{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:55:25Z","timestamp":1765648525810,"version":"3.48.0"},"reference-count":33,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:p>Six jaundiced patients with primary sclerosing cholangitis and a dominant biliary stricture were managed by endoscopic placement of endoprostheses. Five showed considerable improvement within weeks of stenting: their serum bilirubin concentration fell from mean (range) 266 mumol\/l (63-681) to 65 mumol\/l (10-280) after one month. One patient required a liver transplant at five months because of continued deterioration in hepatic function. Follow up of 12-49 months in the remaining five patients shows sustained biochemical improvement, with repeat cholangiograms indicating doubling of the minimum calibre of the extrahepatic bile duct in four patients and considerable shortening of stricture length in three. Three patients developed sepsis at the time of the initial endoprosthesis insertion: surgical drainage was necessary in one. Endoscopic methods of improving biliary-enteric drainage in jaundiced patients with primary sclerosing cholangitis may be preferable to surgical and percutaneous methods, which may complicate subsequent liver transplantation.<\/jats:p>","DOI":"10.1136\/gut.32.11.1364","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1364-1368","source":"Crossref","is-referenced-by-count":13,"title":["Improving biliary-enteric drainage in primary sclerosing cholangitis: experience with endoscopic methods."],"prefix":"10.1136","volume":"32","author":[{"given":"M","family":"Lombard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Farrant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Karani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Westaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,11,1]]},"reference":[{"key":"ref_1","first-page":"870","article-title":"Primary sclerosing cholangitis: a review of its clinical features, cholangiography and hepatic histology","volume-title":"Gut","volume":"21","author":"Chapman, R.W.G.; Arbough, B.A.M.; Rhodes, J.","year":"1980","unstructured":"Chapman RWG, Arbough BAM, Rhodes J, et al. 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Postgrad Med J 1971; 47: 666-70.","journal-title":"Postgrad Med J"},{"key":"ref_4","first-page":"1037","article-title":"Positive corticosteroid response in early primary sclerosing cholangitis","volume":"86","author":"Abstract","year":"1984","unstructured":"Burgert SL, Brown BP, Kirkpatrick RB, LeBrecque DR. Positive corticosteroid response in early primary sclerosing cholangitis [Abstract]. Gastroenterology 1984; 86: 1037.","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00000441-198606000-00008","article-title":"Case report: beneficial effect of colchicine in a case of sclerosing cholangitis","volume":"291","author":"Leiser, A.; Kadish, U.","year":"1986","unstructured":"Leiser A, Kadish U. Case report: beneficial effect of colchicine in a case of sclerosing cholangitis. 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Prednisone and colchicine are not of benefit after two years in patients with primary sclerosing cholangitis [Abstract]. Hepatology 1989; 10:638.","journal-title":"Hepatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.7326\/0003-4819-106-2-231","article-title":"Primary sclerosing cholangitis and low-dose oral pulse methotrexate therapy","volume":"106","author":"Kaplan, M.M.; Arora, S.; Pincus, S.H.","year":"1987","unstructured":"Kaplan MM, Arora S, Pincus SH. Primary sclerosing cholangitis and low-dose oral pulse methotrexate therapy. Ann Intern Med 1987; 106: 231-5.","journal-title":"Ann Intern Med"},{"key":"ref_9","first-page":"612","article-title":"Treatment of primary sclerosing cholangitis with ursodeoxycholic acid: first results of a controlled study","volume":"10","author":"Stiehl, A.; Raedsch, G.; Thielmann, L.","year":"1989","unstructured":"Stiehl A, Raedsch G, Thielmann L. 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Arch Intern Med 1987; 147: 729-31.","journal-title":"Arch Intern Med"},{"key":"ref_20","first-page":"259","article-title":"Primary sclerosing cholangitis: results of an aggressive surgical approach","volume":"1","author":"Pitt, H.A.; Thompson, H.H.; Tompkins, R.K.; Longmire, W.P.","year":"1982","unstructured":"Pitt HA, Thompson HH, Tompkins RK, Longmire WP. Primary sclerosing cholangitis: results of an aggressive surgical approach. Ann Surg 1982; 1%: 259-68.","journal-title":"Ann Surg"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0140-6736(80)91935-2","article-title":"Is sclerosing cholangitis complicating ulcerative colitis a reversible condition","volume":"ii:","author":"Wood, R.A.B.; Cuschieri, A.","year":"1980","unstructured":"Wood RAB, Cuschieri A. Is sclerosing cholangitis complicating ulcerative colitis a reversible condition. 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Radiology 1986; 159: 209-14.","journal-title":"Radiology"},{"key":"ref_24","first-page":"54","article-title":"Primary sclerosing cholangitis: biliary drainage and dilatation","volume":"74","author":"Krige, J.E.J.; Terblanche, J.; Harries-Jones, E.P.; Bornman, P.C.","year":"1987","unstructured":"Krige JEJ, Terblanche J, Harries-Jones EP, Bornman PC. Primary sclerosing cholangitis: biliary drainage and dilatation. BrJSurg 1987; 74: 54-7.","journal-title":"BrJSurg"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/gut.23.5.371","article-title":"Palliative treatment of obstructive jaundice by transpapillary introduction of large bore bile duct endoprosthesis","volume":"23","author":"Huibregtse, K.; Tytgat, G.N.","year":"1982","unstructured":"Huibregtse K, Tytgat GN. Palliative treatment of obstructive jaundice by transpapillary introduction of large bore bile duct endoprosthesis. Gut 1982; 23: 371-5.","journal-title":"Gut"},{"key":"ref_26","first-page":"78","article-title":"Therapeutic investigations in primary sclerosing cholangitis. In: Endoscopic biliary and pancreatic drainage","author":"Huibregtse, K.","year":"1988","unstructured":"Huibregtse K. Therapeutic investigations in primary sclerosing cholangitis. In: Endoscopic biliary and pancreatic drainage. Stuttgart: George Thieme Verlag, 1988: 78-85."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0016-5107(83)72540-X","article-title":"Endoscopic cholangiopancreatography: hydrostatic balloon dilatation in the bile duct and pancreas","volume":"29","author":"Siegal, J.H.; Guelrud, M.","year":"1983","unstructured":"Siegal JH, Guelrud M. Endoscopic cholangiopancreatography: hydrostatic balloon dilatation in the bile duct and pancreas. Gastrointest Endosc 1983; 29: 99-103.","journal-title":"Gastrointest Endosc"},{"key":"ref_28","first-page":"9","article-title":"Endoscopic treamtent of biliary duct strictures in sclerosing cholangitis: follow-up assessment of a new therapeutic approach","volume":"33","author":"Johnson, G.K.; Geenan, J.E.; Venu, R.P.; Hogan, W.J.","year":"1987","unstructured":"Johnson GK, Geenan JE, Venu RP, Hogan WJ. Endoscopic treamtent of biliary duct strictures in sclerosing cholangitis: follow-up assessment of a new therapeutic approach. GastrointestEndosc 1987; 33: 9-12.","journal-title":"GastrointestEndosc"},{"key":"ref_29","first-page":"598","article-title":"Early and late complications after endoscopic sphincterotomy for biliary lithiasis with and without the gall-bladder 'in-situ'","volume-title":"Gut","volume":"25","author":"Escourrou, J.; Cordova, J.A.; Lazorthes, F.; Frexinos, J.; Ribet, A.","year":"1984","unstructured":"Escourrou J, Cordova JA, Lazorthes F, Frexinos J, Ribet A. Early and late complications after endoscopic sphincterotomy for biliary lithiasis with and without the gall-bladder 'in-situ'. Gut 1984; 25: 598-602."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00004836-198702000-00018","article-title":"Short-term biliary dilatation and stenting in primary sclerosing cholangitis","volume":"9","author":"Hamilton, I.; Soutar, J.S.; Bouchier, I.A.; Cuschieri, A.","year":"1987","unstructured":"Hamilton I, Soutar JS, Bouchier IA, Cuschieri A. Short-term biliary dilatation and stenting in primary sclerosing cholangitis. J Clin Gastroenterol 1987; 9: 70-5.","journal-title":"J Clin Gastroenterol"},{"key":"ref_31","first-page":"289","article-title":"Primary sclerosing cholangitis. In: Diseases of the liver and biliary system","author":"Sherlock, S.","year":"1988","unstructured":"Sherlock S. Primary sclerosing cholangitis. In: Diseases of the liver and biliary system. 8th ed. Oxford: Blackwell Scientific, 1988: 289-300.","edition":"8th ed"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/0016-5085(87)90618-4","article-title":"Improved survival with primary sclerosing cholangitis: a review of cinicopathologic features and comparison of symptomatic and asymptomatic patients","volume":"92","author":"Helzberg, J.H.; Petersen, J.M.; Boyer, J.L.","year":"1987","unstructured":"Helzberg JH, Petersen JM, Boyer JL. Improved survival with primary sclerosing cholangitis: a review of cinicopathologic features and comparison of symptomatic and asymptomatic patients. Gastroenterology 1987; 92: 1869-75.","journal-title":"Gastroenterology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/hep.1840100406","article-title":"Primary sclerosing cholangitis: natural history, prognostic features and survival analysis","volume":"10","author":"true","year":"1989","unstructured":"Wiesner RH, Grambsch PM, Dickson DR, et al. Primary sclerosing cholangitis: natural history, prognostic features and survival analysis. 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