{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T16:12:31Z","timestamp":1765642351469,"version":"3.48.0"},"reference-count":18,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:p>The purpose of the present study was to compare omeprazole 20 mg once daily and ranitidine 150 mg twice daily in healing duodenal ulcers unhealed by previous treatment with cimetidine greater than or equal to 0.8 g or ranitidine greater than or equal to 0.3 g daily for at least six weeks. In a double blind multicentre trial, 151 patients were randomly assigned to either omeprazole or ranitidine. Clinical assessments and endoscopies were carried out at two and four weeks. Patients characteristics were similar in both groups. Statistical analysis (chi 2 test) did not show any significant difference in healing rate (p greater than 0.20) irrespective of the method of calculation. On an 'intent-to-treat' analysis (n = 151), healing was: omeprazole 46.6%, ranitidine 43.3% at day 15 and omeprazole 70.7%, ranitidine 68.4% at day 29; and among the patients who completed treatment, healing was: omeprazole 48.3%, ranitidine 46.3% at day 15 (n = 125; 95% confidence interval of the difference--17 to 21) and omeprazole 79.6%, ranitidine 75.4% at day 29 (n = 115; 95% confidence interval of the difference--13 to 21). After a further four weeks treatment with omeprazole, healing occurred in 16\/20 (80%) who still had active disease at day 29. Patients on omeprazole and on ranitidine experienced similar decrease in day time and night time epigastric pain and in heartburn. Multivariate analysis (logistic regression) did not indicate any influence on age, sex, smoking and alcohol habits, previous drug administered, duodenitis and duodenal erosions on the healing rate. In this model, healing rate was not significantly influenced by previous treatment duration (p = 0.09 at day 15 and p greater than 0.2 at day 29) but was significantly influenced by ulcer size (p = 0.04 at day 15 and p = 0.02 at day 29). Forty one patients complained of adverse events: 19 on omeprazole (four trial withdrawals), 22 on ranitidine (three trial withdrawals).<\/jats:p>","DOI":"10.1136\/gut.30.9.1173","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1173-1178","source":"Crossref","is-referenced-by-count":30,"title":["Double blind multicentre comparison of omeprazole 20 mg once daily versus ranitidine 150 mg twice daily in the treatment of cimetidine or ranitidine resistant duodenal ulcers."],"prefix":"10.1136","volume":"30","author":[{"given":"J C","family":"Delchier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Isal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Soule","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1136\/bmj.289.6452.1095","article-title":"Duodenal ulcers which do not hcal rapidl]","volume":"289","author":"Wormslev, K.G.","year":"1984","unstructured":"Wormslev KG. Duodenal ulcers which do not hcal rapidl]. Br MedJ 1984; 289: 1095.","journal-title":"Br MedJ"},{"key":"ref_2","first-page":"32","article-title":"ct al. Omepriazole heals duodenal. but not gastric ulcers morc rapidly than ranitidine. Results of two German multicenter trials","volume":"1985","author":"W, C.(lasseni M.Damman H.G.Domschkc","unstructured":"C(lasseni M. Damman HG. Domschkc W. ct al. Omepriazole heals duodenal. but not gastric ulcers morc rapidly than ranitidine. Results of two German multicenter trials. Hepatogastroenteirolog 1985: 32: 243-5.","journal-title":"Hepatogastroenteirolog"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/00004836-198608000-00005","article-title":"A comparison of two differcnt doses of omeprazole versus ranitidine in treatment of duodenal ulcers","volume":"8","author":"K, Bardhan K.D.Bianchi-Porro G.Bose","year":"1986","unstructured":"Bardhan KD. Bianchi-Porro G. Bose K. et al. A comparison of two differcnt doses of omeprazole versus ranitidine in