{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:56:44Z","timestamp":1765691804646,"version":"3.48.0"},"reference-count":29,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:p>A manometric study to determine the role of gastro-oesophageal reflux in Barrett's oesophagus was performed on 20 patients with Barrett's oesophagus and 53 patients with reflux oesophagitis without Barrett's oesophagus (25 with mild oesophagitis and 28 with severe oesophagitis). For the same reason, the 20 patients with Barrett's oesophagus also underwent 24 hour continuous oesophageal pH monitoring, and the results obtained were compared with those of 20 oesophagitis patients without Barrett's oesophagus (10 with mild oesophagitis and 10 with severe oesophagitis). The manometric results show that the motor changes found in the Barrett's group are specific but similar to the motor dysfunction associated with reflux oesophagitis. Motor anomalies are probably related more to the inflammatory process in the oesophageal wall than to the metaplastic changes themselves. The pH monitoring results show that while reflux in the Barrett's oesophagus patients was greater overall than in the oesophagitis group without Barrett's oesophagus, the changes are similar when the results are compared with the severe oesophagitis group. In conclusion there are other factors besides gastro-oesophageal reflux involved in the pathogenesis of Barrett's oesophagus.<\/jats:p>","DOI":"10.1136\/gut.31.9.964","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"964-967","source":"Crossref","is-referenced-by-count":57,"title":["Evaluation of the magnitude of gastro-oesophageal reflux in Barrett's oesophagus."],"prefix":"10.1136","volume":"31","author":[{"given":"P","family":"Parrilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L F","family":"Martinez de Haro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Aguayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,9,1]]},"reference":[{"key":"ref_1","first-page":"175","article-title":"Chronic peptic ulcer of the oesophagus and oesophagitis","volume":"38","author":"Barrett, N.R.","year":"1950","unstructured":"Barrett NR. Chronic peptic ulcer of the oesophagus and oesophagitis. BrjSurg 1950; 38: 175-82.","journal-title":"BrjSurg"},{"key":"ref_2","first-page":"104","article-title":"Barrett syndrome: case report with discussion about","volume-title":"concepts of pathogenesis. Gastroenterology 1960","volume":"39","author":"Goldman, M.C.; Beckman, R.C.","unstructured":"Goldman MC, Beckman RC. Barrett syndrome: case report with discussion about concepts of pathogenesis. Gastroenterology 1960; 39: 104-10."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0016-5085(66)80127-0","article-title":"The columnar-lined esophagus (Barrett syndrome): an acquired condition?","volume":"50","author":"Mossberg, S.M.","year":"1976","unstructured":"Mossberg SM. The columnar-lined esophagus (Barrett syndrome): an acquired condition? Gastroenterology 1976; 50: 671-6.","journal-title":"Gastroenterology"},{"key":"ref_4","first-page":"683","article-title":"The Barrett syndrome (Te columnar-lined lower esophagus): an acquired condition secondary to reflux esophagitis; a case report with discussion of pathogenesis","volume":"141","author":"Halvorsen, J.F.; Semb, B.K.H.","year":"1975","unstructured":"Halvorsen JF, Semb BKH. The Barrett syndrome (Te columnar-lined lower esophagus): an acquired condition secondary to reflux esophagitis; a case report with discussion of pathogenesis. Acta ChirScand 1975; 141: 683-7.","journal-title":"Acta ChirScand"},{"key":"ref_5","first-page":"20916","article-title":"Barrett's esophagus: congenital or acquired?: an experimental study of esophageal mucosal