{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:55:09Z","timestamp":1781913309884,"version":"3.54.5"},"reference-count":22,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:p>This study was designed to determine the extent of pancreatic insufficiency in untreated coeliac disease and whether pancreatic secretion is impaired after a prolonged gluten free period. Three groups of patients were studied: group A comprised 44 patients, mean (SD) age 4.0 (3.1) years, with coeliac disease and total or subtotal atrophy of the intestinal mucosa; group B comprised 67 patients, mean age 4.4 (3.0) years, with coeliac disease but with normal morphology of the intestinal villi (after 12.9 months of a gluten free diet); group C comprised 49 control subjects, mean age 3.2 (3.0) years, with normal jejunal histology. In all subjects exocrine pancreatic function was determined by the secretin-caerulein test; bicarbonate concentration and lipase, phospholipase, and chymotrypsin activity were measured after an intravenous injection of secretin 1 clinical unit (CU) + caerulein 75 ng\/kg body weight. Faecal chymotrypsin concentration was also assayed. No significant difference was found between values of the duodenal output of pancreatic enzymes and bicarbonate obtained in the three groups; however, 10 of 44 untreated coeliac patients showed tryptic or lipolytic activity, or both, below the normal limit for our laboratory. The mean value of the faecal chymotrypsin concentration was significantly lower in untreated than in treated coeliac patients (p less than 0.0001) or in control subjects (p less than 0.0001). It is concluded that untreated coeliac patients may have pancreatic deficiency independent of a decrease in enterohormone release. No primary or secondary pancreatic insufficiency was found in coeliac patients where the intestinal mucosa had returned to normal.<\/jats:p>","DOI":"10.1136\/gut.32.7.796","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"796-799","source":"Crossref","is-referenced-by-count":71,"title":["Exocrine pancreatic function in children with coeliac disease before and after a gluten free diet."],"prefix":"10.1136","volume":"32","author":[{"given":"A","family":"Carroccio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Iacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Montalto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Cavataio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Di Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Balsamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Notarbartolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1991,7,1]]},"reference":[{"issue":"53","key":"ref_1","first-page":"464","article-title":"Exocrine pancreas insufficiency secondary to gluten enteropathy","volume":"1960","author":"Fernanez, L.B.; De Paula, A.; Prizont, R.","unstructured":"Fernanez LB, De Paula A, Prizont R. Exocrine pancreas insufficiency secondary to gluten enteropathy. AmJ Gastroenterol 1960; 53: 464-9.","journal-title":"AmJ Gastroenterol"},{"key":"ref_2","first-page":"243","article-title":"The pancreatic secretion in the malabsorption syndrome and related malnutrition states","volume":"24","author":"Dreiling, D.A.","year":"1957","unstructured":"Dreiling DA. The pancreatic secretion in the malabsorption syndrome and related malnutrition states. Journal of the Mount Sinai Hospital 1957; 24: 243-50.","journal-title":"Journal of the Mount Sinai Hospital"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3109\/00365527709181345","article-title":"Time-related enzyme concentrations in duodenal aspirates after ingestion of a test meal","volume":"12","author":"Ihse, I.; Lilia, P.; Evander, A.; Skude, G.","year":"1977","unstructured":"Ihse I, Lilia P, Evander A, Skude G. Time-related enzyme concentrations in duodenal aspirates after ingestion of a test meal. ScandJ Gastroenterol 1977; 12: 629-35.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_4","first-page":"25","article-title":"Impaired cholecystokinin-pancreozymin secretion, intraluminal dilution, and maldigestion","volume-title":"of fat in sprue. Gastroenterology 1972; 63","author":"Di Magno EP, Go VLW, Summerskill WHJ","unstructured":"Di Magno EP, Go VLW, Summerskill WHJ. Impaired cholecystokinin-pancreozymin secretion, intraluminal dilution, and maldigestion of fat in sprue. Gastroenterology 1972; 63: 25-32."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/00365526709180051","article-title":"pH and concentration of pancreatic enzymes in aspirates from the human duodenum during digestion of a standard meal in patients with intestinal disorders","volume":"2","author":"Worning, H.; Mullerty, S.; Hess Thaysen, E.; Bang, H.O.","year":"1967","unstructured":"Worning H, Mullerty S, Hess Thaysen E, Bang HO. pH and concentration of pancreatic enzymes in aspirates from the human duodenum during digestion of a standard meal in patients with intestinal disorders. Scand Jf Gastroenterol 1967; 2: 81-9.","journal-title":"Scand Jf Gastroenterol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0016-5085(80)90860-4","article-title":"Exocrine pancreatic insufficiency in celiac sprue: cause of treatment failure","volume":"78","author":"Regan, P.J.; Di Magno, E.P.","year":"1980","unstructured":"Regan PJ, Di Magno EP. Exocrine pancreatic insufficiency in celiac sprue: cause of treatment failure. Gastroenterology 1980; 78: 484-7.","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0016-5085(85)90497-4","article-title":"Defective gallbladder emptying and cholecystokinin release in celiac disease","volume":"88","author":"Maton, P.N.; Selden, A.C.; Fitzpatrick, M.L.; Chadwick, U.S.","year":"1985","unstructured":"Maton PN, Selden AC, Fitzpatrick ML, Chadwick US. Defective gallbladder emptying and cholecystokinin release in celiac disease. Gastroenterology 1985; 88: 391-6.","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1172\/JCI110433","article-title":"Identification and measurement ofmolecular variants ofcholecystokinin in duodenal mucosa and plasma","volume":"69","author":"Calam, J.; Ellis, A.; Dockray, G.J.","year":"1982","unstructured":"Calam J, Ellis A, Dockray GJ. Identification and measurement ofmolecular variants ofcholecystokinin in duodenal mucosa and plasma.J Clin Invest 1982; 69: 218-25.","journal-title":"J Clin Invest"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/BF01079794","article-title":"Impairment of secretin release in celiac sprue","volume":"23","author":"Rhodes, R.A.; Tai, H.H.; Chey, W.Y.","year":"1978","unstructured":"Rhodes RA, Tai HH, Chey WY. Impairment of secretin release in celiac sprue. Dig Dis Sci 1978; 23: 833-9.","journal-title":"Dig Dis Sci"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3109\/00365528309182092","article-title":"Secretin release in coeliac disease","volume":"18","author":"Kilander, A.F.; Hanssen, L.E.; Gilberg, R.E.","year":"1983","unstructured":"Kilander AF, Hanssen LE, Gilberg RE. Secretin release in coeliac disease. ScandJ Gastroenterol 1983; 18: 765-9.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_11","first-page":"77","article-title":"The exocrine pancreas and protein-calorie malnutrition","volume":"42","author":"Barbezat, G.O.; Hansen, J.D.L.","year":"1968","unstructured":"Barbezat GO, Hansen JDL. The exocrine pancreas and protein-calorie malnutrition. Pediatrics 1968; 42: 77-92.","journal-title":"Pediatrics"},{"key":"ref_12","first-page":"785","article-title":"Gut-hormone profile in coeliac disease","volume":"i:","author":"Bestermann, H.S.; Sarson, D.L.; Johnston, D.I.","year":"1978","unstructured":"Bestermann HS, Sarson DL, Johnston DI, et al. Gut-hormone profile in coeliac disease. Lancet 1978; i: 785-8.