{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:54:03Z","timestamp":1761310443815,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:p>The aim of our study was to investigate the relationship between gastrin producing cell density with antral mucosa, luminal and serum gastrin concentration in antral atrophic gastritis. Our study group consisted of 17 patients: six with mild atrophic gastritis, seven with moderate atrophic gastritis and four with severe atrophic gastritis. None of the patients had type-A atrophic gastritis but the body mucosa was affected by superficial gastritis at various extent in some. A group of 15 healthy subjects served as control. All subjects underwent gastroscopic examination with multiple bioptic sampling. Radioimmunoassay was used for gastrin determination and photomicroscopy for gastrin producing cell density assessment. Electron microscopy was used to assess the gastrin producing granule density index. Patients with moderate and severe atrophic gastritis showed a lower gastric acidity and acid output as compared to control. Serum gastrin did not show significant differences among the groups. In moderate and severe atrophic gastritis, gastrin producing cell granule density index, gastrin producing cell density and antral mucosa gastrin concentration were significantly lower when compared with control and decreased with advancing of the severity of atrophic gastritis. In atrophic gastritis, however, the latter two measurements were not correlated. In moderate and severe atrophic gastritis luminal gastrin concentration significantly increased, compared with control, after the severity of atrophic gastritis. Gastrin producing cell granule density index and luminal gastrin concentration showed a significant correlation with gastric pH. These data suggest that in antral atrophic gastritis with reduced gastric acidity, the decrement of gastrin producing cells is followed by gastrin producing cell hyperfunction with increased luminal release of gastrin.<\/jats:p>","DOI":"10.1136\/gut.31.3.279","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"279-281","source":"Crossref","is-referenced-by-count":19,"title":["Relationship between gastrin cell number, serum, antral mucosa and luminal gastrin concentration and gastric acidity in antral atrophic gastritis."],"prefix":"10.1136","volume":"31","author":[{"given":"F","family":"Marotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Morello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sugai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3109\/00365527809181791","article-title":"Quantification of gastrinproducing cells and parietal cells in relation to histopathological alterations in resected stomachs from patients with peptic ulcer disease","volume":"13","author":"Stave, R.; Elgjio, K.; Brandtzaeg, P.","year":"1978","unstructured":"Stave R, Elgjio K, Brandtzaeg P. Quantification of gastrinproducing cells and parietal cells in relation to histopathological alterations in resected stomachs from patients with peptic ulcer disease. Scand J Gastroenterol 1978; 13: 747-57.","journal-title":"Scand J Gastroenterol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3109\/00365527809182201","article-title":"Fasting and food-stimulated serum gastrin concentration in relation to the antral G-cell population","volume":"13","author":"Stave, R.; Gedde-Dahl, D.; Gjone, E.","year":"1978","unstructured":"Stave R, Gedde-Dahl D, Gjone E. Fasting and food-stimulated serum gastrin concentration in relation to the antral G-cell population. ScandJ Gastroenterol 1978; 13: 845-9.