{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:38:55Z","timestamp":1768455535794,"version":"3.49.0"},"reference-count":37,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:p>The presence of gall stones diagnosed by ultrasonography in a cross sectional study was analysed in relation to relative weight, weight change since age 25, slimming treatment, physical activity, smoking, consumption of coffee, and diabetes mellitus. The random sample comprised 4581 men and women of Danish origin, aged 30, 40, 50, and 60 years, of whom 3608 (79%) attended the investigation. In women high body mass index, history of slimming treatment, and weight gain since the age of 25 of more than 5 body mass index units were each significantly associated with gall stones (p less than 0.05), while only body mass index was significant (p less than 0.05) in a multivariate analysis. In men history of slimming treatment was significantly associated (p less than 0.05) with gall stones in univariate and in multivariate analyses, where smoking also became significantly associated (p less than 0.05). No significant association was detected between gall stones and the other variables.<\/jats:p>","DOI":"10.1136\/gut.30.4.528","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"528-534","source":"Crossref","is-referenced-by-count":137,"title":["Gall stones in a Danish population. Relation to weight, physical activity, smoking, coffee consumption, and diabetes mellitus."],"prefix":"10.1136","volume":"30","author":[{"given":"T","family":"J\u00f8rgensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0021-9681(66)90132-9","article-title":"The epidemiology of gallbladder disease: Observations in the Framingham study","volume":"19","author":"Friedman, G.D.; Kannel, W.B.; Dawber, T.R.","year":"1966","unstructured":"Friedman GD, Kannel WB, Dawber TR. The epidemiology of gallbladder disease: Observations in the Framingham study. 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J Clin Inivest 1983; 72: 1150-62.","journal-title":"J Clin Inivest"},{"key":"ref_26","first-page":"114","article-title":"Dict in the formation and treatmcnt of cholesterol gallstones","volume-title":"Contemporairv issues in gastroenterology","volume":"4","author":"Lefkof, I.R.; Marks, J.W.; Schoenfield, L.J.","year":"1985","unstructured":"Lefkof IR, Marks JW, Schoenfield LJ. Dict in the formation and treatmcnt of cholesterol gallstones. In: Cohen S, Soloway RD, eds. Gallstones. Contemporairv issues in gastroenterology. New York: Churchill Livingstonc. 1985: 4: 114."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bmj.286.6367.763","article-title":"Prevalence and treatment of gall stones after gastric bypass surgery for morbid obesity","volume":"286","author":"Wattchow, D.A.; Hall, J.C.; Whiting, M.J.; Bradley, B.; lannos J; JMcK, Watts","year":"1983","unstructured":"Wattchow DA, Hall JC, Whiting MJ, Bradley B, lannos J, Watts JMcK. Prevalence and treatment of gall stones after gastric bypass surgery for morbid obesity. Br Med J 1983; 286: 763.","journal-title":"Br Med J"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1136\/bmj.283.6303.1352","article-title":"A relation between high-density-lipoprotein cholesterol and bile cholesterol saturation","volume":"283","author":"Thornton, JR, Heaton; KW, MacFarlanc; D.G.","year":"1981","unstructured":"Thornton JR, Heaton KW, MacFarlanc DG. A relation between high-density-lipoprotein cholesterol and bile cholesterol saturation. Br Med J 1981; 283: 1352-4.","journal-title":"Br Med J"},{"key":"ref_29","first-page":"52","article-title":"Plasma lipids and insulin in gall stone discase: A case-control study","volume":"289","author":"Scragg, R.K.R.; Calvert, G.D.; Oliver, JR","year":"1984","unstructured":"Scragg RKR, Calvert GD, Oliver JR. Plasma lipids and insulin in gall stone discase: A case-control study. 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Scand J Gastroenterol 1974; 9: 3-7.","journal-title":"Scand J Gastroenterol"},{"key":"ref_32","first-page":"9602","article-title":"The lack of effect of metoclopramide on gall-bladder volume and contraction in diabetic cholecystoparesis","volume":"81","author":"Braverman, D.Z.","year":"1986","unstructured":"Braverman DZ. The lack of effect of metoclopramide on gall-bladder volume and contraction in diabetic cholecystoparesis. Atn J Gastroenterol 1986; 81: 9602.","journal-title":"Atn J Gastroenterol"},{"key":"ref_33","first-page":"357","article-title":"Gallbladder function in diabetic patients","volume":"27","author":"Shreiner, D.P.; Sarva, R.P.; Van Thiel, D.; Yingvorpant, N.","year":"1986","unstructured":"Shreiner DP, Sarva RP, Van Thiel D, Yingvorpant N. Gallbladder function in diabetic patients. J Nucl Med 1986; 27: 357-60.","journal-title":"J Nucl Med"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2337\/diab.12.4.308","article-title":"Chowers 1. Gallbladder dysfunction in diabetes mellitus. The diabetic neurogenic gall bladder","volume":"12","author":"Gitelson, S.; Schwartz, A.; Fraenkel, M.","year":"1963","unstructured":"Gitelson S, Schwartz A, Fraenkel M, Chowers 1. Gallbladder dysfunction in diabetes mellitus. The diabetic neurogenic gall bladder. Diabetes 1963; 12: 308-12.","journal-title":"Diabetes"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/BF01072357","article-title":"Bile lipid composition and bile acid pool size in diabetes","volume":"23","author":"de Leon M, Ponz; R, Ferenderes; N, Carulli","year":"1978","unstructured":"Ponz de Leon M, Ferenderes R, Carulli N. Bile lipid composition and bile acid pool size in diabetes. Dig Dis 1978; 23: 710-6.","journal-title":"Dig Dis"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1136\/gut.20.6.518","article-title":"Lipid composition of bile in diabetics and obesity-matched controls","volume":"20","author":"Haber, G.B.; Heaton, K.W.","year":"1979","unstructured":"Haber GB, Heaton KW. Lipid composition of bile in diabetics and obesity-matched controls. Gut 1979; 20: 518-22.","journal-title":"Gut"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJM197706162962401","article-title":"Effects of diabetes mellitus on cholesterol metabolism in man","volume":"296","author":"Bennion, L.J.; Grundy, S.M.","year":"1977","unstructured":"Bennion LJ, Grundy SM. Effects of diabetes mellitus on cholesterol metabolism in man. N Engl J Med 1977; 296: 1365-7 1.","journal-title":"N Engl J Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.30.4.528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:44:17Z","timestamp":1765691057000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.30.4.528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1989,4,1]]},"published-print":{"date-parts":[[1989,4]]}},"alternative-id":["10.1136\/gut.30.4.528"],"URL":"https:\/\/doi.org\/10.1136\/gut.30.4.528","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4]]}}}