{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:49:42Z","timestamp":1770756582786,"version":"3.50.0"},"reference-count":26,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:p>Twenty four hour oesophageal intraluminal pH probe studies were performed in 114 children (range age: one month-12 years) referred for symptoms or signs compatible with gastroesophageal reflux. Forty five patients had reflux disease alone, 69 had evidence of oesophagitis which was assessed endoscopically and histologically. Recordings were also performed in 63 control patients. The occurrence of reflux was analysed for the total study period and particularly while awake, asleep, fasting, and during postcibal periods. Oesophageal acid exposure time and the number of reflux episodes lasting greater than five minutes during the total study period provided the best discrimination between patients and controls; however, 20% and 30% of all reflux patients had both normal (with 2 SD of control) acid exposure time and number of long lasting reflux episodes, respectively. Patients with oesophagitis had significantly more acid reflux than those with simple uncomplicated disease during postcibal, fasting, awake periods, but not during sleep; however, increasing severity of oesophagitis was not associated with increasing acid exposure. The ability of the intraluminal oesophageal pH test to discriminate patients with various degrees of reflux disease decreased if only postprandial pH variables were taken into account. We conclude that: (1) the 24 hour intraoesophageal pH monitoring may present false negative results that limit overall sensitivity of the test; (2) the presence of oesophagitis does not seem to be associated with increased oesophageal acid exposure during sleep; (3) limiting the pH recording to postprandial periods reduces the discriminatory power of the test.<\/jats:p>","DOI":"10.1136\/gut.31.2.129","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"129-133","source":"Crossref","is-referenced-by-count":51,"title":["Value of the 24 hour intraoesophageal pH monitoring in children."],"prefix":"10.1136","volume":"31","author":[{"given":"S","family":"Cucchiara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Staiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Gobio Casali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Boccieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F M","family":"Paone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-5223(19)37879-1","article-title":"Technique, indications, and clinical use of 24 hour oesophageal pH monitoring","volume":"79","author":"TR, De Meester; CI, Wang; JA, Wernly; CA, Pellegrini; AG, Little; P, Klementschitsch; G, Bermudez; LF, Johnson; DB, Skinner","year":"1980","unstructured":"De Meester TR, Wang CI, Wernly JA, Pellegrini CA, Little AG, Klementschitsch P, Bermudez G, Johnson LF, Skinner DB. Technique, indications, and clinical use of 24 hour oesophageal pH monitoring. J Thorac Cardiovasc Surg 1980; 79: 656-70.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0016-5085(81)90065-2","article-title":"Twenty-four-hour oesophageal intraluminal pH probe testing: a comparative analysis","volume":"80","author":"Euler, A.R.; Byrne, W.J.","year":"1981","unstructured":"Euler AR, Byrne WJ. Twenty-four-hour oesophageal intraluminal pH probe testing: a comparative analysis. Gastroenterology 1981; 80: 957-61.","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00000658-197610000-00009","article-title":"Patterns of gastro-oesophageal reflux in health and disease","volume":"184","author":"TR, De Meester; LF, Johnson; GJ, Joseph; M, Toscano; AW, Hall; DB, Skinner","year":"1976","unstructured":"De Meester TR, Johnson LF, Joseph GJ, Toscano M, Hall AW, Skinner DB. Patterns of gastro-oesophageal reflux in health and disease. Ann Surg 1976; 184: 459-70.","journal-title":"Ann Surg"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0022-3468(81)80012-7","article-title":"Postcibal gastro-oesophageal reflux in children","volume":"16","author":"Jolley, S.G.; Herbst, J.J.; Johnson, D.G.; Matlak, M.E.; Book, L.S.; Pena, A.","year":"1981","unstructured":"Jolley SG, Herbst JJ, Johnson DG, Matlak ME, Book LS, Pena A. Postcibal gastro-oesophageal reflux in children. J Pediatr Surg 1981; 16: 487-90.","journal-title":"J Pediatr Surg"},{"key":"ref_5","first-page":"1501","article-title":"Esophageal pH monitoring during sleep identifies children with respiratory symptoms","volume-title":"from gastro-oesophageal reflux. Gastroenterology 1981; 80","author":"Jolley, S.G.; Herbst, J.J.; Johnson, D.G.; Matlak, M.E.; Book, L.S.","unstructured":"Jolley SG, Herbst JJ, Johnson DG, Matlak ME, Book LS. Esophageal pH monitoring during sleep identifies children with respiratory symptoms from gastro-oesophageal reflux. Gastroenterology 1981; 80: 1501-6."