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_3","first-page":"1718","article-title":"Gastrin cells and fasting serum gastrin levels in duodenal ulcer patients. A quantitative study based on multiple biopsy specimens","volume":"32","author":"Piris, J.; Whitehead, R.","year":"1979","unstructured":"Piris J, Whitehead R. Gastrin cells and fasting serum gastrin levels in duodenal ulcer patients. A quantitative study based on multiple biopsy specimens. J Clin Pathol 1979; 32: 1718.","journal-title":"J Clin Pathol"},{"key":"ref_4","first-page":"199203","article-title":"Immunohistochemical investigation of gastrin producing cells. ScandJ'","volume":"13","author":"Stave, R.; Brandtzaeg, P.","year":"1978","unstructured":"Stave R, Brandtzaeg P. Immunohistochemical investigation of gastrin producing cells. ScandJ' Gastroenterol 1978; 13: 199203.","journal-title":"Gastroenterol"},{"key":"ref_5","first-page":"737","article-title":"Variation in distribution of antral gastrin cells. Acta Pathol Microbiol Scand (sect A)","volume":"83","author":"Asnaes, S.; Johansen, A.","year":"1975","unstructured":"Asnaes S, Johansen A. Variation in distribution of antral gastrin cells. Acta Pathol Microbiol Scand (sect A) 1975; 83: 737-8."},{"key":"ref_6","article-title":"Mucosal biopsy of the gastrointestinal tract","author":"Whitehead, R.","year":"1973","unstructured":"Whitehead R. Mucosal biopsy of the gastrointestinal tract. Philadelphia: WB Saunders, 1973."},{"key":"ref_7","first-page":"90","article-title":"Immunocytochemistry","author":"Sternberger, L.A.","year":"1986","unstructured":"Sternberger LA. Immunocytochemistry. 3rd ed. New York: John Wiley, 1986: 90.","edition":"3rd ed"},{"key":"ref_8","first-page":"118","article-title":"In vivo release of gastrin into human gastric juice","volume-title":"BrJ3Surg","volume":"65","author":"Knight, N.F.; Fiddian-Green, R.G.; Vinik, A.","year":"1978","unstructured":"Knight NF, Fiddian-Green RG, Vinik A. In vivo release of gastrin into human gastric juice. BrJ3Surg 1978; 65: 118-20."},{"key":"ref_9","first-page":"745","article-title":"Mucosal gastrin forms of gastrin, number and ultrastructure of Gcells in patients with duodenal ulcer","volume-title":"Gut","volume":"17","author":"Creutzfeldt, W.; Arnold, R.; Creutzfeldt, C.; Track, N.S.","year":"1976","unstructured":"Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS. Mucosal gastrin forms of gastrin, number and ultrastructure of Gcells in patients with duodenal ulcer. Gut 1976; 17: 745-54."},{"key":"ref_10","first-page":"712","article-title":"G-cell counts in antral endoscopic biopsies by immunofluorescence. Scand J7 Gastroenterol","volume":"12","author":"Crivelli 0, Pera A, Ferrari A","year":"1977","unstructured":"Crivelli 0, Pera A, Ferrari A, et al. G-cell counts in antral endoscopic biopsies by immunofluorescence. Scand J7 Gastroenterol 1977; 12: 712-26."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(74)91199-4","article-title":"Plasma gastrin and acid secretion in patients with peptic ulcerations","volume":"ii:","author":"Wesdorp, R.I.C.; Fisher, J.E.","year":"1974","unstructured":"Wesdorp RIC, Fisher JE. Plasma gastrin and acid secretion in patients with peptic ulcerations. Lancet 1974; ii: 857-60.","journal-title":"Lancet"},{"key":"ref_12","first-page":"721","article-title":"Fasting serum gastrin and basal gastric acid secretion","volume":"10","author":"Petersen, H.; Schrumpf, E.; Myren, J.","year":"1975","unstructured":"Petersen H, Schrumpf E, Myren J. Fasting serum gastrin and basal gastric acid secretion. ScandJ7 Gastroenterol 1975; 10: 721-4."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/00365527809179823","article-title":"Quantitative studies of gastrin cells and parietal cells in relation to gastric acid secretion in patients with peptic ulcer disease","volume":"13","author":"Stave, R.; Myren, J.; Brandtzaeg, P.; Gjone, E.","year":"1978","unstructured":"Stave R, Myren J, Brandtzaeg P, Gjone E. Quantitative studies of gastrin cells and parietal cells in relation to gastric acid secretion in patients with peptic ulcer disease. Scand J Gastroenterol 1978; 13: 293-8.","journal-title":"Scand J Gastroenterol"},{"key":"ref_14","first-page":"101","article-title":"G-cell population and serum gastrin response to cimetidine-oxo test meal in relation to histopathological alterations in resected stomachs from patients with peptic ulcer disease","volume":"15","author":"Fujimoto, S.; Kimoto, K.; Inokuchi, H.; Kawai, K.; Yamashita, S.; Hattori, T.","year":"1980","unstructured":"Fujimoto S, Kimoto K, Inokuchi H, Kawai K, Yamashita S, Hattori T. G-cell population and serum gastrin response to cimetidine-oxo test meal in relation to histopathological alterations in resected stomachs from patients with peptic ulcer disease. GastroenterolJ7pn 1980; 15: 101-7."