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Among H pylori colonised patients, TNF alpha concentrations were significantly higher in those with active gastritis and neutrophil infiltration into the epithelium than in those with inactive gastritis. In contrast, interleukin-6 concentrations were raised in both active and inactive gastritis. This study shows that H pylori gastritis is associated with increased gastric mucosal production of TNF alpha and interleukin-6 and that the nature of the mucosal cytokine response varies with the immunohistology of the disease. Inflammatory cytokines generated locally within the gastric mucosa could be relevant to the gastric physiology of H pylori infection.<\/jats:p>","DOI":"10.1136\/gut.32.12.1473","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1473-1477","source":"Crossref","is-referenced-by-count":431,"title":["Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis."],"prefix":"10.1136","volume":"32","author":[{"given":"J E","family":"Crabtree","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T M","family":"Shallcross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R V","family":"Heatley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1991,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"i:","author":"Marshall, B.J.; Warren, JR","year":"1984","unstructured":"Marshall BJ, Warren JR. 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Immunology 1988; 64: 227-31.","journal-title":"Immunology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1128\/IAI.57.7.1916-1921.1989","article-title":"Induction of tumor necrosis factor alpha by spherules of Coccidiodes immnitis","volume":"57","author":"Slagle, D.C.; Cox, R.A.; Kuruganti, U.","year":"1989","unstructured":"Slagle DC, Cox RA, Kuruganti U. Induction of tumor necrosis factor alpha by spherules of Coccidiodes immnitis. Infect Immun 1989; 57: 1916-21.","journal-title":"Infect Immun"},{"key":"ref_26","first-page":"600","article-title":"Soluble malarial antigens are toxic and induce the production of tumor necrosis factor in vivo","volume":"66","author":"Bate, C.A.W.; Taverne, J.; Playfair, J.H.L.","year":"1989","unstructured":"Bate CAW, Taverne J, Playfair JHL. Soluble malarial antigens are toxic and induce the production of tumor necrosis factor in vivo. Immunology 1989; 66: 600-5.","journal-title":"Immunology"},{"key":"ref_27","article-title":"Conservation and diversity of Campylobacter pyloridis major antigens. Infect Immun 1987; Mucosal tumour necrosisfactor cc and interleukin-6 in patients with Helicobacter pylori associatedgastritis","author":"Perez-Perez, G.I.; Blaser, M.J.","unstructured":"Perez-Perez GI, Blaser MJ. Conservation and diversity of Campylobacter pyloridis major antigens. Infect Immun 1987; Mucosal tumour necrosisfactor cc and interleukin-6 in patients with Helicobacter pylori associatedgastritis"},{"key":"ref_28","first-page":"402","article-title":"Differential effects of LPS, IFN-y and TNF-a on the secretion of lysozyme by individual human mononuclear phagocytes: relationship to cell maturity","volume":"69","author":"Lewis, C.E.; McCarthy, S.P.; Lorenzen, J.; JO'D, McGee","year":"1990","unstructured":"Lewis CE, McCarthy SP, Lorenzen J, McGee JO'D. Differential effects of LPS, IFN-y and TNF-a on the secretion of lysozyme by individual human mononuclear phagocytes: relationship to cell maturity. Immunology 1990; 69: 402-8.","journal-title":"Immunology"},{"key":"ref_29","first-page":"3086","article-title":"Tumor necrosis factor-a up-regulates expression of secretory component, the epithelial receptor for polymeric Ig","volume":"140","author":"Kvale, D.; Lovhaug, D.; Sollid, L.M.; Brandtzaeg, P.","year":"1988","unstructured":"Kvale D, Lovhaug D, Sollid LM, Brandtzaeg P. Tumor necrosis factor-a up-regulates expression of secretory component, the epithelial receptor for polymeric Ig. J Immunol 1988; 140: 3086-9.","journal-title":"J Immunol"},{"key":"ref_30","first-page":"355","article-title":"Association between tumour necrosis factor in serum and fatal outcome in patients with meningiococcal disease","volume":"i:","author":"Waage, A.; Halstensen, A.; Espevik, T.","year":"1987","unstructured":"Waage A, Halstensen A, Espevik T. Association between tumour necrosis factor in serum and fatal outcome in patients with meningiococcal disease. Lancet 1987; i: 355-7.","journal-title":"Lancet"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1084\/jem.167.5.1743","article-title":"Tumor necrosis factor alpha in cerebrospinal fluid during bacterial but not viral meningitis","volume":"167","author":"Leist, T.P.; Frei, K.; Kam-Hansen, S.; Zinkernagel, R.M.; Fontano, A.","year":"1988","unstructured":"Leist TP, Frei K, Kam-Hansen S, Zinkernagel RM, Fontano A. Tumor necrosis factor alpha in cerebrospinal fluid during bacterial but not viral meningitis. J Exp Med 1988; 167: 1743-8.","journal-title":"J Exp Med"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/infdis\/159.2.189","article-title":"Compartmentalization of intraalveolar and systemic lipopolysaccharide-induced tumour necrosis factor and the pulmonary inflammatory response","volume":"159","author":"Nelson, S.; Bagby, G.J.; Bainton, B.G.; Wilson, L.A.; Thompson, J.J.; Summer, W.R.","year":"1989","unstructured":"Nelson