer. J Clini Gaistoe(nterol 1985: 7: 482-7.","journal-title":"J Clini Gaistoe(nterol"},{"key":"ref_8","first-page":"122","article-title":"Intragastric acidity during duodenal ulcer maintenance treatment with H, blockers","volume":"1","author":"R, Santana I.A.Pounder R.E.Orchard K.Wood E.C.Chronos N.Neame","year":"1986","unstructured":"Santana IA. Pounder RE. Orchard K. Wood EC. Chronos N. Neame R. Intragastric acidity during duodenal ulcer maintenance treatment with H, blockers. J C\/lin Nuti Gastiroenterol 1986; 1: 122-6.","journal-title":"J C\/lin Nuti Gastiroenterol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0016-5085(83)80235-2","article-title":"A two-year prospective controlled study of maintenance cimetidine and gastric ulcer","volume":"85","author":"Barr, G.D.; Canalese, Kang J.Y.; J, Piper; D.W.","year":"1983","unstructured":"Barr GD, Kang JY. Canalese J, Piper DW. A two-year prospective controlled study of maintenance cimetidine and gastric ulcer. Gastiroenterology 1983; 85: 100-4.","journal-title":"Gastiroenterology"},{"issue":"26","key":"ref_10","first-page":"5996012","article-title":"Maintenance therapy: a two year comparison between Caved-S and cimetidine treatment in the prevention of symptomatic gastric ulcer recurrence","volume":"1985","author":"t) Morgan AG; G, Pacsoo; WAF, McAdam","unstructured":"t) Morgan AG, Pacsoo G, McAdam WAF. Maintenance therapy: a two year comparison between Caved-S and cimetidine treatment in the prevention of symptomatic gastric ulcer recurrence. Gut 1985: 26: 5996012.","journal-title":"Gut"},{"key":"ref_11","series-title":"Proceedings of an International Symposium held in the context of the seventh world congress of gastroenterology","first-page":"102","article-title":"Maintenance treatment of duodenal and gastric ulcer with ranitidine. Ranitidine","author":"Boyd, E.J.S.; Wilson, J.A.; Wormsley, K.G.","year":"1982","unstructured":"Boyd EJS, Wilson JA, Wormsley KG. Maintenance treatment of duodenal and gastric ulcer with ranitidine. Ranitidine Proceedings of an International Symposium held in the context of the seventh world congress of gastroenterology, Stockholm, 17 June 1982, Amsterdam. 1982: 102."},{"key":"ref_12","first-page":"232","article-title":"Ranitidine in the long-term treatment of gastric ulcers. The clinical use of ranitidine","volume-title":"The Medicine Publishing Foundation Symposium Series 5","volume":"1982","author":"Cockel, R.; Dawson, J.; Jain, S.","unstructured":"Cockel R, Dawson J, Jain S. Ranitidine in the long-term treatment of gastric ulcers. The clinical use of ranitidine. Oxford: The Medicine Publishing Foundation Symposium Series 5, 1982: 232."},{"key":"ref_13","first-page":"1","article-title":"Endoscopic evaluation of the effect of sucralfate therapy and other clinical parameters on the recurrcnce rate of gastric ulccrs","volume":"25","author":"Miyake, T.; Suzukaki, Ariyoshi J.; T, Oishi; M, Sakai; M, Ucda; S.","year":"1980","unstructured":"Miyake T, Ariyoshi J Suzukaki T, Oishi M, Sakai M, Ucda S. Endoscopic evaluation of the effect of sucralfate therapy and other clinical parameters on the recurrcnce rate of gastric ulccrs. Dig INs Sci 1980; 25: 1-7.","journal-title":"Dig INs Sci"},{"issue":"1","key":"ref_14","first-page":"32","article-title":"Maintenancc therapy with sucralfate reduces rate of gastric ulccr recurrcncc","volume":"2","author":"Marks, I.N.; Wright, J.P.; Gilinsky, Girdwood A.H.; NH, Lucke; W.","year":"1985","unstructured":"Marks IN, Wright JP, Girdwood AH. Gilinsky NH, Lucke W. Maintenancc therapy with sucralfate reduces rate of gastric ulccr recurrcncc. Am J Med 1985; 79 Isuppl 2C1: 32-5.","journal-title":"Am J Med"},{"key":"ref_15","first-page":"49","article-title":"Efficacy of sucralfate in the prevention of peptic ulcer - double blind multicenter study with cimetidine","volume":"140","author":"Takemoto, T.; Kimura, K.; Okita, K.","year":"1987","unstructured":"Takemoto T, Kimura K, Okita K. et al. Efficacy of sucralfate in the prevention of peptic ulcer - double blind multicenter study with cimetidine. 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