regeneration in the dog","volume":"68","author":"Bremner, C.G.; Lynch, V.P.; FHJr, Ellis","year":"1970","unstructured":"Bremner CG, Lynch VP, Ellis FHJr. Barrett's esophagus: congenital or acquired?: an experimental study of esophageal mucosal regeneration in the dog. Surgery 1970; 68: 20916.","journal-title":"Surgery"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0016-5085(77)80152-2","article-title":"Regeneration of cardiac type mucosa and acquisition of Barrett mucosa after esophagogastrostomy","volume":"72","author":"Hamilton, SR, Yardley; J.H.","year":"1977","unstructured":"Hamilton SR, Yardley JH. Regeneration of cardiac type mucosa and acquisition of Barrett mucosa after esophagogastrostomy. Gastroenterology 1977; 72: 669-75.","journal-title":"Gastroenterology"},{"key":"ref_7","first-page":"29","article-title":"Pathogenesis of columnar cell-lined (Barrett's) esophagus","volume-title":"esophagus: pathophysiology, diagnosis and management","author":"Hamilton, SR","year":"1985","unstructured":"Hamilton SR. Pathogenesis of columnar cell-lined (Barrett's) esophagus. In: Spechler SJ, Goyal RK, eds. Barrett's esophagus: pathophysiology, diagnosis and management. New York: Elsevier Science, 1985: 29-37."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0002-9343(83)90635-6","article-title":"Barrett's esophagus: a review","volume":"74","author":"RWJr, Siogren; LF, Johnson","year":"1983","unstructured":"Siogren RWJr, Johnson LF. Barrett's esophagus: a review. Amj Med 1983; 74: 313-21.","journal-title":"Amj Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/bjs.1800750208","article-title":"Experimental columnar metaplasia in the canine oesophagus","volume":"75","author":"Gillen, P.; Keeling, P.; Byrne, P.J.; West, A.B.; Hennessy, T.P.J.","year":"1988","unstructured":"Gillen P, Keeling P, Byrne PJ, West AB, Hennessy TPJ. Experimental columnar metaplasia in the canine oesophagus. BrJ Surg 1988; 75: 113-5.","journal-title":"BrJ Surg"},{"key":"ref_10","first-page":"\"895","article-title":"Enzyme and ultrastructural characteristics of esophageal columnar epithelium","volume":"19","author":"Berenson, M.N.; Herbst, J.J.; Freston, J.W.","year":"1974","unstructured":"Berenson MN, Herbst JJ, Freston JW. Enzyme and ultrastructural characteristics of esophageal columnar epithelium. AmJ Dig Dis 1974; 19: 895-907. 1 1 Kortan P, Warren RE, Gardner J, et al. Barrett's esophagus in a patient with surgically treated achalasia. J Clin Gastroenterol 1981; 3: 357-60.","journal-title":"AmJ Dig Dis; Barrett's esophagus in a patient with surgically treated achalasia"},{"key":"ref_11","first-page":"12","article-title":"Barrett esophagus following total gastrectomy","volume":"11","author":"Meyer, W.; Vollmar, F.; Bar, W.","year":"1979","unstructured":"Meyer W, Vollmar F, Bar W. Barrett esophagus following total gastrectomy. Endoscopy 1979; 11: 12 1-6.","journal-title":"Endoscopy"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0022-5223(19)39666-7","article-title":"Columnar lined lower esophagus: an acquired lesion with malignant predisposition","volume":"70","author":"Naef, A.P.; Savary, M.; Ozello, L.","year":"1975","unstructured":"Naef AP, Savary M, Ozello L. Columnar lined lower esophagus: an acquired lesion with malignant predisposition. J Thorac Cardiovasc Surg 1975; 70: 826-35.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_13","first-page":"543","article-title":"Conservative operation for peptic esophagitis with stenosis and columnar-lined lower esophagus","volume":"13","author":"Naef, A.P.; Savary, M.","year":"1972","unstructured":"Naef AP, Savary M. Conservative operation for peptic esophagitis with stenosis and columnar-lined lower esophagus. Ann ThoracSurg 1972; 13: 543-57."