{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:33:51Z","timestamp":1757619231407,"version":"3.44.0"},"reference-count":61,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:p>A randomised controlled multicentre trial was performed in 160 patients with gastric ulcer, proved by endoscopy and biopsy, to compare ulcer healing with sucralfate and ranitidine (double blind double dummy design) and to assess the effect of maintenance treatment with sucralfate on ulcer recurrence (double blind placebo controlled design). The healing rates were similar with 4 g sucralfate suspension per day and 300 mg ranitidine per day (82% and 88% after 12 weeks, respectively). Of the 109 patients with healed ulcers, 92 were entered into the maintenance trial and treated with sucralfate tablets (2 g per day) or placebo tablets. Maintenance treatment with sucralfate delayed symptoms of gastric ulcer recurrence. Lifetable analysis showed significant differences between sucralfate and placebo, both after six months (p = 0.018) and after 12 months (p = 0.044). The rates of symptom recurrences were 13% and 34% after six months and 34% and 55% after 12 months for sucralfate and placebo, respectively. The rate of asymptomatic recurrences after 12 months was similar in the two groups (9% and 10%, respectively). The recurrence rate was higher in patients who had never taken non-steroidal anti-inflammatory drugs than in those who had but had stopped on admission to the study. It was also higher in patients with recurrent ulcer and in those with scarring deformation and narrowing of the pylorus. Maintenance treatment with sucralfate slowed the appearance of symptom recurrences of gastric ulcer.<\/jats:p>","DOI":"10.1136\/gut.31.7.825","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"825-830","source":"Crossref","is-referenced-by-count":17,"title":["Sucralfate in the treatment and prevention of gastric ulcer: multicentre double blind placebo controlled study."],"prefix":"10.1136","volume":"31","author":[{"given":"A L","family":"Blum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Bethge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Bode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Domschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Feurle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hackenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"H\u00fcttemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Kachel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/gut.29.2.181","article-title":"Influence of ulcer healing agents on ulcer relapse after discontinuation of acute treatment: a pooled estimate of controlled clinical trials","volume":"29","author":"Dobrilla, G.; Vallaperta, P.; Amplatz, S.","year":"1988","unstructured":"Dobrilla G, Vallaperta P, Amplatz S. Influence of ulcer healing agents on ulcer relapse after discontinuation of acute treatment: a pooled estimate of controlled clinical trials. Gut 1988; 29: 181-7.","journal-title":"Gut"},{"key":"ref_2","first-page":"429","article-title":"Relapse rates after initial ulcer healing with sucralfate and cimetidine","volume":"17","author":"Marks, I.N.; Wright, J.P.; Lucke, W.; Girdwood, A.H.","year":"1982","unstructured":"Marks IN, Wright JP, Lucke W, Girdwood AH. Relapse rates after initial ulcer healing with sucralfate and cimetidine. ScandJ3 Gastroenterol 1982; 17: 429-32."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/gut.23.6.545","article-title":"Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy","volume":"23","author":"Morgan, A.G.; McAdam, W.A.F.; Pacsoo, C.; Darnborough, A.","year":"1982","unstructured":"Morgan AG, McAdam WAF, Pacsoo C, Darnborough A. Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy. Gut 1982; 23: 545-51.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01312725","article-title":"Endoscopic evaluation of the effect of sucralfate therapy and other clinical parameters on the recurrence rate of gastric ulcer","volume":"25","author":"Miyake, T.; Ariyoshi, J.; Suzaki, T.; Oishi, M.; Sakai, M.; Ueda, S.","year":"1980","unstructured":"Miyake T, Ariyoshi J, Suzaki T, Oishi M, Sakai M, Ueda S. Endoscopic evaluation of the effect of sucralfate therapy and other clinical parameters on the recurrence rate of gastric ulcer. 