treatment of duodenal ulcers. J Clin (iastroenterol 1986: 8: 408-13.","journal-title":"J Clin (iastroenterol"},{"key":"ref_4","first-page":"753","article-title":"Efficacitc comparec de l'omeprazolc et de la cim6tidine dans Ic traitemcnt de lulccre duod6nal en poussec 6volutivc. Essai th6rapeutique contr6ol multicentrique francais","volume":"11","author":"JP, Bigard M.A.Isal J.P.Galmichc J.P.Ebrard F.Bader","year":"1987","unstructured":"Bigard MA. Isal JP. Galmichc JP. Ebrard F. Bader JP. Efficacitc comparec de l'omeprazolc et de la cim6tidine dans Ic traitemcnt de lulccre duod6nal en poussec 6volutivc. Essai th6rapeutique contr6ol multicentrique francais. Gastioenterol Clin Biol 1987; 11: 753-7.","journal-title":"Gastioenterol Clin Biol"},{"key":"ref_5","first-page":"1130","article-title":"mg daily) vcrsus cimetidine (1200 mg daily) in duodenal ulcer hcaling","author":"RJ, Archambault A.P.Pare P.Bailey","year":"(2t)","unstructured":"Archambault AP. Pare P. Bailey RJ. et al. Omeprazole (2t) mg daily) vcrsus cimetidine (1200 mg daily) in duodenal ulcer hcaling and pain rclief. Gastroenterology 1986; 94: 1130-4.","journal-title":"et al. Omeprazole; and pain rclief. Gastroenterology 1986; 94"},{"issue":"289","key":"ref_6","first-page":"525","article-title":"Omeprazole in duodenal ulceration: acid inhibition. symptom relief. endoscopic hcaling. and recurrence","volume":"1984","author":"IF, Meyric-Thomas J.Misiewicz J.J.Trotman","unstructured":"Meyric-Thomas J. Misiewicz JJ. Trotman IF. et al. Omeprazole in duodenal ulceration: acid inhibition. symptom relief. endoscopic hcaling. and recurrence. Br MedJ 1984: 289: 525-8.","journal-title":"Br MedJ"},{"key":"ref_7","first-page":"254","article-title":"Ranitidinc in the treatment of cimetidinc rcsistant ulcerations of the upper intcstinal tract","volume-title":"clinical use o)f rainitidine","author":"U, Brunncr G.Losgen H.Harke","year":"1982","unstructured":"Brunncr G. Losgen H. Harke U. Ranitidinc in the treatment of cimetidinc rcsistant ulcerations of the upper intcstinal tract. In: Misiewicz JJ. Wormslcy KG. eds. Tue clinical use o)f rainitidine. Oxford: Medicine Publishing Foundation. 1982: 254-6."},{"issue":"25","key":"ref_8","first-page":"1113","article-title":"Trcatment of Icimetidinc resistant chronic duodenal ulcers with ranitidinc or cimetidinc: a randomiscd multicentre study","volume":"1984","author":"PA, Quatrini M.Basilisco G.Bianchi","unstructured":"Quatrini M. Basilisco G. Bianchi PA. Trcatment of Icimetidinc resistant chronic duodenal ulcers with ranitidinc or cimetidinc: a randomiscd multicentre study. 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Gut 1987; 28: 907-11. 1i2 Walt RP, Malc PJ, Rawlings J, Hunt RH, MiltonThompson GJ, Misiewicz JJ. Comparison of the cffccts of ranitidine, cimetidine and placebo on the 24 hour intragastric acidity and nocturnal acid secrction in patients with duodenal ulcer. Cut 1982; 22: 49-54.","journal-title":"Tripotassium dicitrato bismuthate (TDB) vcrsus two diffcrcnt dosages of cimetidinc in the trcatmcnt of rcsistant duodenal ulccrs; Gut"},{"key":"ref_10","first-page":"352","article-title":"Effet dc la ranitidine sur Ic pH gastrique chez Ic sujet sain. Intrct de 1'enregistremcnt continu sur 24 Heures pour Ic choix du fractionnemcrnt optimal d'unc dosc th6rapcutiquc. (Gastioenterot Chin Riol","volume":"6","author":"Galmiche, J.P.; Vallot, T.; Maycur, S.","year":"1982","unstructured":"Galmiche JP, Vallot T, Maycur S, et al. Effet dc la ranitidine sur Ic pH gastrique chez Ic sujet sain. Intrct de 1'enregistremcnt continu sur 24 Heures pour Ic choix du fractionnemcrnt optimal d'unc dosc th6rapcutiquc. (Gastioenterot Chin Riol 1982; 6: 352-9."