{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:03:52Z","timestamp":1773273832077,"version":"3.50.1"},"reference-count":14,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:p>Conventional treatment of pancreatic steatorrhoea in man has been unsatisfactory because 90% of the lipase content of therapy is inactivated by acid in the stomach and large doses of replacement treatment are needed to provide adequate supplementation. An acid stable agent (fungal lipase) was investigated in the treatment of pancreatic deficiency steatorrhoea in 11 pancreatectomised dogs maintained on a fixed dietary intake of fat and treated with pancreatin or fungal lipase. Ten grams (60,000 U lipase) of pancreatin was compared with 400mg (4800 U lipase) of fungal lipase administered with each meal against a no treatment group. There was no significant difference in stool bulk and faecal fat excretion between pancreatin and lipase treated animals. Both groups showed a significant reduction in stool bulk and fat excretion when compared with the no treatment group (p less than 0.01). A markedly diminished treatment volume, in the form of fungal lipase, is as effective in controlling steatorrhoea as pancreatin and may prove to be a potentially valuable therapy for patients with pancreatic insufficiency.<\/jats:p>","DOI":"10.1136\/gut.30.7.1012","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1012-1015","source":"Crossref","is-referenced-by-count":30,"title":["Acid resistant lipase as replacement therapy in chronic pancreatic exocrine insufficiency: a study in dogs."],"prefix":"10.1136","volume":"30","author":[{"given":"S M","family":"Griffin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Alderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Farndon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF01296724","article-title":"Controversies in the treatment of pancreatic exocrine insufficiency","volume":"27","author":"Dimagno, E.P.","year":"1982","unstructured":"Dimagno EP. Controversies in the treatment of pancreatic exocrine insufficiency. Dig Dis Sci 1982; 27: 481-4.","journal-title":"Dig Dis Sci"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1056\/NEJM197706092962304","article-title":"Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dose schedules","volume":"296","author":"Dimagno, E.P.","year":"1977","unstructured":"Dimagno EP. Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dose schedules. N EnglJ Med 1977; 296: 1318-27.","journal-title":"N EnglJ Med"},{"key":"ref_3","first-page":"1071","article-title":"Comparitive study of varying regimens to improve steatorrhoea and creatorrhoea in cystic fibrosis: effectiveness of an enteric coated preparation with and without antacids and cimetidine","volume":"ii:","author":"Gow, R.; Francis, P.; Bradbear, R.; Shepherd, R.","year":"1981","unstructured":"Gow R, Francis P, Bradbear R, Shepherd R. Comparitive study of varying regimens to improve steatorrhoea and creatorrhoea in cystic fibrosis: effectiveness of an enteric coated preparation with and without antacids and cimetidine. Lancet 1981; ii: 1071-4.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1136\/gut.25.5.500","article-title":"Effect of intrajejunal acidity and aqueous bile acid and lipid concentrations in pancreatic steatorrhoea due to cystic fibrosis","volume":"25","author":"Zentler-Munro, P.L.","year":"1984","unstructured":"Zentler-Munro PL. Effect of intrajejunal acidity and aqueous bile acid and lipid concentrations in pancreatic steatorrhoea due to cystic fibrosis. 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Mechanism whereby cimetidine enhances pancreatic enzyme therapy. Gastroenterology. 1981; 80: 1323."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1203\/00006450-197905000-00008","article-title":"Fat digestion in the newborn. Role of lingual lipase and preduodenal digestion","volume":"13","author":"Hamosh, M.","year":"1979","unstructured":"Hamosh M. Fat digestion in the newborn. Role of lingual lipase and preduodenal digestion. Paediatr Res 1979; 13: 615-22.","journal-title":"Paediatr Res"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/bjs.1800730913","article-title":"Comparison of harvesting methods for islet transplantation","volume":"73","author":"Griffin, S.M.; Alderson, D.; Farndon, JR","year":"1986","unstructured":"Griffin SM, Alderson D, Farndon JR. Comparison of harvesting methods for islet transplantation. 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Proc Soc Exp Biol Med 1970; 135: 565-8."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1056\/NEJM197607292950503","article-title":"Hyperuricosuria due to high dose pancreatic extract therapy in cystic fibrosis","volume":"295","author":"Stapleton, F.B.; Kennedy, J.; Nousia Arvanitakis, S.; Linshaw, M.A.","year":"1976","unstructured":"Stapleton FB, Kennedy J, Nousia Arvanitakis S, Linshaw MA. Hyperuricosuria due to high dose pancreatic extract therapy in cystic fibrosis. N Engl J Med 1976; 295: 246-51.","journal-title":"N Engl J Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF01296725","article-title":"Pancreatic enzyme replacement. The effect of antacids or cimetidine","volume":"27","author":"Graham, D.Y.","year":"1982","unstructured":"Graham DY. Pancreatic enzyme replacement. The effect of antacids or cimetidine. Dig Dis Sci 1982; 27: 485-90.","journal-title":"Dig Dis Sci"},{"key":"ref_13","first-page":"778","article-title":"Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis","volume-title":"Gut","volume":"21","author":"Durie, P.; Bell, L.; Linton, W.; Covey, M.L.; Forstner, G.G.","year":"1980","unstructured":"Durie P, Bell L, Linton W, Covey ML, Forstner GG. Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. Gut 1980; 21: 778-86."},{"key":"ref_14","first-page":"97","article-title":"Pancreatic enzyme replacement therapy: comparitive effects of conventional and enteric coated microsopheric pancreatin and acid stable fungal enzyme preparations on steatorrhoea in chronic pancreatitis","volume":"32","author":"Schneider, M.U.; Knoll-Ruzicka, M.L.; Domschke, S.; Heptner, G.; Domschke, W.","year":"1985","unstructured":"Schneider MU, Knoll-Ruzicka ML, Domschke S, Heptner G, Domschke W. 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