{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:10Z","timestamp":1787017090720,"version":"build-2736575974"},"reference-count":22,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:p>The value of positive scans of autologous 99mTc-labelled leucocytes in the detection of intestinal inflammation was assessed in 29 patients with known inflammatory bowel disease and a high probability of intestinal inflammation and 58 with a low probability of intestinal inflammation comprising 37 with intestinal symptoms and 21 with suspected abscess. Autologous leucocytes were labelled with 99mTc using either of the established methods. In patients with inflammatory bowel disease, 3\/13 with ileocaecal and 1\/11 with colonic accumulation of 99mTc were incorrectly diagnosed in that there was no histological evidence of inflammation in those regions. In the low probability patients, all 26 positive images were false positives: there were 19 in the ileocaecal and 7 in colonic regions and no differences between the two subgroups. False positives were more common in low probability than high probability patients (p = 0.011). The results were independent of the 99mTc cell labelling technique used. Three false positive patients also had normal scans for 111In-labelled granulocytes. The time of first detection of 99mTc in the bowel was earlier in true than in false positive patients (92% v 33% within 1 h, p = 0.008), the false positive rates in the first hour of imaging being 5% in high and 15% in low probability patients. In 99mTc scintigraphy, the appearance of the isotope in the intestine occurs commonly in the absence of inflammation irrespective of the cell labelling technique used. In high probability patients, imaging at 1 h can more reliably discriminate true from false positives and retain clinical usefulness. In low probability patients specificity remains unacceptable and 99mTc-labelled leucocyte scanning in these patients is of little value as a positive predictor of intestinal inflammation.<\/jats:p>","DOI":"10.1136\/gut.32.12.1502","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1502-1507","source":"Crossref","is-referenced-by-count":53,"title":["Value of positive technetium-99m leucocyte scans in predicting intestinal inflammation."],"prefix":"10.1136","volume":"32","author":[{"given":"P","family":"Gibson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lichtenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Hebbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1991,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/bmj.285.6337.255","article-title":"\"'Indium autologous leukocyte scanning: comparison with radiology for imaging the colon in inflammatory bowel disease","volume":"285","author":"Saverymuttu, S.H.; Peters, A.M.; Hodgson, H.J.F.; Chadwick, V.S.; Lavender, J.P.","year":"1982","unstructured":"Saverymuttu SH, Peters AM, Hodgson HJF, Chadwick VS, Lavender JP. \"'Indium autologous leukocyte scanning: comparison with radiology for imaging the colon in inflammatory bowel disease. 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Gastroenterology 1986; 90: 1121-8."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/0016-5085(87)90447-1","article-title":"Early and delayed Indium-I II leukocyte imaging in Crohn's disease","volume":"93","author":"Navab, F.; Boyd, C.M.; Diner, W.C.; Subramani, R.; Cahn, C.","year":"1987","unstructured":"Navab F, Boyd CM, Diner WC, Subramani R, Cahn C. Early and delayed Indium-I II leukocyte imaging in Crohn's disease. Gastroenterology 1987; 93: 829-34.","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0002-9610(80)90237-8","article-title":"Indium-1Il labelled leucocytes in the evaluation of suspected abdominal abscesses","volume":"139","author":"Coleman, R.E.; Black, R.E.; Welch, D.M.; Maxwell, J.G.","year":"1980","unstructured":"Coleman RE, Black RE, Welch DM, Maxwell JG. Indium-1Il labelled leucocytes in the evaluation of suspected abdominal abscesses. 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Gastroenterology 1983; 85","author":"Saverymuttu, S.H.; Peters, A.M.; Lavender, J.P.; Pepys, M.B.; Hodgson, H.J.F.; Chadwick, V.S.","unstructured":"Saverymuttu SH, Peters AM, Lavender JP, Pepys MB, Hodgson HJF, Chadwick VS. Quantitative fecal indium111 labelled leukocyte excretion in the assessment of disease activity in Crohn's disease. Gastroenterology 1983; 85: 1333-9."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/gut.26.9.955","article-title":"111-Indium granulocytes in the detection of inflammatory bowel disease","volume":"26","author":"Saverymuttu, S.H.; Peters, A.M.; Crofton, M.E.","year":"1985","unstructured":"Saverymuttu SH, Peters AM, Crofton ME, et al. 111-Indium granulocytes in the detection of inflammatory bowel disease. Gut 1985; 26:955-60.","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/bmj.293.6540.171","article-title":"Technetium-99m autologous phagocyte scanning: a new imaging technique for inflammatory bowel disease","volume":"293","author":"Pullman, W.; Hanna, R.; Sullivan, P.; Booth, J.A.; Lomas, F.; Doe, W.F.","year":"1986","unstructured":"Pullman W, Hanna R, Sullivan P, Booth JA, Lomas F, Doe WF. Technetium-99m autologous phagocyte scanning: a new imaging technique for inflammatory bowel disease. BMJ 1986; 293: 171-4.","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1440-1746.1986.tb00126.x","article-title":"Assessment of disease activity and localization in inflammatory bowel disease using \"\"Tc-labelled leucocytes","volume":"1","author":"Bartholomeusz, D.L.; Shearman, D.J.C.; Chatterton, B.E.","year":"1986","unstructured":"Bartholomeusz DL, Shearman DJC, Chatterton BE, et al. Assessment of disease activity and localization in inflammatory bowel disease using \"\"Tc-labelled leucocytes. J Gastroenter Hepatol 1986; 1: 297-303.","journal-title":"J Gastroenter Hepatol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0016-5085(88)90174-6","article-title":"Assessment of inflammatory bowel disease activity by technetium-99m phagocyte scanning","volume":"95","author":"Pullman, W.E.; Sullivan, P.J.; Barratt, P.J.; Lising, J.; Booth, J.A.; Doe, W.F.","year":"1988","unstructured":"Pullman WE, Sullivan PJ, Barratt PJ, Lising J, Booth JA, Doe WF. Assessment of inflammatory bowel disease activity by technetium-99m phagocyte scanning. 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Nucl Med Commun 1988; 9:435-7.","journal-title":"Nucl Med Commun"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00006231-198806000-00009","article-title":"\"Tc--HMPAO labelled leucocytes: comparison with \"'In-tropolonate labelled granulocytes","volume":"9","author":"Peters, A.M.; Roddie, M.E.; Danpure, H.J.","year":"1988","unstructured":"Peters AM, Roddie ME, Danpure HJ, et al. \"Tc--HMPAO labelled leucocytes: comparison with \"'In-tropolonate labelled granulocytes. Nucl Med Commun 1988; 9: 449-63.","journal-title":"Nucl Med Commun"},{"key":"ref_18","first-page":"311","article-title":"Comparison of technetium-99m-HMPAO leukocytes with indium-11-oxine leukocytes for localizing intraabdominal sepsis","volume":"31","author":"Mountford, P.J.; Kettle, A.G.; O'Doherty, M.J.; Coakley, A.J.","year":"1990","unstructured":"Mountford PJ, Kettle AG, O'Doherty MJ, Coakley AJ. Comparison of technetium-99m-HMPAO leukocytes with indium-11-oxine leukocytes for localizing intraabdominal sepsis. J Nucl Med 1990; 31: 311-5.","journal-title":"J Nucl Med"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00006231-198810000-00009","article-title":"White cells radiolabelled with \"'In and FTc' - a study of relative sensitivity and in vivo viability","volume":"9","author":"Costa, D.C.; Lui, D.; Ell, P.J.","year":"1988","unstructured":"Costa DC, Lui D, Ell PJ. White cells radiolabelled with \"'In and FTc' - a study of relative sensitivity and in vivo viability. Nucl Med Commun 1988; 9: 725-31.","journal-title":"Nucl Med Commun"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/gut.29.4.516","article-title":"Ulcerative colitis - a disease characterised by the abnormal colonic epithelial cell?","volume":"29","author":"Gibson, P.R.; Van de Pol, E.; Barratt, P.J.; Doe, W.F.","year":"1988","unstructured":"Gibson PR, Van de Pol E, Barratt PJ, Doe WF. Ulcerative colitis - a disease characterised by the abnormal colonic epithelial cell? Gut 1988; 29: 516-21.","journal-title":"Gut"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/BF00448542","article-title":"Radiochemistry and biostability of autologous leucocytes labelled with \"'Tcstannous colloid in whole blood","volume":"9","author":"Hanna, R.; Braun, T.; Levendel, A.; Lomas, F.","year":"1984","unstructured":"Hanna R, Braun T, Levendel A, Lomas F. Radiochemistry and biostability of autologous leucocytes labelled with \"'Tcstannous colloid in whole blood. Eur J Nucl Med 1984; 9: 216-9.","journal-title":"Eur J Nucl Med"},{"key":"ref_22","first-page":"1014","article-title":"Indium\"'-labelled autologous leucocytes in man","volume":"18","author":"Thakur, M.L.; Lavender, J.P.; Arnot, R.N.; Silvester, D.J.; Segal, A.W.","year":"1977","unstructured":"Thakur ML, Lavender JP, Arnot RN, Silvester DJ, Segal AW. Indium\"'-labelled autologous leucocytes in man. J Nucl Med 1977; 18: 1014-21.","journal-title":"J Nucl Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.32.12.1502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:07:32Z","timestamp":1765606052000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.32.12.1502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":22,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1991,12,1]]},"published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1136\/gut.32.12.1502"],"URL":"https:\/\/doi.org\/10.1136\/gut.32.12.1502","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}