{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:53:21Z","timestamp":1757620401167,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:p>In order to investigate the response of gastro-oesophageal reflux after medically induced healing of oesophagitis and its relation to the occurrence of relapse during prophylactic treatment, 20 patients with erosive\/ulcerative oesophagitis underwent 24 hour oesophageal pH monitoring before and after healing achieved with 12 to 24 week treatment with ranitidine 150 or 300 mg twice daily. Compared with pretreatment values, after macroscopic healing, a significant reduction in daytime median percentage of reflux time (10.0 v 6.5; p less than 0.05) and median number of reflux episodes lasting more than 5 minutes (5-5 v 1.0; p less than 0.05) were observed, whereas during night time reflux frequency and severity did not change. During maintenance treatment with ranitidine 150 or 300 mg nocte, five of the six patients, who had shown no improvement in gastro-oesophageal reflux after acute healing, relapsed. These results suggest that, in contrast with previous work, a decrease in gastro-oesophageal reflux in patients with reflux oesophagitis can be achieved after macroscopic healing, and that the occurrence of such a reduction after acute healing is predictive of a good response to longterm treatment.<\/jats:p>","DOI":"10.1136\/gut.31.9.1025","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1025-1029","source":"Crossref","is-referenced-by-count":9,"title":["Daytime reduction of gastro-oesophageal reflux after healing of oesophagitis and its value as an indicator of favourable response to maintenance treatment."],"prefix":"10.1136","volume":"31","author":[{"given":"F","family":"Pace","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Sangaletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Bianchi Porro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0300-5089(21)00693-3","article-title":"Endoscopy as final arbiter in controlled clinical trials in peptic disorders","volume":"15","author":"Meier, R.F.; Sieber, R.; Bauerfeind, P.; Blum, A.L.","year":"1986","unstructured":"Meier RF, Sieber R, Bauerfeind P, Blum AL. Endoscopy as final arbiter in controlled clinical trials in peptic disorders. Clin Gastroenterol 1986; 15: 377-91.","journal-title":"Clin Gastroenterol"},{"key":"ref_2","first-page":"297","article-title":"When is esophagitis healed? Esophageal endoscopy, histology and function before and after cimetidine treatment","volume":"27","author":"Sonnenberg, A.; Lepsien, G.; Mueller-Lissner, S.A.; Koelz, H.R.; Siewert, JR, Blum; A.L.","year":"1982","unstructured":"Sonnenberg A, Lepsien G, Mueller-Lissner SA, Koelz HR, Siewert JR, Blum AL. When is esophagitis healed? Esophageal endoscopy, histology and function before and after cimetidine treatment. Dig Dis Sci 1982; 27: 297-302.","journal-title":"Dig Dis Sci"},{"key":"ref_3","first-page":"744","article-title":"Abnormal esophageal pressure in reflux oesophagitis: cause or effect?","volume":"81","author":"Katz, P.O.; Knuff, T.E.; Benjamin, S.B.; Castell, D.O.","year":"1986","unstructured":"Katz PO, Knuff TE, Benjamin SB, Castell DO. Abnormal esophageal pressure in reflux oesophagitis: cause or effect? AmJ Gastroenterol 1986; 81: 744-6.","journal-title":"AmJ Gastroenterol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/gut.29.2.157","article-title":"Oesophageal function before, during, and after healing of erosive oesophagitis","volume":"29","author":"Baldi, F.; Ferrarini, F.; Longanesi, A.","year":"1988","unstructured":"Baldi F, Ferrarini F, Longanesi A, et al. Oesophageal function before, during, and after healing of erosive oesophagitis. Gut 1988; 29: 157-60.","journal-title":"Gut"},{"key":"ref_5","first-page":"161","article-title":"Does healing of esophagitis improve esophageal motor function?","volume":"33","author":"Eckardt, V.F.","year":"1988","unstructured":"Eckardt VF. Does healing of esophagitis improve esophageal motor function? 