{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T11:56:42Z","timestamp":1765627002876,"version":"3.48.0"},"reference-count":21,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:p>Placental ferritin is a tumour associated antigen present in the serum of patients with active Hodgkin's and non-Hodgkin's lymphoma, and the serum values fall during remission of the disease. There is no correlation between placental and total blood ferritin values. Because of the strong association between coeliac disease and lymphoma, 19 children with active and 25 with inactive coeliac disease were screened for the presence of placental ferritin. Thirty two children with other intestinal disorders served as controls. Placental ferritin was identified by using a monoclonal antibody in an ELISA procedure. The mean (SEM) placental ferritin value in the control serum was 12.6 (2.4) while the values in serum of patients with active and inactive coeliac disease were 117 (22.8) and 43.8 (10.2) U\/ml respectively. Patients with active coeliac disease differed significantly from both control subjects (p = 0.0004) and those with inactive disease (p = 0.03). Peripheral blood lymphocytes contained no placental ferritin. It was present, however, in lamina propria lymphocytes of intestinal biopsy specimens from active coeliacs. Placental ferritin was also found in some of the better differentiated malignant cells in two patients with adult onset enteropathy associated lymphoma. Placental ferritin is known to have an immunosuppressive effect, and this may be one of the necessary steps in the development of malignancy associated with coeliac disease. Gluten free diet, by reversing this state, may have a role in the prevention of lymphoma.<\/jats:p>","DOI":"10.1136\/gut.32.9.999","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"999-1003","source":"Crossref","is-referenced-by-count":5,"title":["Placental ferritin in coeliac disease: relation to clinical stage, origin, and possible role in the pathogenesis of malignancy."],"prefix":"10.1136","volume":"32","author":[{"given":"G","family":"Dinari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Zahavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Moroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/gut.17.8.612","article-title":"Coeliac disease, gluten free diet and malignancy","volume":"17","author":"Holmes, G.K.T.; Stokes, P.L.; Sorahan, T.M.; Prior, P.; Waterhouse, J.A.M.; Cooke, W.T.","year":"1976","unstructured":"Holmes GKT, Stokes PL, Sorahan TM, Prior P, Waterhouse JAM, Cooke WT. Coeliac disease, gluten free diet and malignancy. Gut 1976; 17: 612-9.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/BF01314465","article-title":"Malignancy in a 19 year experience of adult celiac disease","volume":"24","author":"Selby, W.S.; Gallaher, N.D.","year":"1979","unstructured":"Selby WS, Gallaher ND. Malignancy in a 19 year experience of adult celiac disease. Dig Dis Sci 1979; 24: 684-7.","journal-title":"Dig Dis Sci"},{"key":"ref_3","first-page":"269","article-title":"Coeliac disease and lymphoma","volume":"63","author":"Cooper BT, Read AE","year":"1987","unstructured":"Cooper BT, Read AE. Coeliac disease and lymphoma. QjMed 1987; 63: 269-74.","journal-title":"QjMed"},{"key":"ref_4","first-page":"111","article-title":"Coeliac disease and malignancy","volume":"i:","author":"Swinson, C.M.; Slavin, G.; Cotes, F.C.; Booth, C.C.","year":"1983","unstructured":"Swinson CM, Slavin G, Cotes FC, Booth CC. Coeliac disease and malignancy. Lancet 1983; i: 111-5.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00005176-198401000-00002","article-title":"Is celiac disease a premalignant state?","volume":"3","author":"Keating, J.P.","year":"1984","unstructured":"Keating JP. Is celiac disease a premalignant state? J Pediat Gastroenterol Nutr 1984; 3: 4-5.","journal-title":"J Pediat Gastroenterol Nutr"},{"article-title":"New monoclonal antibody enzymoassay for the specific measurement of placental ferritin isotype in hematologic malignancies. Exp Hematol 1987; 15: 258-62. Placentalferritin in coeliac disease: relation to clinical stage, origin, andpossible role in thepathogenesis ofmalignancy","author":"Moroz, C.; Bessler, H.; Lurie, Y.; Shaklai, M.","key":"ref_6","unstructured":"Moroz C, Bessler H, Lurie Y, Shaklai M. New monoclonal antibody enzymoassay for the specific measurement of placental ferritin isotype in hematologic malignancies. Exp Hematol 1987; 15: 258-62. Placentalferritin in coeliac disease: relation to clinical stage, origin, andpossible role in thepathogenesis ofmalignancy"},{"key":"ref_7","first-page":"903","article-title":"Is coeliac disease a premalignant state?","volume":"ii:","author":"Moroz, C.; Marcus, H.; Zahavi, I.; Dinari, G.","year":"1988","unstructured":"Moroz C, Marcus H, Zahavi I, Dinari G. Is coeliac disease a premalignant state? Lancet 1988; ii: 903-4.","journal-title":"Lancet"},{"key":"ref_8","first-page":"461","article-title":"Diagnostic criteria in coeliac disease","volume":"59","author":"Meeuwisse, G.W.","year":"1970","unstructured":"Meeuwisse GW. Diagnostic criteria in coeliac disease. Acta PaediatrScand 1970; 59: 461-3.","journal-title":"Acta PaediatrScand"},{"key":"ref_9","first-page":"702","article-title":"Difference in the placental ferritin levels measured by a specific monoclonal antibody enzymoassay in preterm and term delivery. Clin Exp Immunol","volume":"69","author":"Moroz, C.; Bessler, H.; Sirota, L.; Dulitzky, F.; Djaldetti, M.","year":"1987","unstructured":"Moroz C, Bessler H, Sirota L, Dulitzky F, Djaldetti M. Difference in the placental ferritin levels measured by a specific monoclonal antibody enzymoassay in preterm and term delivery. Clin Exp Immunol 1987; 69: 702-6."