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/bmj.287.6384.12","article-title":"Effcct of daily oral omeprazolc on 24 hour intragastric acidity","volume":"287","author":"Walt, R.P.; de FA, Gomes M.; Wood, E.C.; Pounder, Logan L.H.; R.E.","year":"1983","unstructured":"Walt RP, Gomes M de FA, Wood EC, Logan LH. Pounder RE. Effcct of daily oral omeprazolc on 24 hour intragastric acidity. Br MedJ 1983; 287: 12-4.","journal-title":"Br MedJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1080\/00365521.1984.12005832","article-title":"Effcct of omcprazolc, a substituted benzimidazole, on 24-H intragastric acidity in paticnts with pcptic ulcer diseasc","volume":"19","author":"Naesdal, J.; Bodemar, G.; Walan, A.","year":"1984","unstructured":"Naesdal J, Bodemar G, Walan A. Effcct of omcprazolc, a substituted benzimidazole, on 24-H intragastric acidity in paticnts with pcptic ulcer diseasc. Scand J Castroeniterol 1984; 19: 916-22.","journal-title":"Scand J Castroeniterol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/gut.25.9.957","article-title":"Optimal dose of oral omeprazolc for maximal 24 hour decrease of intragastric acidity","volume":"25","author":"Sharma, B.K.; Walt, R.P.; Pounder, R.E.; dc FA, Gomcs M.; Wood, E.C.; Logan, L.H.","year":"1984","unstructured":"Sharma BK, Walt RP, Pounder RE, Gomcs M dc FA, Wood EC, Logan LH. Optimal dose of oral omeprazolc for maximal 24 hour decrease of intragastric acidity. Gut 1984; 25: 957-64.","journal-title":"Gut"},{"key":"ref_14","first-page":"148","article-title":"Low-dosc omeprazolc effects on gastric acid secretion in normal man","volume":"11","author":"JP, Hcmery P.Galmiche; C, Rozc","year":"1987","unstructured":"Hcmery P. Galmiche JP, Rozc C, et al. Low-dosc omeprazolc effects on gastric acid secretion in normal man. Gastiroenterol Clin Biol 1987; 11: 148-53.","journal-title":"Gastiroenterol Clin Biol"},{"key":"ref_15","first-page":"239","article-title":"Twenty four-hour intragastric acidity and plasma gastrin conccntration before and during treatment with cither ranitidinc or omeprazole","volume":"1","author":"RE, Lanzon-Millcr S.Poundcr; MR, Hamilton; etcial","year":"1987","unstructured":"Lanzon-Millcr S. Poundcr RE, Hamilton MR, etcial. Twenty four-hour intragastric acidity and plasma gastrin conccntration before and during treatment with cither ranitidinc or omeprazole. 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Gut 1984; 25: 1211-6.","journal-title":"Gut"},{"key":"ref_17","first-page":"583","article-title":"L'enregistrement nocturne du pH gastriquc permet-il dc prevoir la r6ponsc th6rapeutique des ulccrcs duod6naux sv&ces trait6s par ranitidine'?","volume":"9","author":"Galmichc, J.P.; Tranvouez, J.L.; Denis, P.; etcil","year":"1985","unstructured":"Galmichc JP, Tranvouez JL, Denis P,etcil. L'enregistrement nocturne du pH gastriquc permet-il dc prevoir la r6ponsc th6rapeutique des ulccrcs duod6naux sv&ces trait6s par ranitidine'? Gastroenterol Clin Riol 1985; 9: 583-9.","journal-title":"Gastroenterol Clin Riol"},{"key":"ref_18","first-page":"31","article-title":"Omeprazole in pcptic ulcers rcsistant to histamine H2-receptor antagonists","volume":"1","author":"Tytgat, G.N.J.; Lamers, C.B.H.W.; Hammceteman, W.; Wilson, Jansen J.M.B.J.I.; J.A.","year":"1987","unstructured":"Tytgat GNJ, Lamers CBHW, Hammceteman W, Jansen JMBJI Wilson JA. Omeprazole in pcptic ulcers rcsistant to histamine H2-receptor antagonists. Alimnent Phartnacol Thlerap 1987; 1: 31-8.","journal-title":"Alimnent Phartnacol Thlerap"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.30.9.1173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T16:09:33Z","timestamp":1765642173000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.30.9.1173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9]]},"references-count":18,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1989,9,1]]},"published-print":{"date-parts":[[1989,9]]}},"alternative-id":["10.1136\/gut.30.9.1173"],"URL":"https:\/\/doi.org\/10.1136\/gut.30.9.1173","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1989,9]]}}}