{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:09:30Z","timestamp":1759342170122,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>A patient presenting with predominantly gastrointestinal symptoms and a history of myocardial infarction was found to have ascites, hepatosplenomegaly, para-aortic lymphadenopathy, thrombocytosis, and a paraproteinaemia. A jejunal biopsy specimen showed lymphangiectasia and histology of the spleen and lymph nodes showed angiofollicular hyperplasia or Castleman's disease of the hyaline vascular type. This association has not previously been described and, moreover, systemic symptoms are unusual in this variant of Castleman's disease.<\/jats:p>","DOI":"10.1136\/gut.33.1.135","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"135-137","source":"Crossref","is-referenced-by-count":7,"title":["Intestinal lymphangiectasia associated with angiofollicular lymph node hyperplasia (Castleman's disease)."],"prefix":"10.1136","volume":"33","author":[{"given":"S F","family":"Moss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Mulnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I G","family":"McGill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,1,1]]},"reference":[{"key":"ref_1","first-page":"598","volume-title":"Textbook of gastroenterology","author":"In, Strober W.","year":"1984","unstructured":"Strober W. In: Bouchier IAD, Allan RN, Hodgson HJF, Keighley MRB, eds. Textbook of gastroenterology. London: Baillire Tindall, 1984: 598-615."},{"key":"ref_2","first-page":"164356","article-title":"Intestinal lymphangiectasia: a protein losing enteropathy with hypogammaglobulinaemia, lymphocytopaenia and impaired homograft rejection","volume":"46","author":"Strober, W.; Wochner, R.D.; Carbone, P.P.; Waldmann, T.A.","year":"1967","unstructured":"Strober W, