{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:23:14Z","timestamp":1791069794383,"version":"4.1.0"},"reference-count":18,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:p>To determine the prognostic importance of microscopic rectal inflammation we followed up 82 patients (aged 21 to 78 years, 44 men) with chronic quiescent ulcerative colitis over 12 months. At trial entry each patient underwent a rectal biopsy and sections were graded independently by two histopathologists. A chronic inflammatory cell infiltrate of varying severity was present in all biopsy specimens, and 58% had crypt architectural irregularities. In addition, 32% had evidence of acute inflammatory activity: 28% acute inflammatory cell infiltrate, 11% crypt abscesses, and 22% mucin depletion. Agreement between the two histopathologists for the presence of each of these features was 94% (90-98%). During the 12 month follow up 27 patients (33%) relapsed after a mean interval of 18 weeks (range 3-44 weeks). Relapse rates were unrelated to duration or extent of disease or to the type of maintenance drug treatment. In patients with an acute inflammatory cell infiltrate 52% relapsed, whereas in the absence of such an infiltrate only 25% relapsed (p = 0.02). Similarly, relapse rates were higher in the presence of crypt abscesses (78% v 27%, p less than 0.005), mucin depletion (56% v p less than 0.02), and breaches in the surface epithelium (75% v 31%, p = 0.1). The presence of a chronic inflammatory cell infiltrate or crypt architectural irregularities, however, bore no relation to the frequency of colitis relapse.<\/jats:p>","DOI":"10.1136\/gut.32.2.174","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"174-178","source":"Crossref","is-referenced-by-count":454,"title":["Microscopic activity in ulcerative colitis: what does it mean?"],"prefix":"10.1136","volume":"32","author":[{"given":"S A","family":"Riley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Dutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Herd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1991,2,1]]},"reference":[{"key":"ref_1","first-page":"691","article-title":"Clinical experience with suction biopsy of the rectal mucosa","volume":"42","author":"Flick, A.L.; Voegtlin, K.F.; Rubin, C.E.","year":"1972","unstructured":"Flick AL, Voegtlin KF, Rubin CE. Clinical experience with suction biopsy of the rectal mucosa. Gastroenterology 1972; 42:691-705.","journal-title":"Gastroenterology"},{"key":"ref_2","first-page":"1315","article-title":"Biopsy studies in ulcerative colitis","volume":"i:","author":"Truelove, S.C.; Richards, W.C.D.","year":"1956","unstructured":"Truelove SC, Richards WCD. Biopsy studies in ulcerative colitis. BrMedj 1956; i: 1315-8.","journal-title":"BrMedj"},{"issue":"30","key":"ref_3","first-page":"393","article-title":"The value of rectal biopsy in the diagnosis of ulcerative colitis","volume":"1961","author":"Matts, S.G.F.","unstructured":"Matts SGF. The value of rectal biopsy in the diagnosis of ulcerative colitis. QJMed 1961; 30: 393-407.","journal-title":"QJMed"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF01296733","article-title":"Correlations between defined sigmoidoscopic appearances and other measures of disease activity in ulcerative colitis","volume":"27","author":"Powell-Truck, J.; Day, D.W.; Buckell, N.A.; Wadsworth, J.; Lennard-Jones, J.E.","year":"1982","unstructured":"Powell-Truck J, Day DW, Buckell NA, Wadsworth J, Lennard-Jones JE. Correlations between defined sigmoidoscopic appearances and other measures of disease activity in ulcerative colitis. Dig Dis Sci 1982; 27: 533-7.","journal-title":"Dig Dis Sci"},{"key":"ref_5","first-page":"365","article-title":"Responses to drug therapy in ulcerative colitis","volume":"64","author":"Korelitz, B.I.; Sommers, S.C.","year":"1975","unstructured":"Korelitz BI, Sommers SC. Responses to drug therapy in ulcerative colitis. 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Oxford: Blackwell Scientific, 1972: 458-75."},{"key":"ref_8","first-page":"114","article-title":"The role ofsigmoidoscopy and rectal biopsy in diagnosis and management of inflammatory bowel disease: personal experience","volume":"83","author":"Fochios, D.E.; Korelitz, B.I.","year":"1988","unstructured":"Fochios DE, Korelitz BI. The role ofsigmoidoscopy and rectal biopsy in diagnosis and management of inflammatory bowel disease: personal experience. Am J Gastroenterology 1988; 83: 114-9.","journal-title":"Am J Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/gut.7.3.288","article-title":"Sigmoidoscopy and cytology in the detection of microscopic disease of the rectal mucosa in ulcerative colitis","volume":"7","author":"Watts, J.M.; Thompson, H.; Goligher, J.C.","year":"1966","unstructured":"Watts JM, Thompson H, Goligher JC. Sigmoidoscopy and cytology in the detection of microscopic disease of the rectal mucosa in ulcerative colitis. 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