{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:50:44Z","timestamp":1765641044993,"version":"3.48.0"},"reference-count":19,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:p>Cell counts and measurements of mucosal architecture were made on rectal biopsies from nine patients with total colitis, eight with left sided colitis, 15 with distal colitis, and 11 with proctitis. The mean total lamina propria cell count in proctitis and distal colitis approached twice that of extensive left sided and total colitis (p less than 0.001) and in distal proctocolitis the cell numbers are further increased in the chronic over the acute phase. This difference was not explained by age, duration, activity, or treatment. The predominantly increased lymphoid and mononuclear cell infiltrate in distal proctocolitis indicates a different pattern of immune response, suggesting a separate process from extensive colitis or a more intense reaction resulting in localisation of disease.<\/jats:p>","DOI":"10.1136\/gut.31.4.426","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"426-430","source":"Crossref","is-referenced-by-count":26,"title":["Ulcerative colitis: one disease or two? (Quantitative histological differences between distal and extensive disease)."],"prefix":"10.1136","volume":"31","author":[{"given":"D","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Goodall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B B","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,4,1]]},"reference":[{"key":"ref_1","first-page":"101","article-title":"Idiopathic proctitis","volume-title":"bowel diseases","author":"Allan, R.N.","year":"1983","unstructured":"Ritchie JK, Hawley PR. Idiopathic proctitis. In: Allan RN, Keighley MRB, Alexander-Williams J, Hawkins C, eds. Inflammatory bowel diseases. Edinburgh: Churchill Livingstone, 1983: 101-6."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/BF02587263","article-title":"Emerging Concepts of Proctosigmoiditis","volume":"15","author":"Farmer, R.G.; Brown, C.H.","year":"1972","unstructured":"Farmer RG, Brown CH. Emerging Concepts of Proctosigmoiditis. Dis Colon Rectum 1972; 15: 142-6.","journal-title":"Dis Colon Rectum"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00004836-197903000-00006","article-title":"Long-term prognosis for patients with ulcerative proctosigmoiditis (ulcerative colitis confined to the rectum and sigmoid colon)","volume":"8","author":"Farmer, R.G.","year":"1979","unstructured":"Farmer RG. Long-term prognosis for patients with ulcerative proctosigmoiditis (ulcerative colitis confined to the rectum and sigmoid colon). ] Clin Gastroenterol 1979; 8: 47-50.","journal-title":"Clin Gastroenterol"},{"issue":"1046-5","key":"ref_4","first-page":"1","article-title":"Change in the extent of colonic involvement in ulcerative colitis: a colonoscopic study. Am]7 Gastroenterol","volume":"10","author":"Niv, Y.; Bat, L.; Ron, E.; Theodor, E.","year":"1987","unstructured":"Niv Y, Bat L, Ron E, Theodor E. Change in the extent of colonic involvement in ulcerative colitis: a colonoscopic study. Am]7 Gastroenterol 1987; 10: 1046-5 1. S Gabrielsson N, Granqvist S, Sundelin P, Thorgeirsson T. Extent of inflammatory lesions in ulcerative colitis assessed by radiology, colonoscopy, and endoscopic biopsies. 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Scand]7 Gastroenterol 1977; 12: 727-32."},{"key":"ref_7","first-page":"1140","article-title":"Clinical outcome of the first ten years of ulcerative colitis and proctitis","volume":"i:","author":"Ritchie, J.K.; Powell-Tuck, J.; Lennard-Jones, J.E.","year":"1978","unstructured":"Ritchie JK, Powell-Tuck J, Lennard-Jones JE. Clinical outcome of the first ten years of ulcerative colitis and proctitis. Lancet 1978; i: 1140-3.","journal-title":"Lancet"},{"key":"ref_8","first-page":"224","article-title":"A ten-year follow-up of haemorrhagic proctitis","volume":"52","author":"Myers, A.; Humphrevs, D.M.; Cox, E.V.","year":"1976","unstructured":"Myers A, Humphrevs DM, Cox EV. A ten-year follow-up of haemorrhagic proctitis. Postgrad Medj7 1976; 52: 224-8."},{"key":"ref_9","first-page":"314","article-title":"Lymphoid follicular proctitis. 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