{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:24:05Z","timestamp":1765081445352,"version":"3.46.0"},"reference-count":13,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:p>Eighty patients with reflux oesophagitis were randomised to receive either Pyrogastrone five tablets daily or cimetidine 400 mg twice daily for six weeks, extended to 12 if necessary. At six weeks, 49% of the Pyrogastrone treated subjects and 37% of the cimetidine treated subjects were healed. After 12 weeks the cumulative healing rates were 64% for Pyrogastrone and 66% for cimetidine. Compared with baseline both drugs achieved similarly significant improvements in symptom score, endoscopic and histological grading even in those who did not heal completely. Response was not related to length of symptoms or initial severity of oesophagitis. Eleven of 25 (44%) patients healed with Pyrogastrone relapsed within one year compared with 15 of 27 (56%) healed with cimetidine. Although this trend in favour of Pyrogastrone was not significant at one year the early relapse rate was significantly greater in cimetidine treated subjects. At six weeks, five cimetidine treated subjects had relapsed compared with none in the Pyrogastrone group (p = 0.05). This study shows that Pyrogastrone and cimetidine are equally effective in the healing of oesophagitis and raises the possibility that Pyrogastrone has marginal benefits in terms of time to relapse.<\/jats:p>","DOI":"10.1136\/gut.31.3.351","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"351-354","source":"Crossref","is-referenced-by-count":5,"title":["Controlled trial of pyrogastrone and cimetidine in the treatment of reflux oesophagitis."],"prefix":"10.1136","volume":"31","author":[{"given":"D G","family":"Maxton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Heald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Whorwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N Y","family":"Haboubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM197508072930602","article-title":"Medical and surgical management of reflux oesophagitis","volume":"293","author":"Behar, J.; Sheahan, D.G.; Biancini, P.","year":"1975","unstructured":"Behar J, Sheahan DG, Biancini P, et al. Medical and surgical management of reflux oesophagitis. N Engli' Med 1975; 293: 263-8.","journal-title":"N Engli' Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1001\/archinte.1987.00370100031006","article-title":"Medical therapy for chronic reflux oesophagitis. Long term follow-up","volume":"147","author":"Liebermann, D.A.","year":"1987","unstructured":"Liebermann DA. Medical therapy for chronic reflux oesophagitis. Long term follow-up. Arch Intern Med 1987; 147: 1717-20.","journal-title":"Arch Intern Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1185\/03007997809110200","article-title":"Controlled trial of a carbenoxolone\/ alginate antacid combination in reflux oesophagitis","volume":"5","author":"Reed, P.I.; Davies, W.A.","year":"1978","unstructured":"Reed PI, Davies WA. Controlled trial of a carbenoxolone\/ alginate antacid combination in reflux oesophagitis. Curr Med Res Opin 1978; 5: 637-44.","journal-title":"Curr Med Res Opin"},{"key":"ref_4","first-page":"637","article-title":"Management of reflux oesophagitis","volume":"227","author":"Hamill, J.J.","year":"1983","unstructured":"Hamill JJ. Management of reflux oesophagitis. Practitioner 1983; 227: 637-9.","journal-title":"Practitioner"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0140-6736(78)91802-0","article-title":"Effect of cimetidine in symptomatic gastro-oesophageal reflux","volume":"ii:","author":"Powell-Jackson, P.; Barkley, H.; Northfield, T.C.","year":"1978","unstructured":"Powell-Jackson P, Barkley H, Northfield TC. Effect of cimetidine in symptomatic gastro-oesophageal reflux. 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Gastroenterology 1978; 74: 821-4.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"3","article-title":"Short-term treatment of duodenal ulceration","volume-title":"Cimetidine in the 80's","author":"Wormsley, K.G.","year":"1981","unstructured":"Wormsley KG. Short-term treatment of duodenal ulceration. In: Baron, JH, ed. Cimetidine in the 80's. Edinburgh: Churchill Livingstone, 1981: 3-8."},{"key":"ref_9","first-page":"1025","article-title":"Effect of long-term maintenance cimetidine therapy on gastroesophageal reflux disease","volume":"82","author":"Bright-Asare, P.; Behar, J.; Brand, D.L.","year":"1982","unstructured":"Bright-Asare P, Behar J, Brand DL, et al. Effect of long-term maintenance cimetidine therapy on gastroesophageal reflux disease. 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Gut 1987; 28: A1376-7."},{"key":"ref_12","first-page":"459","article-title":"Comparative study of carbenoxolone and cimetidine in the management of duodenal ulcer","volume":"46","author":"Reed, P.I.; Vincent-Brown, I.; Cook, P.J.","year":"1983","unstructured":"Reed PI, Vincent-Brown I, Cook PJ, et al. Comparative study of carbenoxolone and cimetidine in the management of duodenal ulcer. Acta Gastroenterol Belg 1983; 46: 459-68.","journal-title":"Acta Gastroenterol Belg"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/gut.29.2.181","article-title":"Influence of ulcer healing agents on ulcer relapse after discontinuation of acute treatment: a pooled estimate of controlled clinical trials","volume":"29","author":"Dobrilla, G.; Vallaperta, P.; Amplatz, S.","year":"1988","unstructured":"Dobrilla G, Vallaperta P, Amplatz S. Influence of ulcer healing agents on ulcer relapse after discontinuation of acute treatment: a pooled estimate of controlled clinical trials. 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