S, Bagby GJ, Bainton BG, Wilson LA, Thompson JJ, Summer WR. Compartmentalization of intraalveolar and systemic lipopolysaccharide-induced tumour necrosis factor and the pulmonary inflammatory response. J Infect Dis 1989; 159: 189-94.","journal-title":"J Infect Dis"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1128\/IAI.58.7.2056-2060.1990","article-title":"Effects of anti-inflammatory agents on mucosal inflammation induced by infection with gram-negative bacteria","volume":"58","author":"Linder, H.; Engberg, I.; Van Kooten, C.; De Man, P.; SvanborgEden, C.","year":"1990","unstructured":"Linder H, Engberg I, Van Kooten C, De Man P, SvanborgEden C, Effects of anti-inflammatory agents on mucosal inflammation induced by infection with gram-negative bacteria. Infect Immun 1990; 58: 2056-60.","journal-title":"Infect Immun"},{"key":"ref_34","first-page":"229","article-title":"The role of gamma-interferon, vitamin D3 metabolites and tumor necrosis factor in the pathogenesis of tuberculosis","volume":"62","author":"Rook, G.A.W.; Taverne, J.; Leveton, C.; Steele, J.","year":"1987","unstructured":"Rook GAW, Taverne J, Leveton C, Steele J. The role of gamma-interferon, vitamin D3 metabolites and tumor necrosis factor in the pathogenesis of tuberculosis. Immunology 1987; 62: 229-34.","journal-title":"Immunology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0092-8674(86)90780-4","article-title":"Induction of, B 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation","volume":"45","author":"Kohase, M.; Henriksen-DeStefano, D.; May, L.T.; Vilcek, J.; Sehgal, P.B.","year":"1986","unstructured":"Kohase M, Henriksen-DeStefano D, May LT, Vilcek J, Sehgal PB. Induction of,B 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell 1986; 45: 659-66.","journal-title":"Cell"},{"key":"ref_36","first-page":"144","article-title":"Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells","volume":"142","author":"Jirik, F.R.; Podor, T.J.; Hirano, T.","year":"1989","unstructured":"Jirik FR, Podor TJ, Hirano T, et al. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol 1989; 142: 144-7.","journal-title":"J Immunol"},{"key":"ref_37","first-page":"35","article-title":"IL-6 inhibits lipopolysaccharideinduced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice","volume":"143","author":"Aderka, D.; Le, J.; Vilcek, J.","year":"1989","unstructured":"Aderka D, Le J, Vilcek J. IL-6 inhibits lipopolysaccharideinduced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. 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Effects of tumour necrosis factor alpha and interleukin-1 alpha and beta on human neutrophil migration, respiratory burst and degranulation. Int Arch Allergy Appl Immunol 1988; 86: 82-91.","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10621","DOI":"10.1016\/S0021-9258(18)81666-0","article-title":"Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts","volume":"264","author":"Strieter, R.M.; Phan, S.H.; Showell, H.J.","year":"1989","unstructured":"Strieter RM, Phan SH, Showell HJ, et al. Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts. 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Oxford: Blackwell Scientific, 1989:176-84."},{"key":"ref_45","first-page":"1578","article-title":"Interleukin-1 inhibits the secretion of gastric acid in rats: possible involvement of prostaglandin","volume":"3","author":"Uehara, A.; Okumura, T.; Sekiya, C.; Okamura, K.; Takasugi, Y.; Namiki, M.","year":"1989","unstructured":"Uehara A, Okumura T, Sekiya C, Okamura K, Takasugi Y, Namiki M. Interleukin-1 inhibits the secretion of gastric acid in rats: possible involvement of prostaglandin. Biochem Biophys Res Commun 1989; 3: 1578-84.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref_46","first-page":"1167","article-title":"Campylobacter pylori and duodenal ulcers: the gastrin link","volume":"i:","author":"Levi, S.; Haddad, G.; Ghosh, P.; Beardshall, K.; Playford, R.; Calam, J.","year":"1989","unstructured":"Levi S, Haddad G, Ghosh P, Beardshall K, Playford R, Calam J. Campylobacter pylori and duodenal ulcers: the gastrin link. Lancet 1989; i: 1167-8.","journal-title":"Lancet"},{"key":"ref_47","first-page":"5","article-title":"Die immunologische reaktivitat des antrums zur stimulation von verdauungsprozessen","volume-title":"klinische forrschung","author":"Teichmann, R.K.; Andress, H.J.; Gycha, S.; Siefert, J.; Brendal, W.","year":"1983","unstructured":"Teichmann RK, Andress HJ, Gycha S, Siefert J, Brendal W. Die immunologische reaktivitat des antrums zur stimulation von verdauungsprozessen. In: Schreiber HW, ed. Chirurgisches Forum fur experim und klinische forrschung. Berlin: Springer, 1983: 5-8."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.32.12.1473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T12:31:41Z","timestamp":1765629101000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.32.12.1473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1991,12,1]]},"published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1136\/gut.32.12.1473"],"URL":"https:\/\/doi.org\/10.1136\/gut.32.12.1473","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}