},{"issue":"48-5","key":"ref_14","first-page":"1","article-title":"A case of Barrett epithelization followed up for five years","volume":"6","author":"Endo, M.; Kobayashi, S.; Koshu, T.","year":"1974","unstructured":"Endo M, Kobayashi S, Koshu T, et al. A case of Barrett epithelization followed up for five years. Endoscopy 1974; 6: 48-5 1.","journal-title":"Endoscopy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-5223(19)32896-X","article-title":"The lower esophagus lined by columnar epithelium: its association with hiatal hernia, ulcer, stricture and tumor","volume":"45","author":"Adler, R.H.","year":"1963","unstructured":"Adler RH. The lower esophagus lined by columnar epithelium: its association with hiatal hernia, ulcer, stricture and tumor. J Thorac Cardiovasc Surg 1963; 45: 13-32.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/BF01076195","article-title":"Gastrin content of columnar mucosa lining the lower (Barrett's) esophagus","volume":"22","author":"Dalton, M.D.; McGuigan, J.E.; Camp, R.C.; Goyal, R.K.","year":"1977","unstructured":"Dalton MD, McGuigan JE, Camp RC, Goyal RK. Gastrin content of columnar mucosa lining the lower (Barrett's) esophagus. AmJ Dig Dis 1977; 22: 970-2.","journal-title":"AmJ Dig Dis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0016-5085(19)31675-0","article-title":"Gastrin-producing cells in ectopic gastric mucosa of developmental and metaplastic origins","volume":"75","author":"Dayal, Y.; Wolfe, H.G.","year":"1978","unstructured":"Dayal Y, Wolfe HG. Gastrin-producing cells in ectopic gastric mucosa of developmental and metaplastic origins. Gastroenterology 1978; 75: 655-60.","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0022-5223(19)40115-3","article-title":"Columnar cell-lined esophagus assessment of etiology and treatment: a 22-year experience","volume":"71","author":"Borrie, J.; Goldwater, L.","year":"1976","unstructured":"Borrie J, Goldwater L. Columnar cell-lined esophagus assessment of etiology and treatment: a 22-year experience. J Thorac Cardiovasc Surg 1976; 71: 825-54.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1056\/NEJM198608073150605","article-title":"Barrett's esophagus","volume":"6","author":"Spechler, S.J.; Goyal, R.K.","year":"1986","unstructured":"Spechler SJ, Goyal RK. Barrett's esophagus. N Engl J Med 1986; 6:362-71.","journal-title":"N Engl J Med"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1001\/archsurg.1983.01390050027005","article-title":"Barrett's esophagus, functional assessment, proposed pathogenesis and surgical therapy","volume":"118","author":"Iascone, C.; Demeester, T.R.; Little, A.G.; Skinner, D.B.","year":"1983","unstructured":"Iascone C, Demeester TR, Little AG, Skinner DB. Barrett's esophagus, functional assessment, proposed pathogenesis and surgical therapy. Arch Surg 1983; 118: 543-9.","journal-title":"Arch Surg"},{"key":"ref_21","series-title":"Gut","first-page":"1007","article-title":"Gastro-oesophageal reflux (GER) in patients with esophagitis or a columnar lined (Barrett's) oesophagus","volume":"24","author":"Flook, D.; Stoddard, C.J.","year":"1983","unstructured":"Flook D, Stoddard CJ. Gastro-oesophageal reflux (GER) in patients with esophagitis or a columnar lined (Barrett's) oesophagus [Abstract]. Gut 1983; 24: A1007."