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Ann Intern Med 1982; 97: 93-103.","journal-title":"Ann Intern Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3109\/00365528809093943","article-title":"Comparison of three methods of intraesophageal pH recordings in the diagnosis of gastroesophageal reflux","volume":"23","author":"G, Bianchi Porro; F, Pace","year":"1988","unstructured":"Bianchi Porro G, Pace F. Comparison of three methods of intraesophageal pH recordings in the diagnosis of gastroesophageal reflux. Scand J Gastroenterol 1988; 23: 743-50.","journal-title":"Scand J Gastroenterol"},{"key":"ref_11","article-title":"The esophagus. Handbook and atlas of endoscopy","author":"Savary, M.; Miller, G.","year":"1977","unstructured":"Savary M, Miller G. The esophagus. Handbook and atlas of endoscopy. Solothurn: Gassmann, 1977."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1136\/gut.28.9.1177","article-title":"Technical aspects of intraluminal pH-metry in man: current status and recommendations","volume":"28","author":"Emde, C.; Garner, A.; Blum, A.L.","year":"1987","unstructured":"Emde C, Garner A, Blum AL. Technical aspects of intraluminal pH-metry in man: current status and recommendations. Gut 1987; 28: 1177-88.","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0016-5085(87)90318-0","article-title":"Optimal thresholds, sensitivity and specificity of long-term pH-metry for the detection of gastroesophageal reflux disease","volume":"93","author":"Schindlek, N.E.; Neinrich, C.; Koenig, A.; Dendorfer, A.; Pace, F.; Muller-Lissner, S.A.","year":"1987","unstructured":"Schindlek NE, Neinrich C, Koenig A, Dendorfer A, Pace F, Muller-Lissner SA. 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Gut 1988; 29: 886-9.","journal-title":"Gut"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3109\/00365528708991937","article-title":"Acid gastrooesophageal reflux and oesophageal pressure activity during postprandial and nocturnal periods. A study in subjects with and without pathologic acid gastro-oesophageal reflux","volume":"22","author":"Kruse-Andersen, S.; Wallin, L.; Madsen, T.","year":"1987","unstructured":"Kruse-Andersen S, Wallin L, Madsen T. Acid gastrooesophageal reflux and oesophageal pressure activity during postprandial and nocturnal periods. A study in subjects with and without pathologic acid gastro-oesophageal reflux. ScandJ Gastroenterol 1987; 22: 926-30.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00000658-197610000-00009","article-title":"Patterns of gastroesophageal reflux in health and disease","volume":"184","author":"DeMeester, T.R.; Johnson, L.F.; Joseph, G.J.; Toscano, M.S.; Hall, A.W.; Skinner, D.B.","year":"1976","unstructured":"DeMeester TR, Johnson LF, Joseph GJ, Toscano MS, Hall AW, Skinner DB. Patterns of gastroesophageal reflux in health and disease. Ann Surg 1976; 184: 459-70.","journal-title":"Ann Surg"},{"key":"ref_18","first-page":"656","article-title":"Technique, indications and clinical use of 24 hour esophageal pH monitoring..7 Thorac Cardiovasc Surg","volume":"79","author":"DeMeester, T.R.; Wang, C.I.; Wernly, J.A.","year":"1980","unstructured":"DeMeester TR, Wang CI, Wernly JA, et al. Technique, indications and clinical use of 24 hour esophageal pH monitoring..7 Thorac Cardiovasc Surg 1980; 79: 656-70."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gut.29.8.1020","article-title":"Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastrooesophageal reflux","volume":"29","author":"Dent, J.; Holloway, R.H.; Toouli, J.; Dodds, W.J.","year":"1988","unstructured":"Dent J, Holloway RH, Toouli J, Dodds WJ. Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastrooesophageal reflux. Gut 1988; 29: 1020-8.","journal-title":"Gut"},{"key":"ref_20","first-page":"139","article-title":"Gastroesophageal reflux disease. Acute and maintenance treatment with cimetidine","volume":"21","author":"Kaul, B.; Petersen, H.; Erichsen, H.; et at","year":"1986","unstructured":"Kaul B, Petersen H, Erichsen H, et at. Gastroesophageal reflux disease. Acute and maintenance treatment with cimetidine. ScandJGastroenterol 1986; 21: 139-45.","journal-title":"ScandJGastroenterol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0016-5085(86)80017-8","article-title":"Healing and relapse of reflux esophagitis during treatment with ranitidine","volume":"91","author":"Koelz, H.R.; Birchier, R.; Bretholz, A.; et at","year":"1986","unstructured":"Koelz HR, Birchier R, Bretholz A, et at. Healing and relapse of reflux esophagitis during treatment with ranitidine. 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