{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:33:53Z","timestamp":1791218033706,"version":"4.1.0"},"reference-count":16,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:p>We have previously shown that infusion of triglycerides and long chain fatty acids into the ileum of humans and rats delays small bowel transit time. The present studies have investigated the effect on the stomach to caecum transit time of a baked bean meal of the ileal infusion of 20 mM, 50 mM, and 100 mM acetic, butyric, hexenoic, and caprylic acids in rats. After an 18 hour fast either a control or a short chain fatty acid (SCFA) solution (pH 6.5) was infused into the ileum for 30 minutes (0.3 ml\/hour). A test meal was given by gavage and the infusion continued for a further 150 minutes. The arrival of the meal in the colon was signalled by a rise in the exhaled hydrogen concentration. Acetic acid (20 mM, 50 mM, 100 mM), butyric acid (100 mM), and caprylic acid (100 mM) produced a significant acceleration of transit which was inversely proportional to SCFA chain length. In a separate experiment, infusion of 100 mM acetic acid, the most potent SCFA, into an isolated ileal Thirty-Vella loop failed to accelerate transit of the test meal. Our results suggest that SCFAs accelerate transit via a local enteric reflex.<\/jats:p>","DOI":"10.1136\/gut.32.3.266","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"266-269","source":"Crossref","is-referenced-by-count":34,"title":["Short chain fatty acids in the terminal ileum accelerate stomach to caecum transit time in the rat."],"prefix":"10.1136","volume":"32","author":[{"given":"A","family":"Richardson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A T","family":"Delbridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N J","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R D","family":"Rumsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N W","family":"Read","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1991,3,1]]},"reference":[{"key":"ref_1","first-page":"401","article-title":"Cunningham KM, Read NW. Regulation of gastric emptying by ileal","volume-title":"nutrients in humans. Gastroenterology 1988; 94","author":"Welch, I.M.","unstructured":"Welch IM, Cunningham KM, Read NW. Regulation of gastric emptying by ileal nutrients in humans. Gastroenterology 1988; 94: 401-4."},{"key":"ref_2","first-page":"274","article-title":"Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels","volume-title":"of neurotensin and enteroglucagon. Gastroenterology","volume":"86","author":"Read, N.W.; McFarlane, A.; Kinsman, R.I.","year":"1984","unstructured":"Read NW, McFarlane A, Kinsman RI, et al. Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology 1984; 86: 274-80."},{"key":"ref_3","first-page":"1005","article-title":"Holgate AM, Read NW. Effect of ileal infusion of Intralipid on gastrointestinal transit, ileal flow rate and carbohydrate absorption in humans after ingestion of","volume-title":"a liquid meal. Gastroenterology 1985; 86","unstructured":"Holgate AM, Read NW. Effect of ileal infusion of Intralipid on gastrointestinal transit, ileal flow rate and carbohydrate absorption in humans after ingestion of a liquid meal. Gastroenterology 1985; 86: 1005-11."},{"key":"ref_4","first-page":"265","article-title":"The ileal brakeinhibition of jejunal motility after ileal perfusion in man","volume":"25","author":"Spiller, R.C.; Trotman, R.F.; Higgins, B.E.","year":"1984","unstructured":"Spiller RC, Trotman RF, Higgins BE, et al. The ileal brakeinhibition of jejunal motility after ileal perfusion in man. 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J Physiol (Lond)"},{"issue":"4","key":"ref_7","first-page":"427","article-title":"Short chain fatty acids stimulate motility of the canine ileum","volume":"253","author":"Kamath, P.S.; Hoepfner, M.T.; Phillips, S.F.","year":"1987","unstructured":"Kamath PS, Hoepfner MT, Phillips SF. Short chain fatty acids stimulate motility of the canine ileum. Am J Physiol 1987; 253 (4) Pt 1: G427-33.","journal-title":"Am J Physiol"},{"key":"ref_8","first-page":"1496","article-title":"Short chain fatty acids stimulate ileal motility","volume-title":"humans. Gastroenterology 1988; 95","author":"Kamath, P.S.; Phillips, S.F.; Zinsmeister, A.R.","unstructured":"Kamath PS, Phillips SF, Zinsmeister AR. Short chain fatty acids stimulate ileal motility in humans. Gastroenterology 1988; 95: 1496-502."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/gut.28.7.849","article-title":"Rumsey RDE, Read NW. 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Contractile patterns and transit of fluid in canine terminal ileum. AmJ Physiol 1985; 249: G264-70.","journal-title":"AmJ Physiol"},{"key":"ref_12","first-page":"1232","article-title":"ECA independent \"giant migrating contractions\"","volume-title":"of small intestine. Gastroenterology","volume":"86","author":"Sarna, S.K.","year":"1984","unstructured":"Sarna SK. ECA independent \"giant migrating contractions\" of small intestine. Gastroenterology 1984; 86: 1232."},{"key":"ref_13","first-page":"39","article-title":"Partition and absorption of volatile fatty acids in the alimentary canal of the rat. Anneales de Recherches Veterinaires","volume":"7","author":"Remesy, C.; Demigne, C.","year":"1976","unstructured":"Remesy C, Demigne C. Partition and absorption of volatile fatty acids in the alimentary canal of the rat. 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