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/bjs.1800740906","article-title":"Barrett's esophagus: pH profile","volume":"74","author":"Gillen, P.; Keeling, P.; Byrne, P.J.; Hennessy, T.P.J.","year":"1987","unstructured":"Gillen P, Keeling P, Byrne PJ, Hennessy TPJ. Barrett's esophagus: pH profile. BrJ Surg 1987; 74: 774-6.","journal-title":"BrJ Surg"},{"key":"ref_23","first-page":"261","article-title":"Datos manometricos en la achalasia de cardias (17 casos)","volume":"1","author":"de Haro LF, Martinez; T, Soria Cogollos; A, Ortiz Escandell; JL, Ponce Marco; F, Martinez Ripoll; P, Parrilla Paricio","year":"1981","unstructured":"Martinez de Haro LF, Soria Cogollos T, Ortiz Escandell A, Ponce Marco JL, Martinez Ripoll F, Parrilla Paricio P. Datos manometricos en la achalasia de cardias (17 casos). Acta Chir Catal 1981; 1: 261-76.","journal-title":"Acta Chir Catal"},{"key":"ref_24","first-page":"325","article-title":"Twenty-four hour monitoring of the distal esophagus: A quantitative measure of gastroesophageal reflux. AmJ'","volume":"62","author":"Johnson, L.F.; De Meester, T.R.","year":"1974","unstructured":"Johnson LF, De Meester TR. Twenty-four hour monitoring of the distal esophagus: A quantitative measure of gastroesophageal reflux. AmJ' Gastroenterol 1974; 62: 325-32.","journal-title":"Gastroenterol"},{"key":"ref_25","first-page":"195","article-title":"Gastroesophageal reflux disease and its complications with a critical analysis of treatment","volume-title":"Diseases of the esophagus","author":"Mehar, J.","year":"1982","unstructured":"Mehar J. Gastroesophageal reflux disease and its complications with a critical analysis of treatment. In: Cohen S, Soloway RD, eds. Diseases of the esophagus. New York: Churchill Livingstone, 1982: 195-213."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0016-5085(84)80012-8","article-title":"Barrett's esophagus: clinical, endoscopic, histologic, manometric and electrical potential characteristics","volume":"86","author":"Herlihy, K.J.; Orlando, R.C.; Bryson, J.C.; Bozymski, E.M.; ChN, Carney; Powell, D.W.","year":"1984","unstructured":"Herlihy KJ, Orlando RC, Bryson JC, Bozymski EM, Carney ChN, Powell DW. Barrett's esophagus: clinical, endoscopic, histologic, manometric and electrical potential characteristics. Gastroenterology 1984; 86: 436-43.","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00004836-198308000-00015","article-title":"Barrett's esophagus: inherited epithelium or inherited reflux?","volume":"5","author":"CWJr, Evehart; PG, Holtzapple; TJ, Humphries","year":"1983","unstructured":"Evehart CWJr, Holtzapple PG, Humphries TJ. Barrett's esophagus: inherited epithelium or inherited reflux? J Clin Gastroenterol 1983; 5: 357-8.","journal-title":"J Clin Gastroenterol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.7326\/0003-4819-103-1-52","article-title":"Familial gastroesophageal reflux and development of Barrett's esophagus","volume":"103","author":"Crabb, D.W.; Berk, M.A.; Hall, T.R.; Conneally, P.M.; Biegel, A.A.; Lehman, G.A.","year":"1985","unstructured":"Crabb DW, Berk MA, Hall TR, Conneally PM, Biegel AA, Lehman GA. Familial gastroesophageal reflux and development of Barrett's esophagus. Ann Intern Med 1985; 103: 52-4.","journal-title":"Ann Intern Med"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1055\/s-0028-1107777","article-title":"Begunstigt alkohol die entesthung eines Barrett-syndroms (Endobrachyosophagus)?","volume":"99","author":"Martini, G.A.; Wienbeck, M.","year":"1974","unstructured":"Martini GA, Wienbeck M. Begunstigt alkohol die entesthung eines Barrett-syndroms (Endobrachyosophagus)? Dtsch Med Wochenschr 1974; 99: 434-9.","journal-title":"Dtsch Med Wochenschr"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.31.9.964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:53:12Z","timestamp":1765691592000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.31.9.964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1990,9,1]]},"published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1136\/gut.31.9.964"],"URL":"https:\/\/doi.org\/10.1136\/gut.31.9.964","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}