{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:46:17Z","timestamp":1773791177567,"version":"3.50.1"},"reference-count":25,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1991,8,1]]},"DOI":"10.1136\/gut.32.8.900","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:41:31Z","timestamp":1190151691000},"page":"900-904","source":"Crossref","is-referenced-by-count":18,"title":["Carcinoma and DNA aneuploidy in Crohn's colitis--a histological and flow cytometric study."],"prefix":"10.1136","volume":"32","author":[{"given":"R","family":"Lofberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Brostrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Karlen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Tribukait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"1099","volume":"289","author":"Weedon, D.D.; Shorter, R.G.; Ilstrup, D.M.; Huizenga, K.A.; Taylor, W.F.","year":"1973","unstructured":"Weedon DD, Shorter RG, Ilstrup DM, Huizenga KA, Taylor WF. Crohn's disease and cancer. N Englj Med 1973; 289: 1099-104.","journal-title":"Crohn's disease and cancer. N Englj Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gut.21.12.1024","article-title":"Malignancy in Crohn's disease","volume":"21","author":"Gyde, S.N.; Prior, P.; Macartney, J.C.; Thompson, H.; Waterhouse, J.A.H.; Allan, R.N.","year":"1980","unstructured":"Gyde SN, Prior P, Macartney JC, Thompson H, Waterhouse JAH, Allan RN. Malignancy in Crohn's disease. Gut 1980; 21: 1024-9.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1002\/1097-0142(19811215)48:12<2742::AID-CNCR2820481231>3.0.CO;2-P","article-title":"Aufses AH. A comparison of cancer risk in Crohn's disease and ulcerative colitis","volume":"48","author":"Greenstein, A.J.; Sachar, D.B.; Smith, H.; Janowitz, H.D.","year":"1981","unstructured":"Greenstein AJ, Sachar DB, Smith H, Janowitz HD, Aufses AH. A comparison of cancer risk in Crohn's disease and ulcerative colitis. Cancer 1981; 48: 2742-5.","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/00365528609034627","article-title":"Malignancy in Crohn's disease","volume":"21","author":"true","year":"1986","unstructured":"Quist N, Jacobsen 0, N0rgaard P, et al. Malignancy in Crohn's disease. Scandj Gastroenterol 1986; 21: 82-6.","journal-title":"Scandj Gastroenterol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3109\/00365528909093058","article-title":"Intestinal cancer in patients with Crohn's disease. A population study in central Israel","volume":"24","author":"Fireman, Z.; Grossman, A.; Lilos, P.","year":"1989","unstructured":"Fireman Z, Grossman A, Lilos P, et al. Intestinal cancer in patients with Crohn's disease. A population study in central Israel. Scandj Gastroenterol 1989; 24: 346-50.","journal-title":"Scandj Gastroenterol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/gut.29.1.49","article-title":"Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982","volume":"29","year":"1988","unstructured":"Gollop JH, Phillips SF, Melton III LJ, Zinsmeister AR. Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982. Gut 1988; 29: 49-56.","journal-title":"Gut"},{"key":"ref_7","first-page":"578","article-title":"Colonic 'precancer'","volume-title":"Crohn's disease. Gastroenterology 1981; 80","author":"Craft, C.F.; Mendelsohn, G.; Cooper, H.S.; Yardley, J.H.","unstructured":"Craft CF, Mendelsohn G, Cooper HS, Yardley JH. Colonic 'precancer' in Crohn's disease. Gastroenterology 1981; 80: 578-84."},{"key":"ref_8","first-page":"492","article-title":"The histological appearance of dysplasia (precarcinomatous change) in Crohn's disease of the small","volume-title":"and large intestine. Gastroenterology 1981; 81","author":"Simpson, S.; Traube, J.; Riddell, R.H.","unstructured":"Simpson S, Traube J, Riddell RH. The histological appearance of dysplasia (precarcinomatous change) in Crohn's disease of the small and large intestine. Gastroenterology 1981; 81:492-501."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0016-5085(85)90343-9","article-title":"Colorectal carcinomas in patients with Crohn's disease","volume":"89","author":"Hamilton, SR","year":"1985","unstructured":"Hamilton SR. Colorectal carcinomas in patients with Crohn's disease. Gastroenterology 1985; 89: 398-407.","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"130714","DOI":"10.1016\/0016-5085(87)90260-5","article-title":"Mir-Madilessi SH, Farmer RG. Crohn's disease and intestinal carcinoma","volume":"93","author":"Petras, R.E.","year":"1987","unstructured":"Petras RE, Mir-Madilessi SH, Farmer RG. Crohn's disease and intestinal carcinoma. Gastroenterology 1987; 93: 130714.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/00004836-198708000-00019","article-title":"High grade dysplasia in Crohn's colitis characterized by flow cytometry","volume":"9","author":"McKinley, M.J.; Budman, D.R.; Kahn, E.","year":"1987","unstructured":"McKinley MJ, Budman DR, Kahn E. High grade dysplasia in Crohn's colitis characterized by flow cytometry. J Clin Gastroenterol 1987; 9: 452-5.","journal-title":"J Clin Gastroenterol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/1097-0142(19840115)53:2<291::AID-CNCR2820530218>3.0.CO;2-B","article-title":"Early detection of malignancy in ulcerative colitis. A flow cytometric DNAstudy","volume":"53","author":"Hammarberg, C.; Slezak, P.; Tribukait, B.","year":"1984","unstructured":"Hammarberg C, Slezak P, Tribukait B. Early detection of malignancy in ulcerative colitis. A flow cytometric DNAstudy. Cancer 1984; 53: 291-5.","journal-title":"Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1136\/gut.28.9.1100","article-title":"Flow cytometric DNA-analysis in longstanding ulcerative colitis: a method of prediction of dysplasia and carcinoma development?","volume":"28","year":"1987","unstructured":"Lofberg R, Tribukait B. Ost A, Brostrom 0, Reichard H. Flow cytometric DNA-analysis in longstanding ulcerative colitis: a method of prediction of dysplasia and carcinoma development? Gut 1987; 28: 1100-6.","journal-title":"Gut"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S0016-5085(88)80013-1","article-title":"Dysplasia and deoxyribonucleic acid aneuploidy in the assessment of precancerous changes in chronic ulcerative colitis","volume":"95","author":"Melville, D.M.; Jass, JR, Shepherd; N.A.","year":"1988","unstructured":"Melville DM, Jass JR, Shepherd NA, et al. Dysplasia and deoxyribonucleic acid aneuploidy in the assessment of precancerous changes in chronic ulcerative colitis. Gastroenterology 1988; 95: 668-75.","journal-title":"Gastroenterology"},{"key":"ref_15","first-page":"206","article-title":"Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres","volume-title":"Gut","volume":"29","author":"Gyde, S.N.; Prior, P.; Allan, R.N.","year":"1988","unstructured":"Gyde SN, Prior P, Allan RN, et al. Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres. Gut 1988; 29: 206-17."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0016-5085(90)90622-8","article-title":"Colonoscopic surveillance in longstanding total ulcerative colitis - a fifteen year follow-up study","volume":"99","year":"1990","unstructured":"Lofberg R, Brostrom 0, Karlen P, Tribukait B, Ost A. Colonoscopic surveillance in longstanding total ulcerative colitis - a fifteen year follow-up study. Gastroenterology 1990; 99: 1021-31.","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0016-5085(87)90856-0","article-title":"Colonoscopy in inflammatory bowel disease. Diagnostic accuracy and proposal of an endoscopic score","volume":"92","author":"Pera, A.; Bellando, P.; Caldera, D.","year":"1987","unstructured":"Pera A, Bellando P, Caldera D, et al. Colonoscopy in inflammatory bowel disease. Diagnostic accuracy and proposal of an endoscopic score. Gastroenterology 1987; 92: 181-5.","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0046-8177(83)80175-0","article-title":"Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications","volume":"14","author":"Riddell, R.H.; Goldman, H.; Ransohoff, D.","year":"1983","unstructured":"Riddell RH, Goldman H, Ransohoff D, et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 1983; 14: 931-66.","journal-title":"Hum Pathol"},{"key":"ref_19","first-page":"151","article-title":"Crohn's colitis with carcinoma and dysplasia","volume":"7","author":"Warren, R.; Barwick, K.W.","year":"1983","unstructured":"Warren R, Barwick KW. Crohn's colitis with carcinoma and dysplasia. AmJSurgPathol 1983; 7: 151-9.","journal-title":"AmJSurgPathol"},{"key":"ref_20","first-page":"1818","article-title":"Long-term follow-up of patients with Crohn's disease. Relationship between the","volume-title":"clinical pattern and prognosis. Gastroenterology 1985; 88","author":"Farmer, R.G.; Whelan, G.; Fazio, V.W.","unstructured":"Farmer RG, Whelan G, Fazio VW. Long-term follow-up of patients with Crohn's disease. Relationship between the clinical pattern and prognosis. Gastroenterology 1985; 88: 1818-25."},{"key":"ref_21","first-page":"1","article-title":"Barrett's esophagus. Correlation between flow cytometry and histology in detection ofpatients at risk for adenocarcinoma","volume":"93","author":"Reid, B.J.; Haggitt, R.C.; Rubin, C.E.; Rabinovitch, P.S.","year":"1987","unstructured":"Reid BJ, Haggitt RC, Rubin CE, Rabinovitch PS. Barrett's esophagus. Correlation between flow cytometry and histology in detection ofpatients at risk for adenocarcinoma. Gastroenterology 1987; 93: 1-11.","journal-title":"Gastroenterology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF02966119","article-title":"Clinical application of DNA flow cytometry for characterization of colorectal polyps","volume":"15","author":"Hammarberg, C.; Tribukait, B.; Rubio, C.; Slezak, P.","year":"1985","unstructured":"Hammarberg C, Tribukait B, Rubio C, Slezak P. Clinical application of DNA flow cytometry for characterization of colorectal polyps. Acta Endoscopica 1985; 15: 265-73.","journal-title":"Acta Endoscopica"},{"key":"ref_23","series-title":"Proceedings of the International Society of Optical Engineering 1989; 1063","first-page":"170","article-title":"Flow cytometric changes that precede cancer: premalignant gastrointestinal disease. In: New technologies in cytometry","author":"Rabinovitch, P.S.; Burmer, G.C.; Haggitt, R.C.; Levine, D.S.; Rubin, C.E.; Reid, B.J.","unstructured":"Rabinovitch PS, Burmer GC, Haggitt RC, Levine DS, Rubin CE, Reid BJ. Flow cytometric changes that precede cancer: premalignant gastrointestinal disease. In: New technologies in cytometry. Proceedings of the International Society of Optical Engineering 1989; 1063: 170-7."},{"key":"ref_24","first-page":"149","article-title":"Cancer surveillance in ulcerative colitis. Experience over 15 years","volume":"ii:","author":"Lennard-Jones, J.E.; Morson, B.C.; Ritchie, J.K.; Williams, C.B.","year":"1983","unstructured":"Lennard-Jones JE, Morson BC, Ritchie JK, Williams CB. Cancer surveillance in ulcerative colitis. Experience over 15 years. Lancet 1983; ii: 149-52.","journal-title":"Lancet"},{"issue":"23","key":"ref_25","first-page":"20","article-title":"The natural history of inflammatory bowel disease: has there been a change in the last 20 years?","volume":"1988","author":"Softley, A.; Clamp, S.E.; Watkinson, G.; Bouchier, I.A.D.; Myren, J.; de Dombal, F.T.","unstructured":"Softley A, Clamp SE, Watkinson G, Bouchier IAD, Myren J, de Dombal FT. The natural history of inflammatory bowel disease: has there been a change in the last 20 years? Scandj Gastroenterol 1988; 23 (suppl 144): 20-3.","journal-title":"Scandj Gastroenterol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.32.8.900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T03:32:02Z","timestamp":1601091122000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.32.8.900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8,1]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1991,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/gut.32.8.900","relation":{},"ISSN":["0017-5749"],"issn-type":[{"value":"0017-5749","type":"print"}],"subject":[],"published":{"date-parts":[[1991,8,1]]}}}