{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:43:41Z","timestamp":1765611821990,"version":"3.48.0"},"reference-count":24,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:p>We have evaluated the effect of cisapride on interdigestive antroduodenal motility during a prolonged oral therapy in 20 consecutive dyspeptic subjects. Individuals with less than two migrating motor complexes (MMCs) starting from the antral region in 240 minutes and without evidence of upper gastrointestinal tract diseases were randomly treated with either cisapride (10 cases), or placebo (10 cases) for 15 days. Computerised manometry of antroduodenal region was performed for 240 minutes, in basal conditions and on the 15th day of therapy. Symptomatic evaluation of patients was also performed before and after treatment. After cisapride administration, a significant increase in the incidence of antral migrating motor complexes was noticed (p = 0.022); likewise, the motility index, calculated for phase-2 periods, appeared to be significantly higher both in the antrum and in the duodenum (p less than 0.001). Symptomatic improvement was observed in both groups, with a hardly significant (p = 0.049) reduction of dyspeptic symptoms severity only but not of frequency in cisapride treated patients v controls. We conclude that longterm oral therapy with cisapride improves interdigestive antroduodenal motor activity.<\/jats:p>","DOI":"10.1136\/gut.31.3.286","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"286-290","source":"Crossref","is-referenced-by-count":28,"title":["Longterm oral cisapride improves interdigestive antroduodenal motility in dyspeptic patients."],"prefix":"10.1136","volume":"31","author":[{"given":"P A","family":"Testoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Bagnolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Fanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Passaretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tittobello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0025-7125(16)31472-9","article-title":"Fisher RS. 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Scandj Gastroenterol 1982; 17: (Suppl 79): 6-8."},{"key":"ref_8","first-page":"1157","article-title":"Effect of cisapride on the motility of gut in dogs and colonic transit time","volume-title":"dogs and humans. [Abstract.] Gastroenterology","volume":"86","author":"Lee, K.Y.; Chey, W.Y.; You, C.H.; Shah, A.N.; Hamilton, D.","year":"1984","unstructured":"Lee KY, Chey WY, You CH, Shah AN, Hamilton D. Effect of cisapride on the motility of gut in dogs and colonic transit time in dogs and humans. [Abstract.] Gastroenterology 1984; 86:1157."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/gut.26.4.352","article-title":"Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride)","volume":"26","author":"Jian, R.; Ducrot, F.; Piedeloup, C.; Mary, J.Y.; Najean, Y.; Bernier, J.J.","year":"1985","unstructured":"Jian R, Ducrot F, Piedeloup C, Mary JY, Najean Y, Bernier JJ. Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride). Gut 1985; 26: 352-8.","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0016-5085(87)90976-0","article-title":"Intravenous cisapride accelerates delayed gastric emptying and increases antral contraction amplitude in patients with primary anorexia nervosa","volume":"92","author":"Stacher, G.; Bergmann, H.; Wiesnagrotzki, S.","year":"1987","unstructured":"Stacher G, Bergmann H, Wiesnagrotzki S, et al. Intravenous cisapride accelerates delayed gastric emptying and increases antral contraction amplitude in patients with primary anorexia nervosa. Gastroenterologv 1987; 92: 1000-6.","journal-title":"Gastroenterologv"},{"key":"ref_11","first-page":"161","article-title":"Cisapride in non-ulcer dyspepsia. Results of a placebo-controlled trial. Scand.7 Gastroenterol","volume":"22","author":"Rosch, W.","year":"1987","unstructured":"Rosch W. Cisapride in non-ulcer dyspepsia. Results of a placebo-controlled trial. Scand.7 Gastroenterol 1987; 22: 161-4."},{"key":"ref_12","first-page":"3005","article-title":"Effects of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis","volume":"28","author":"Corinaldesi, R.; Stanghellini, V.; Raiti, C.; Rea, E.; Salgemini, R.; Barbara, L.","year":"1987","unstructured":"Corinaldesi R, Stanghellini V, Raiti C, Rea E, Salgemini R, Barbara L. Effects of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis. 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The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 1977; 59: 1158-66.","journal-title":"J Clin Invest"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/0016-5085(86)90387-2","article-title":"Effects of cisapride of jejunal motor activity in fasting healthy humans","volume":"90","author":"Stacher, G.; Steinringer, H.; Schneider, C.; Winklehener, S.; Mittlebach, G.; Gaupmann, G.","year":"1986","unstructured":"Stacher G, Steinringer H, Schneider C, Winklehener S, Mittlebach G, Gaupmann G. Effects of cisapride of jejunal motor activity in fasting healthy humans. 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[Abstract.] Dig Dis Sci 1985; 30: 756.","journal-title":"[Abstract.] Dig Dis Sci"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.31.3.286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:41:20Z","timestamp":1765611680000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.31.3.286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1990,3,1]]},"published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1136\/gut.31.3.286"],"URL":"https:\/\/doi.org\/10.1136\/gut.31.3.286","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}