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00005792-198007000-00002","article-title":"Celiac disease and malignancy","volume":"59","author":"Cooper, B.T.; Holmes, G.K.J.; Ferguson, R.; Cooke, W.T.","year":"1980","unstructured":"Cooper BT, Holmes GKJ, Ferguson R, Cooke WT. Celiac disease and malignancy. Medicine 1980; 59: 249-61.","journal-title":"Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0140-6736(78)90004-1","article-title":"Intestinal lymphoma associated with malabsorption","volume":"i:","author":"Isaacson, P.; Wright, D.H.","year":"1978","unstructured":"Isaacson P, Wright DH. Intestinal lymphoma associated with malabsorption. Lancet 1978; i: 67-70.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.7326\/0003-4819-104-1-44","article-title":"T-cell intestinal lymphoma associated with celiac sprue","volume":"104","author":"Loughran, T.P.; Kolin, M.E.; Deeg, H.J.","year":"1986","unstructured":"Loughran TP, Kolin ME, Deeg HJ. T-cell intestinal lymphoma associated with celiac sprue. Ann Intern Med 1986; 104: 44-7.","journal-title":"Ann Intern Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/jcp.39.1.8","article-title":"Immunophenotype analysis of malignant histiocytosis of the intestine","volume":"39","author":"Salter, D.M.; Krajewski, A.S.; Dewar, A.E.","year":"1986","unstructured":"Salter DM, Krajewski AS, Dewar AE. Immunophenotype analysis of malignant histiocytosis of the intestine. J Clin Pathol 1986; 39: 8-15.","journal-title":"J Clin Pathol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/1097-0142(19840701)54:1<84::AID-CNCR2820540118>3.0.CO;2-T","article-title":"Ferritin bearing lymphocytes in the diagnosis of breast cancer","volume":"54","author":"Moroz, C.; Kan, M.; Chaimoff, C.; Marcus, H.; Kupfer, B.; Cuckle, S.","year":"1984","unstructured":"Moroz C, Kan M, Chaimoff C, Marcus H, Kupfer B, Cuckle S. Ferritin bearing lymphocytes in the diagnosis of breast cancer. Cancer 1984; 54: 84-9.","journal-title":"Cancer"},{"key":"ref_15","first-page":"11","article-title":"Isoferritin in HIV infections: relation to clinical stage, CD8 lymphocyte binding and the pathogenesis of AIDS","volume":"3","author":"Moroz, C.; Misrock, S.L.; Siegal, F.P.S.","year":"1989","unstructured":"Moroz C, Misrock SL, Siegal FPS. Isoferritin in HIV infections: relation to clinical stage, CD8 lymphocyte binding and the pathogenesis of AIDS. AIDS 1989; 3: 11-6.","journal-title":"AIDS"},{"key":"ref_16","first-page":"775","article-title":"Intraepithelial, lamina propria and Peyer's patch lymphocytes of the rat small intestine: isolation and characterization in terms of immunoglobulin markers and receptors for monoclonal antibodies","volume":"45","author":"Lyscom, N.; Brueton, M.J.","year":"1982","unstructured":"Lyscom N, Brueton MJ. Intraepithelial, lamina propria and Peyer's patch lymphocytes of the rat small intestine: isolation and characterization in terms of immunoglobulin markers and receptors for monoclonal antibodies. Immunology 1982; 45: 775-83.","journal-title":"Immunology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/gut.28.8.995","article-title":"Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease","volume":"28","author":"KagnoffMF, Paterson Y.J.; PJ, Kumar; DD, Kasarda; FR, Carbone; DJ, Unsworth","year":"1987","unstructured":"KagnoffMF, Paterson YJ, Kumar PJ, Kasarda DD, Carbone FR, Unsworth DJ, et al. Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease. Gut 1987; 28: 995-1001.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2141.1985.tb07331.x","article-title":"Differential effect of isolated placental isoferritin on in-vitro T lymphocyte function","volume":"59","author":"Matzner, Y.; Konijin, A.M.; Shlomai, Z.; Ben-Basat, H.","year":"1985","unstructured":"Matzner Y, Konijin AM, Shlomai Z, Ben-Basat H. Differential effect of isolated placental isoferritin on in-vitro T lymphocyte function. BrJ Haematol 1985; 59: 443-8.","journal-title":"BrJ Haematol"},{"key":"ref_19","first-page":"1305","article-title":"Suppressor-cell activity in coeliac disease induced by alphagliadin, a dietary antigen","volume":"ii:","author":"O'Farrelly, C.; Whelan, C.A.; Feighery, C.F.; Weir, D.G.","year":"1984","unstructured":"O'Farrelly C, Whelan CA, Feighery CF, Weir DG. Suppressor-cell activity in coeliac disease induced by alphagliadin, a dietary antigen. Lancet 1984; ii: 1305-7.","journal-title":"Lancet"},{"issue":"40","key":"ref_20","first-page":"55","article-title":"Coeliac disease: ecology, life history and management","volume":"1986","author":"McNicholl, B.","unstructured":"McNicholl B. Coeliac disease: ecology, life history and management. Hum Nunr Appl Nutr 1986; 40A (suppl 1): 55-9.","journal-title":"Hum Nunr Appl Nutr"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/gut.30.3.333","article-title":"Malignancy in coeliac disease - effect of a gluten-free diet","volume":"30","author":"Holmes, G.K.T.; Prior, P.; Lane, M.R.; Pope, D.; Allan, R.N.","year":"1989","unstructured":"Holmes GKT, Prior P, Lane MR, Pope D, Allan RN. Malignancy in coeliac disease - effect of a gluten-free diet. 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