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000199004","article-title":"Hyperplasia of antral gastrin cells in uraemic patients","volume":"29","author":"Carlei, F.; Caruso, U.; Lezoche, E.","year":"1984","unstructured":"Carlei F, Caruso U, Lezoche E, et al. Hyperplasia of antral gastrin cells in uraemic patients. Digestion 1984; 29: 26-30.","journal-title":"Digestion"},{"key":"ref_16","first-page":"400","article-title":"Estimation of the antral and duodenal gastrin cell population removed by gastrectomy from patients with peptic ulcer","volume":"146","author":"Keuppens, F.; Vansteenkiste, Willems G.; Y, Woussen-Colle; M.C.","year":"1978","unstructured":"Keuppens F, Willems G. Vansteenkiste Y, Woussen-Colle MC. Estimation of the antral and duodenal gastrin cell population removed by gastrectomy from patients with peptic ulcer. Surg Gynecol Obstet 1978; 146: 400-6.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_17","first-page":"689","article-title":"G cell population of the gastric antrum, plasma gastrin, and gastric acid secretion in patients with and without duodenal ulcer","volume-title":"Gut","volume":"19","author":"Royston, C.M.S.; Polak, J.; Bloom, SR","year":"1978","unstructured":"Royston CMS, Polak J, Bloom SR, et al. G cell population of the gastric antrum, plasma gastrin, and gastric acid secretion in patients with and without duodenal ulcer. Gut 1978; 19: 689-98."},{"key":"ref_18","first-page":"352","article-title":"The presence of gastrin in fastingand stimulated gastric juice","volume":"72","author":"Jordan, P.H.; Yip, B.S.S.C.","year":"1972","unstructured":"Jordan PH, Yip BSSC. The presence of gastrin in fastingand stimulated gastric juice. Surgery 1972; 72: 352-6.","journal-title":"Surgery"},{"key":"ref_19","first-page":"663","article-title":"A physiological role for luminal gastrin?","volume":"83","author":"Fiddian-Green, R.G.; Farrell, J.; Havlichek, D.; Kothary, P.; Pittenger, G.","year":"1978","unstructured":"Fiddian-Green RG, Farrell J, Havlichek D, Kothary P, Pittenger G. A physiological role for luminal gastrin? Surgery 1978; 83: 663-8.","journal-title":"Surgery"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0167-0115(86)90214-4","article-title":"Antral gastrin-and somatostatin-producing cells and intraluminal peptide secretion in normal subjects and in duodenal ulcer patients with and without vagotomy","volume":"14","year":"1986","unstructured":"Gutierrez 0, Rene E, Accary JP, Bonfils S. Antral gastrin-and somatostatin-producing cells and intraluminal peptide secretion in normal subjects and in duodenal ulcer patients with and without vagotomy. Regul Pept 1986; 14: 133-43.","journal-title":"Regul Pept"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1172\/JCI107952","article-title":"pH dependence of acid secretion and gastrin release in normal and ulcer subjects","volume":"55","author":"Walsh, J.H.; Richardson, C.T.; Fordtan, J.S.","year":"1975","unstructured":"Walsh JH, Richardson CT, Fordtan JS. pH dependence of acid secretion and gastrin release in normal and ulcer subjects.JZ Clin Invest 1975; 55: 462-8.","journal-title":"JZ Clin Invest"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.31.3.279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T21:37:11Z","timestamp":1757281031000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.31.3.279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1990,3,1]]},"published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1136\/gut.31.3.279"],"URL":"https:\/\/doi.org\/10.1136\/gut.31.3.279","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}