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00006676-198603000-00006","article-title":"Endocrine and exocrine pancreatic function in treated coeliac disease","volume":"1","author":"Collins, B.J.; Bell, P.M.; Boyd, S.","year":"1986","unstructured":"Collins BJ, Bell PM, Boyd S, et al. Endocrine and exocrine pancreatic function in treated coeliac disease. Pancreas 1986; 1: 143-7.","journal-title":"Pancreas"},{"key":"ref_14","first-page":"391","article-title":"A new photometric method for the determination of chymotrypsin in stool","volume":"311","author":"Kaspar, P.; Moller, G.; Wahlefeld, A.W.; Staehler, F.","year":"1982","unstructured":"Kaspar P, Moller G, Wahlefeld AW, Staehler F. A new photometric method for the determination of chymotrypsin in stool. ZAnal Chem 1982; 311: 391-2.","journal-title":"ZAnal Chem"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000197914","article-title":"Investigation of exocrine pancreatic function by continuous infusion of cerulein and secretin in normal subjects and in chronic pancreatitis","volume":"14","author":"Gullo, L.; Costa, P.L.; Fontana, G.; Labo', G.","year":"1976","unstructured":"Gullo L, Costa PL, Fontana G, Labo' G. Investigation of exocrine pancreatic function by continuous infusion of cerulein and secretin in normal subjects and in chronic pancreatitis. Digestion 1976; 14: 97-107.","journal-title":"Digestion"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1136\/gut.24.7.680","article-title":"Single intubation test for investigation of malabsorption and diarrhoea","volume":"24","author":"Taylor, R.H.; Waterman, S.","year":"1983","unstructured":"Taylor RH, Waterman S. Single intubation test for investigation of malabsorption and diarrhoea. Gut 1983; 24: 680-2.","journal-title":"Gut"},{"key":"ref_17","first-page":"706","article-title":"Dosage de la lipase dans le suc duodenal","volume":"8","author":"Sarles, H.; Taulier, J.; Figarella, C.","year":"1963","unstructured":"Sarles H, Taulier J, Figarella C. Dosage de la lipase dans le suc duodenal. Revue Franfaises Etudes Clinique et Biologie 1963; 8: 706-7.","journal-title":"Revue Franfaises Etudes Clinique et Biologie"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/00365527109180682","article-title":"The assay of human pancreatic phospholipase in pancreatic juice and duodenal contents","volume":"6","author":"Figarella, C.; Ribeiro, T.","year":"1971","unstructured":"Figarella C, Ribeiro T. The assay of human pancreatic phospholipase in pancreatic juice and duodenal contents. ScandJ Gastroenterol 1971; 6: 133-7.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_19","first-page":"493","article-title":"Problemes poses par le dosage des enzymes pancreatiques dans le suc duodenal","volume":"47","author":"true","year":"1966","unstructured":"Figarella C, Souville C, Quet 0, et al. Problemes poses par le dosage des enzymes pancreatiques dans le suc duodenal. Vie Medicale 1966; 47: 493-500.","journal-title":"Vie Medicale"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF01320311","article-title":"Exocrine pancreatic function of children from the Ivory Coast compared to French children. Effect of kwashiorkor","volume":"31","author":"Sauniere, J.F.; Sarles, H.; Attia, Y.","year":"1986","unstructured":"Sauniere JF, Sarles H, Attia Y, et al. Exocrine pancreatic function of children from the Ivory Coast compared to French children. Effect of kwashiorkor. Dig Dis Sci 1986; 31: 481-6.","journal-title":"Dig Dis Sci"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1056\/NEJM197304192881603","article-title":"Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency","volume":"288","author":"Di Magno EP, Go VLW, Summerskill WHJ","year":"1973","unstructured":"Di Magno EP, Go VLW, Summerskill WHJ. Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engi Jf Med 1973; 288: 813-5.","journal-title":"N Engi Jf Med"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/gut.23.9.777","article-title":"Exocrine pancreatic function tests","volume":"23","author":"Lanskish, P.G.","year":"1982","unstructured":"Lanskish PG. Exocrine pancreatic function tests. Gut 1982; 23: 777-98.","journal-title":"Gut"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.32.7.796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:03:53Z","timestamp":1765605833000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.32.7.796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1991,7,1]]},"published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1136\/gut.32.7.796"],"URL":"https:\/\/doi.org\/10.1136\/gut.32.7.796","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}