{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:59:25Z","timestamp":1765666765313,"version":"3.45.0"},"reference-count":20,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p>Introduction of a radioactive gastrointestinal marker (51CrCl3) into a combined study (75SeHCAT + 58CoB12) of ileal function by whole body counting has been undertaken. The technique was assessed in 23 subjects (15 patients with inflammatory bowel disease, six on non-steroidal anti-inflammatory drugs for rheumatoid arthritis, and two normal subjects). Mean (SD) 51CrCl3 retention was only 4.1 (6.0)% on day 4, and was similar on day 7 in subjects given a second dose of 51CrCl3 on day 4. Only one subject had more than 20% of 51CrCl3 retention after four days. A 51CrCl3 correction method adequately corrected for colonic hold up of 58CoB12, when compared with final equilibrium values of 58CoB12 retention. Use of the non-absorbed 58CoB12 fraction as a gastrointestinal marker gave good agreement with the 51CrCl3 method in correcting 75SeHCAT values. In all subjects studied, corrections for colonic retention of 75SeHCAT on day 4, were small (less than 7% of dose) and did not affect the assessment of any subject. In conclusion, an additional gastrointestinal marker such as 51CrCl3 is unnecessary in our combined study since that role can be effected, when indicated by the non-absorbed 58CoB12 fraction.<\/jats:p>","DOI":"10.1136\/gut.31.10.1120","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1120-1125","source":"Crossref","is-referenced-by-count":6,"title":["Experience with a gastrointestinal marker (51CrCl3) in a combined study of ileal function using 75SeHCAT and 58CoB12 measured by whole body counting."],"prefix":"10.1136","volume":"31","author":[{"given":"T","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Bjarnason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,10,1]]},"reference":[{"key":"ref_1","first-page":"126","article-title":"Enterohepatic circulation in man of a gamma-emitting bile acid conjugate, 23-selena-25-homotaurocholic acid (SeHCAT)","volume":"23","author":"Merrick, M.V.; Eastwood, M.A.; Anderson, JR, Ross; H.M.","year":"1982","unstructured":"Merrick MV, Eastwood MA, Anderson JR, Ross HM. Enterohepatic circulation in man of a gamma-emitting bile acid conjugate, 23-selena-25-homotaurocholic acid (SeHCAT). J Nucl Med 1982; 23: 126-30.","journal-title":"J Nucl Med"},{"key":"ref_2","first-page":"6","article-title":"Behaviour of the gamma labelled bile acid 7SeHCAT in the enterohepatic circulation in man","volume-title":"New radioisotope tests in gastroenterology. Proc 2nd International Symposium","author":"Northfield, T.C.; Jazrawi, R.P.; Galatola, G.","year":"1986","unstructured":"Northfield TC, Jazrawi RP, Galatola G. Behaviour of the gamma labelled bile acid 7SeHCAT in the enterohepatic circulation in man. In: Malaguti P, Sciaretta G, Abbati A, Furno A, eds. New radioisotope tests in gastroenterology. Proc 2nd International Symposium. (Bologna, Oct 24-25, 1986). 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Gastroenterology 1983; 84: 63-8."},{"key":"ref_5","first-page":"1131","article-title":"The mechanism of diarrhoea resulting from pelvic and abdominal radiotherapy; a prospective study using selenium-75 labelled conjugated bile acid and cobalt-58 labelled cyanocobalamin","volume":"57","author":"Yeoh, E.K.; Lui, D.; Lee, N.Y.","year":"1984","unstructured":"Yeoh EK, Lui D, Lee NY. The mechanism of diarrhoea resulting from pelvic and abdominal radiotherapy; a prospective study using selenium-75 labelled conjugated bile acid and cobalt-58 labelled cyanocobalamin. Br 7 Radiol 1984; 57: 1131-6."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0009-9260(85)80059-3","article-title":"The pathogenesis of postirradiation chronic diarrhoea: measurement of SeHCAT and B12 absorption for differential diagnosis determines treatment","volume":"36","author":"Ludgate, S.M.; Merrick, M.V.","year":"1985","unstructured":"Ludgate SM, Merrick MV. 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Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans. Gastroenterology 1987; 93: 480-9.","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00251479","article-title":"New method for the determination of bile acid turnover using 'Se-homocholic acid taurine","volume":"7","author":"Delhez, H.; Van den Berg, J.W.O.; Van Blankenstein, M.; Meerwaldt, J.H.","year":"1982","unstructured":"Delhez H, Van den Berg JWO, Van Blankenstein M, Meerwaldt JH. New method for the determination of bile acid turnover using 'Se-homocholic acid taurine. EurJ Nucl Med 1982; 7: 269-71.","journal-title":"EurJ Nucl Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000198883","article-title":"SeHCAT absorption: a simple test of ileal dysfunction","volume":"26","author":"Fagan, E.A.; Chadwick, U.S.; McLean Baird, I.","year":"1983","unstructured":"Fagan EA, Chadwick US, McLean Baird I. SeHCAT absorption: a simple test of ileal dysfunction. Digestion 1983; 26: 159-65.","journal-title":"Digestion"},{"key":"ref_11","first-page":"581","article-title":"A comparison between the use of a shadow shield whole body counter and an uncollimated gamma camera in the assessment of the seven-day retention of SeHCAT","volume":"57","author":"Hames, T.K.; Condon, B.R.; Fleming, J.S.","year":"1984","unstructured":"Hames TK, Condon BR, Fleming JS, et al. A comparison between the use of a shadow shield whole body counter and an uncollimated gamma camera in the assessment of the seven-day retention of SeHCAT. Br 7 Radiol 1984; 57: 581-4."},{"key":"ref_12","first-page":"455","article-title":"Tests for the absorption of 7SSe-labelled homocholic acid conjugated with taurine (71Se-HCAT)","volume":"10","author":"Schroth, H.J.; Berberich, R.; Feifel, G.; Muller, K.P.; Ecker, K.W.","year":"1985","unstructured":"Schroth HJ, Berberich R, Feifel G, Muller KP, Ecker KW. 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