},{"key":"ref_6","article-title":"Intraoesophageal pH monitoring as a discriminator","volume-title":"of oesophagitis in children. Gastroenterology 1984; 86: 1025","author":"Berquist, W.; Akhanjee, N.; Youkales, L.; Ament, M.","unstructured":"Berquist W, Akhanjee N, Youkales L, Ament M. Intraoesophageal pH monitoring as a discriminator of oesophagitis in children. Gastroenterology 1984; 86: 1025."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00005176-198801000-00010","article-title":"Simultaneous pH recordings from multiple oesophageal sites in children with and without distal gastro-oesophageal reflux","volume":"7","author":"Sondheimer, J.M.; Haase, G.M.","year":"1988","unstructured":"Sondheimer JM, Haase GM. Simultaneous pH recordings from multiple oesophageal sites in children with and without distal gastro-oesophageal reflux. J Pediatr Gastroenterol Nutr 1988; 7:46-51.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref_8","first-page":"81","article-title":"Correlation of oesophageal lengths in children with height: application to the Tuttle test without prior oesophageal manometry","volume":"94","author":"Strobel, C.T.; Byrne, W.J.; Ament, M.E.; Euler, A.R.","year":"1979","unstructured":"Strobel CT, Byrne WJ, Ament ME, Euler AR. Correlation of oesophageal lengths in children with height: application to the Tuttle test without prior oesophageal manometry. J7Pediatr 1979; 94: 81-4."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0022-3476(86)80925-8","article-title":"Esophageal motor abnormalities in children with gastro-oesophageal reflux and peptic oesophagitis","volume":"108","author":"Cucchiara, S.; Staiano, A.; Di Lorenzo, C.","year":"1986","unstructured":"Cucchiara S, Staiano A, Di Lorenzo C, et al. Esophageal motor abnormalities in children with gastro-oesophageal reflux and peptic oesophagitis. J Pediatr 1986; 108: 907-10.","journal-title":"J Pediatr"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0022-3476(85)80180-3","article-title":"Esophagitis: a frequent consequence of gastrooesophageal reflux in infancy","volume":"107","author":"Shub, M.D.; Ulshen, M.H.; Hargrove, C.B.; Siegal, G.P.; Groben, P.A.; Askin, F.B.","year":"1985","unstructured":"Shub MD, Ulshen MH, Hargrove CB, Siegal GP, Groben PA, Askin FB. Esophagitis: a frequent consequence of gastrooesophageal reflux in infancy. J Pediatr 1985; 107: 881-4.","journal-title":"J Pediatr"},{"key":"ref_11","first-page":"447","article-title":"Duodenogastric reflux and reflux oesophagitis","volume":"%:","author":"Little, A.G.; Martinez, E.L.; De Meester, T.R.; Blough, R.M.; Skinner, D.B.","year":"1984","unstructured":"Little AG, Martinez EL, De Meester TR, Blough RM, Skinner DB. Duodenogastric reflux and reflux oesophagitis. Surgery 1984; %: 447-54.","journal-title":"Surgery"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1136\/gut.26.5.495","article-title":"Bile acid concentrations in the gastric juice of patients with erosive oesophagitis","volume":"26","author":"Collins, B.J.; Crothers, G.; McFarland, R.J.; Love, A.H.G.","year":"1985","unstructured":"Collins BJ, Crothers G, McFarland RJ, Love AHG. Bile acid concentrations in the gastric juice of patients with erosive oesophagitis. Gut 1985; 26: 495-9.","journal-title":"Gut"},{"key":"ref_13","first-page":"371","article-title":"Do bile acids reflux into the oesophagus? A study in normal subjects and patients with gastro-oesophageal reflux disease","volume":"92","author":"Mittal, R.K.; Reuben, A.; Whithey, J.O.; McCallum, R.W.","year":"1987","unstructured":"Mittal RK, Reuben A, Whithey JO, McCallum RW. Do bile acids reflux into the oesophagus? A study in normal subjects and patients with gastro-oesophageal reflux disease. Gastroenterology 1987; 92: 371-5.","journal-title":"Gastroenterology"},{"key":"ref_14","first-page":"69","article-title":"Acid neutralizating capacity","volume-title":"of human saliva. Gastroenterology 1982; 83","author":"Helm, J.F.; Dodds, W.J.; Hogan, W.J.; Soergel, K.H.; Egide, M.S.; Wood, C.M.","unstructured":"Helm JF, Dodds WJ, Hogan WJ, Soergel KH, Egide MS, Wood CM. Acid neutralizating capacity of human saliva. Gastroenterology 1982; 83: 69-74."},{"key":"ref_15","first-page":"175","article-title":"Is 24-hr ooesophageal pH-metry a reproducible test?","volume":"17","author":"Bontempo, I.; Corazziari, E.; Tosoni, M.; Ercole, A.; Torsoli, A.","year":"1985","unstructured":"Bontempo I, Corazziari E, Tosoni M, Ercole A, Torsoli A. Is 24-hr ooesophageal pH-metry a reproducible test? Ital J Gastroenterol 1985; 17: 175.","journal-title":"Ital J Gastroenterol"},{"key":"ref_16","first-page":"946","article-title":"Patterns of postcibal gastro-oesophageal reflux in symptomatic infants. AmJ'","volume":"138","author":"Jolley, S.G.; Herbst, J.J.; Johnson, D.G.; Book, L.S.; Matlak, M.E.; Condon, V.R.","year":"1979","unstructured":"Jolley SG, Herbst JJ, Johnson DG, Book LS, Matlak ME, Condon VR. Patterns of postcibal