{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T09:54:25Z","timestamp":1765619665168,"version":"3.48.0"},"reference-count":33,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:p>Dysphagia is a frequent cause of referral for oesophageal manometry although the motor response to eating is not routinely studied. We examined symptoms and oesophageal motor patterns in response to eating bread in 30 patients with either gastro-oesophageal reflux (n = 20), or normal oesophageal function tests (n = 10). No patient experienced symptoms while swallowing water but one complained of heartburn and one developed symptomatic oesophageal 'spasm' during eating. In eight further patients, pain or dysphagia which occurred with swallowing bread was associated with aperistalsis. Comparing asymptomatic and symptomatic periods, there was a slight increase in mean swallow frequency from 7.5 (0.79) (SEM) to 9.0 (1.17) swallows per minute (NS; n = 10). The mean number of aperistalsis swallows increased from 4.5 (0.96) per minute to 6.2 (1.30) (p less than 0.01; n = 10). Aperistalsis during symptoms was mainly caused by non-conducted swallows rather than synchronous contractions (mean 5.8 (1.45) per minute compared with 1.2 (0.44]. Aperistalsis can be produced by rapid swallowing in the normal oesophagus through 'deglutitive inhibition'. These results suggest that some patients experience dysphagia associated with aperistalsis perhaps as a response to increased frequency of swallowing. Functional abnormalities of this nature will not be detected by conventional oesophageal manometry.<\/jats:p>","DOI":"10.1136\/gut.30.9.1179","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1179-1186","source":"Crossref","is-referenced-by-count":23,"title":["Oesophageal manometry during eating in the investigation of patients with chest pain or dysphagia."],"prefix":"10.1136","volume":"30","author":[{"given":"P J","family":"Howard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pryde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C","family":"Heading","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,9,1]]},"reference":[{"key":"ref_1","first-page":"1143","article-title":"The oesophagus as a cause of recurrent chest pain: which patients should be investigated and which tests should be used?","volume":"ii:","author":"JS, I.De Caestecker; JN, Blackwell; J, Brown; RC, Heading","year":"1985","unstructured":"I De Caestecker JS, Blackwell JN, Brown J, Heading RC. The oesophagus as a cause of recurrent chest pain: which patients should be investigated and which tests should be used? Lancet 1985; ii: 1143-6.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/BF01072186","article-title":"Pope 11 CE. Esophageal manometries in patients with angina-like chest pain","volume":"2","author":"Brand, D.L.; Martin, D.","year":"1977","unstructured":"Brand DL, Martin D, Pope 11 CE. Esophageal manometries in patients with angina-like chest pain. Dig Dis Sci 1977; 2: 300-4.","journal-title":"Dig Dis Sci"},{"key":"ref_3","first-page":"191","article-title":"Angina and oesophageal disease","volume":"i:","author":"Anonymous","year":"1986","unstructured":"Anonymous. Angina and oesophageal disease [Editorial]. Lancet 1986; i: 191-2.","journal-title":"Lancet"},{"key":"ref_4","first-page":"395","article-title":"Manometric findings during spontaneous chest pain in patients with presumed esophageal 'spasms'","volume-title":"Gastroenterology 1983; 85","author":"Clouse, R.E.; Staiano, A.; Landau, D.W.; Schlachter, J.L.","unstructured":"Clouse RE, Staiano A, Landau DW, Schlachter JL. Manometric findings during spontaneous chest pain in patients with presumed esophageal 'spasms'. Gastroenterology 1983; 85: 395-402."},{"key":"ref_5","first-page":"2","article-title":"Human oesophageal response during chest pain induced by swallowing cold liquids","volume":"246","author":"Meyer, G.W.; Castell, D.O.","year":"1981","unstructured":"Meyer GW, Castell DO. Human oesophageal response during chest pain induced by swallowing cold liquids. 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Gastroenterology 1983; 84: 893-901."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.7326\/0003-4819-103-1-14","article-title":"Edrophonium: a useful provocative test for esophageal chest pain","volume":"103","author":"Richter, J.E.; Hackshaw, B.T.; Wu, W.S.; Castell, D.O.","year":"1985","unstructured":"Richter JE, Hackshaw BT, Wu WS, Castell DO. Edrophonium: a useful provocative test for esophageal chest pain. Ann Intern Med 1985; 103: 14-21.","journal-title":"Ann Intern Med"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1136\/gut.29.8.1029","article-title":"Comparison of iv edrophonium and esophageal acid perfusion during oesophageal manometry in patients with non-cardiac chest pain","volume":"29","author":"JS, De Caestecker; A, Pryde; RC, Heading","year":"1988","unstructured":"De Caestecker JS, Pryde A, Heading RC. 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Am J Phlysiol 1981; 241: G 129-36.","journal-title":"Am J Phlysiol; cds. Diseases of the esophlagus"},{"key":"ref_28","first-page":"485","article-title":"Effect of timc interval between swallows on esophageal peristalsis","volume":"238","author":"L, Ask P.Tibbling","year":"1980","unstructured":"Ask P. Tibbling L. Effect of timc interval between swallows on esophageal peristalsis. Am J Phlysiol 1980; 238: G485-90.","journal-title":"Am J Phlysiol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0016-5085(86)90685-2","article-title":"Abnormal sensory perception in patients with csophageal chcst pain","volume":"91","author":"Richter, J.E.; Castell, Barish C.F.; D.O.","year":"1986","unstructured":"Richter JE, Barish CF. Castell DO. Abnormal sensory perception in patients with csophageal chcst pain. Gastroenterology 1986; 91: 845-52.","journal-title":"Gastroenterology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/gut.28.3.272","article-title":"Motor responses of the oesophagus to intraluminal distension in normal subjects and patients with oesophageal clearance disorders","volume":"28","author":"Kendall, G.P.N.; Thompson, D.G.; Day, S.J.; Garvic, N.","year":"1987","unstructured":"Kendall GPN, Thompson DG, Day SJ, Garvic N. Motor responses of the oesophagus to intraluminal distension in normal subjects and patients with oesophageal clearance disorders. Gut 1987; 28: 272-9.","journal-title":"Gut"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3109\/00365528509088851","article-title":"Oesophageal motility during acid-provoked heartburn and chest pain","volume":"20","author":"Kjellen, G.; Tibbling, L.","year":"1985","unstructured":"Kjellen G, Tibbling L. Oesophageal motility during acid-provoked heartburn and chest pain. Scand J Gastroenterol 1985; 20: 937-40.","journal-title":"Scand J Gastroenterol"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1172\/JCI104760","article-title":"Esophageal motor abnormalities induced by acid perfusion in patients with hcartburn","volume":"42","author":"Cl, Siegel; TR, Hendrix","year":"1963","unstructured":"Siegel Cl, Hendrix TR. Esophageal motor abnormalities induced by acid perfusion in patients with hcartburn. J Clin Invest 1963; 42: 686-95.","journal-title":"J Clin Invest"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/BF02233010","article-title":"Relationship between motor changes and pain during csophageal acid perfusion","volume":"13","author":"Atkinson, M.; Bennett, JR","year":"1968","unstructured":"Atkinson M, Bennett JR. Relationship between motor changes and pain during csophageal acid perfusion. Am J Dig Dis 1968; 13: 346-50.","journal-title":"Am J Dig Dis"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.30.9.1179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T09:51:23Z","timestamp":1765619483000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.30.9.1179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1989,9,1]]},"published-print":{"date-parts":[[1989,9]]}},"alternative-id":["10.1136\/gut.30.9.1179"],"URL":"https:\/\/doi.org\/10.1136\/gut.30.9.1179","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1989,9]]}}}