{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:12:35Z","timestamp":1772781155735,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:p>We have applied a specific and accurate high pressure liquid chromatographic technique to determine fasting serum glycine and taurine conjugates of individual bile acids in patients with primary biliary cirrhosis before and during ursodeoxycholic acid therapy. The study was carried out in nine patients in whom the diagnosis of primary biliary cirrhosis was established according to accepted criteria. After one year of UDCA therapy liver function tests significantly improved. Total serum bile acid concentration did not change significantly (29.2 (31.5) v 28.3 (26.4) microM). Total UDCA (1.7 (2.2) v 13.3 (14.5) microM) and glyco UDCA (0.8 (1.6) v 10.9 (11.4 microM) but not tauro UDCA levels increased significantly (p less than 0.01); UDCA (7.7 (12.6) v 40.2 (12.7)%) became the major species of the circulating bile acids. Primary bile acids (23 (28.3) v 11.2 (10.5) and their glycoconjugates fell significantly (p less than 0.01). There were no significant changes in the concentrations of conjugates of the secondary bile acids (4.5 (3.8) v 3.9 (3.0]. Our study shows that oral administration of UDCA to patients with primary biliary cirrhosis induced marked changes in the circulating pool of endogenous bile acids together with improvement in liver function test values. The data also suggest that the beneficial effect of longterm administration of UDCA in these patients might be mediated through changes in the circulating primary bile acids and UDCA rather than through changes in the circulating secondary bile acids, deoxycholate and lithocholate.<\/jats:p>","DOI":"10.1136\/gut.30.8.1110","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1110-1115","source":"Crossref","is-referenced-by-count":42,"title":["Bile acid glycine and taurine conjugates in serum of patients with primary biliary cirrhosis: effect of ursodeoxycholic treatment."],"prefix":"10.1136","volume":"30","author":[{"given":"Y","family":"Chretien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Poupon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Gherardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Chazouilleres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Labbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Myara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Trivin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,8,1]]},"reference":[{"key":"ref_1","first-page":"834","article-title":"Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis","volume":"i:","author":"Poupon, R.; Chretien, Y.; Poupon, R.E.; Ballet, F.; Calmus, Y.; Darnis, F.","year":"1987","unstructured":"Poupon R, Chretien Y, Poupon RE, Ballet F, Calmus Y, Darnis F. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis. Lancet 1987; i: 834-6.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hep.1840040416","article-title":"Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties. Studies on isolated hepatocytes and lipid membrane vesicles","volume":"4","author":"Scholmerich, J.; Becher, M.S.; Schmidt, K.","year":"1984","unstructured":"Scholmerich J, Becher MS, Schmidt K, et al. Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties. Studies on isolated hepatocytes and lipid membrane vesicles. 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Dig Dis Sci 1982; 27: 833-56.","journal-title":"Dig Dis Sci"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0378-4347(00)84596-X","article-title":"Extraction and fractionation of bile acids and their conjugates using prepacked microparticulate silica cartridges (Sed-Pak SilR and Bond-ElutRC 18)","volume":"343","author":"Street, J.M.; Trafford, D.J.H.; Makin, H.L.J.","year":"1985","unstructured":"Street JM, Trafford DJH, Makin HLJ. Extraction and fractionation of bile acids and their conjugates using prepacked microparticulate silica cartridges (Sed-Pak SilR and Bond-ElutRC 18). J Chromatogr 1985; 343: 259-70.","journal-title":"J Chromatogr"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0003-2697(83)90301-9","article-title":"Ion-pair extraction of bile acids with Lipidex gel","volume":"134","author":"Dyfverman, A.; Sjovall, J.","year":"1983","unstructured":"Dyfverman A, Sjovall J. Ion-pair extraction of bile acids with Lipidex gel. Anal Biochem 1983; 134: 303-8.","journal-title":"Anal Biochem"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0016-5085(86)90708-0","article-title":"Effect of ursodeoxycholic acid and chenodeoxycholic acid on cholesterol and bile acid metabolism","volume":"91","author":"Tint, G.S.; Salen, G.; Shefer, S.","year":"1986","unstructured":"Tint GS, Salen G, Shefer S. Effect of ursodeoxycholic acid and chenodeoxycholic acid on cholesterol and bile acid metabolism. 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Hepatology 1981; 1: 36.","journal-title":"Hepatology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.30.8.1110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:56:57Z","timestamp":1763747817000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.30.8.1110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8]]},"references-count":16,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1989,8,1]]},"published-print":{"date-parts":[[1989,8]]}},"alternative-id":["10.1136\/gut.30.8.1110"],"URL":"https:\/\/doi.org\/10.1136\/gut.30.8.1110","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,8]]}}}