gastro-oesophageal reflux in symptomatic infants. AmJ' Surg 1979; 138: 946-50.","journal-title":"Surg"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0022-3476(80)80546-4","article-title":"Continuous monitoring of distal oesophageal pH: a diagnostic test for gastro-oesophageal reflux in infants","volume":"96","author":"Sondheimer, J.M.","year":"1980","unstructured":"Sondheimer JM. Continuous monitoring of distal oesophageal pH: a diagnostic test for gastro-oesophageal reflux in infants. J Pediatr 1980; 96: 804-7.","journal-title":"J Pediatr"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF01313584","article-title":"Acid clearance during sleep in the pathogenesis of reflux oesophagitis","volume":"26","author":"Orr, W.C.; Robinson, M.G.; Johnson, F.","year":"1981","unstructured":"Orr WC, Robinson MG, Johnson F. Acid clearance during sleep in the pathogenesis of reflux oesophagitis. Dig Dis Sci 1981; 26: 423-7.","journal-title":"Dig Dis Sci"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1136\/gut.28.5.519","article-title":"Daytime gastro-oesophageal reflux is important in ooesophagitis","volume":"28","author":"JS, De Caestecker; JN, Blackwell; A, Pryde; RC, Heading","year":"1987","unstructured":"De Caestecker JS, Blackwell JN, Pryde A, Heading RC. Daytime gastro-oesophageal reflux is important in ooesophagitis. Gut 1987; 28: 519-26.","journal-title":"Gut"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1136\/gut.23.11.992","article-title":"Ambulatory monitoring of ooesophageal pH in reflux ooesophagitis using a portable radiotelemetry svstem","volume":"23","author":"Branicki, F.J.; Evans, D.F.; Ogilvie, A.L.; Atkinson, M.; Hardcastle, J.D.","year":"1982","unstructured":"Branicki FJ, Evans DF, Ogilvie AL, Atkinson M, Hardcastle JD. Ambulatory monitoring of ooesophageal pH in reflux ooesophagitis using a portable radiotelemetry svstem. Gut 1982; 23: 992-8.","journal-title":"Gut"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0016-5085(24)05128-X","article-title":"Effect of sleep on swallowing, oesophageal peristalsis and acid clearance","volume":"86","author":"Orr, W.C.; Johnson, L.F.; Robinson, M.G.","year":"1984","unstructured":"Orr WC, Johnson LF, Robinson MG. Effect of sleep on swallowing, oesophageal peristalsis and acid clearance. Gastroenterology 1984; 86: 814-9.","journal-title":"Gastroenterology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0016-5085(81)80072-8","article-title":"Pathogenesis of reflux oesophagitis","volume":"81","author":"Dodds, W.J.; Hogan, W.J.; Helm, J.F.; Dent, J.","year":"1981","unstructured":"Dodds WJ, Hogan WJ, Helm JF, Dent J. Pathogenesis of reflux oesophagitis. Gastroenterologv 1981; 81: 376-94.","journal-title":"Gastroenterologv"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/BF01320487","article-title":"Modified acid reflux test. A benefit and cost analvsis","volume":"30","author":"Cummings, D.R.; Meshkinpour, H.","year":"1985","unstructured":"Cummings DR, Meshkinpour H. Modified acid reflux test. A benefit and cost analvsis. Dig Dis Sci 1985; 30: 739-41.","journal-title":"Dig Dis Sci"},{"key":"ref_24","first-page":"625","article-title":"Diagnostic accuracy of a 3-hr continuous intraluminal pH monitoring of the lower oesophagus in the evaluation of gastro-oesophageal reflux in infancy","volume":"17","author":"Reves, H.M.; Ostrovskv, E.; Radhakrishnan, J.","year":"1982","unstructured":"Reves HM, Ostrovskv E, Radhakrishnan J. Diagnostic accuracy of a 3-hr continuous intraluminal pH monitoring of the lower oesophagus in the evaluation of gastro-oesophageal reflux in infancy. ]7 Pediatr Surg 1982; 17: 625-3 1."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/gut.28.9.1145","article-title":"Ambulatorv 24 hour intraoesophageal pH monitoring in the diagnosis of gastrooesophageal reflux disease","volume":"28","author":"Johnson, F.; Ioalsson, B.; Isberg, P.E.","year":"1987","unstructured":"Johnson F, Ioalsson B, Isberg PE. Ambulatorv 24 hour intraoesophageal pH monitoring in the diagnosis of gastrooesophageal reflux disease. Gut 1987; 28: 1145-50.","journal-title":"Gut"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/gut.18.9.709","article-title":"Postprandial gastro-oesophageal reflux in healthv people","volume":"18","author":"Kave, MD","year":"1977","unstructured":"Kave MD. Postprandial gastro-oesophageal reflux in healthv people. Gut 1977; 18: 709-12.","journal-title":"Gut"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.31.2.129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T19:35:42Z","timestamp":1763753742000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.31.2.129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1990,2,1]]},"published-print":{"date-parts":[[1990,2]]}},"alternative-id":["10.1136\/gut.31.2.129"],"URL":"https:\/\/doi.org\/10.1136\/gut.31.2.129","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}