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Hepatogastroenterology 1980; (suppl June): A205.","journal-title":"Hepatogastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/pgmj.55.644.393","article-title":"Cimetidine in the prevention of gastric ulcer relapse","volume":"55","author":"Machell, R.J.; Ciclitira, P.J.; Farthing, M.J.G.; Dick, A.P.; Hunter, J.O.","year":"1979","unstructured":"Machell RJ, Ciclitira PJ, Farthing MJG, Dick AP, Hunter JO. Cimetidine in the prevention of gastric ulcer relapse. Postgrad MedJ7 1979; 55: 393-5.","journal-title":"Postgrad MedJ7"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1136\/gut.26.6.599","article-title":"Maintenance therapy: a two year comparison between Caved-S and cimetidine treatment in the prevention of symptomatic gastric ulcer recurrence","volume":"26","author":"Morgan, A.G.; Pacsoo, C.; McAdam, W.A.F.","year":"1985","unstructured":"Morgan AG, Pacsoo C, McAdam WAF. 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ScandJ Gastroenterol 1987; 22: 397-405.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/gut.24.5.418","article-title":"Ranitidine in the prevention of gastric and duodenal ulcer relapse","volume":"24","author":"Alstead, E.M.; Ryan, F.P.; Holdsworth, C.D.; Ashton, M.G.; Moore, M.","year":"1983","unstructured":"Alstead EM, Ryan FP, Holdsworth CD, Ashton MG, Moore M. Ranitidine in the prevention of gastric and duodenal ulcer relapse. Gut 1983; 24: 418-20.","journal-title":"Gut"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/00365521.1984.12005790","article-title":"Effect of ranitidine and cimetidine on gastric ulcer healing and recurrence","volume":"19","author":"Dawson, J.; Jain, S.; Cockel, R.","year":"1984","unstructured":"Dawson J, Jain S, Cockel R. Effect of ranitidine and cimetidine on gastric ulcer healing and recurrence. Scand J Gastroenterol 1984; 19: 665-8.","journal-title":"Scand J Gastroenterol"},{"key":"ref_23","first-page":"180","article-title":"Ranitidine in the maintenance therapy of gastro-duodenal ulcer disease: Polish open multicentre study","volume":"31","author":"Gibinski, K.; Nowak, A.; Gabryelewicz, A.","year":"1984","unstructured":"Gibinski K, Nowak A, Gabryelewicz A, et al. Ranitidine in the maintenance therapy of gastro-duodenal ulcer disease: Polish open multicentre study. Hepatogastroenterology 1984; 31: 180-2.","journal-title":"Hepatogastroenterology"},{"key":"ref_24","first-page":"134","article-title":"Ranitidine in the treatment of gastric ulcers: healing and maintenance","volume":"78","author":"Hellier, M.D.; Gent, A.E.; Walker, J.; Britten, D.; Hutchison, C.; Cough, K.R.","year":"1982","unstructured":"Hellier MD, Gent AE, Walker J, Britten D, Hutchison C, Cough KR. Ranitidine in the treatment of gastric ulcers: healing and maintenance. Scand J Gastroenterol 1982; 17 (suppl 78): 134.","journal-title":"Scand J Gastroenterol"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/gut.28.4.460","article-title":"Ranitidine 150 mg at night in the prevention of gastric ulcer relapse","volume":"28","author":"Jorde, R.; Burhol, P.G.; Hansen, T.","year":"1987","unstructured":"Jorde R, Burhol PG, Hansen T. Ranitidine 150 mg at night in the prevention of gastric ulcer relapse. Gut 1987; 28: 460-3.","journal-title":"Gut"},{"key":"ref_26","first-page":"387","article-title":"Ranitidina e recidive dell'ulcera peptica, duodenale e gastrica: studio aperto a lungo termine. Osservazioni preliminari","volume-title":"Gastroenterologia e Ranitidina","author":"Picciotto, A.; Canepa, A.; Gismindi, C.; Dodero, M.; Celle, G.","year":"1984","unstructured":"Picciotto A, Canepa A, Gismindi C, Dodero M, Celle G. Ranitidina e recidive dell'ulcera peptica, duodenale e gastrica: studio aperto a lungo termine. 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Maintenance therapy with carbonic anhydrase inhibitors in the prevention of gastric and duodenal ulcer relapses. Gastroenterology 1985; 88: A1339.","journal-title":"Gastroenterology"},{"issue":"83","key":"ref_31","first-page":"61","article-title":"Effect of sucralfate on peptic ulcer recurrence: a controlled double-blind multicentre study","volume":"18","author":"Classen, M.; Bethge, H.; Brunner, G.","year":"1983","unstructured":"Classen M, Bethge H, Brunner G, et al. Effect of sucralfate on peptic ulcer recurrence: a controlled double-blind multicentre study. Scand J Gastroenterol 1983; 18 (suppl 83): 61-8.","journal-title":"Scand J Gastroenterol"},{"key":"ref_32","first-page":"321","article-title":"Traitement d'entretien de la maladie ulcereuse: etude multicentrique comparative du sucralfate, de la cimetidine et d'un placebo","volume":"6","author":"Jean, F.; Bonnefond, A.; Gislon, J.","year":"1985","unstructured":"Jean F, Bonnefond A, Gislon J, et al. 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