{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:24:07Z","timestamp":1782761047331,"version":"3.54.5"},"reference-count":26,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:p>A jejunal biopsy specimen from an asymptomatic 35 year old man was studied because of a low serum titre of reticulin antibody and the finding of coeliac disease in his son. In this specimen villous structure was quite normal as was the total number of intraepithelial lymphocytes, but the number of gamma\/delta T cell receptor bearing lymphocytes was 10 times higher than the mean in control subjects. Two years later a further biopsy specimen was obtained because of clinical symptoms and an increased titre of reticulin antibody. This specimen showed villous atrophy with crypt hyperplasia and increased infiltration of intraepithelial lymphocytes compatible with coeliac disease. A control biopsy specimen taken during gluten free diet showed normalisation of the villous architecture. Latent coeliac disease may be characterised by an increase in gamma\/delta positive cells similar to that seen in established coeliac disease.<\/jats:p>","DOI":"10.1136\/gut.32.11.1412","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1412-1414","source":"Crossref","is-referenced-by-count":143,"title":["Increase in gamma\/delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease."],"prefix":"10.1136","volume":"32","author":[{"given":"M","family":"M\u00e4ki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Collin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Savilahti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1991,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0016-5085(74)80034-X","article-title":"Latent celiac sprue","volume":"66","author":"Weinstein, W.M.","year":"1974","unstructured":"Weinstein WM. 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In discordance for coeliac disease in monozygotic twins permanent? Pediatr Res 1983; 17: 422.","journal-title":"Pediatr Res"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1651-2227.1987.tb10442.x","article-title":"Late onset coeliac disease in the monozygotic twin of a coeliac child","volume":"76","author":"de Sousa J, Salazar; de Almeida JM, Ramos; MW, Monteiro; P, Magalhaes-Ramalho","year":"1987","unstructured":"Salazar de Sousa J, Ramos de Almeida JM, Monteiro MW, Magalhaes-Ramalho P. Late onset coeliac disease in the monozygotic twin of a coeliac child. Acta Paediatr Scand 1987; 76: 172-4.","journal-title":"Acta Paediatr Scand"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0140-6736(75)92943-8","article-title":"Small-intestinal histology in coeliac disease","volume":"ii:","author":"McConnell, R.B.; Whitewell, F.","year":"1975","unstructured":"McConnell RB, Whitewell F. 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In: McConnell RB, ed. The genetics ofcoeliac disease. Lancaster: MTP Press, 1981: 235-43."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1136\/gut.22.1.65","article-title":"Early or precoeliac mucosa: development of gluten enteropathy","volume":"22","author":"B, Egan Mitchell; PF, Fottrell; B, McNicholl","year":"1981","unstructured":"Egan Mitchell B, Fottrell PF, McNicholl B. Early or precoeliac mucosa: development of gluten enteropathy. Gut 1981; 22: 65-9.","journal-title":"Gut"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/adc.62.5.465","article-title":"Decreasing incidence of coeliac disease","volume":"62","author":"Stevens, F.M.; Egan-Mitchell, B.; Cryan, E.; McCarthy, C.F.; McNicholl, B.","year":"1987","unstructured":"Stevens FM, Egan-Mitchell B, Cryan E, McCarthy CF, McNicholl B. Decreasing incidence of coeliac disease. 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Changes in clinical features of coeliac disease in adults in Edinburgh and the Lothians 1960-79. BMJ 1983; 286:95-7.","journal-title":"BMJ"},{"key":"ref_26","first-page":"245","article-title":"Keyrilainen 0. Atypical coeliac disease found with serological screening","volume":"25","year":"1990","unstructured":"Collin P, Hallstrom 0, Maki M, Viander M, Keyrilainen 0. Atypical coeliac disease found with serological screening. Scandj3 Gastroenterol 1990; 25: 245-50."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.32.11.1412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:11:28Z","timestamp":1764997888000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.32.11.1412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1991,11,1]]},"published-print":{"date-parts":[[1991,11]]}},"alternative-id":["10.1136\/gut.32.11.1412"],"URL":"https:\/\/doi.org\/10.1136\/gut.32.11.1412","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11]]}}}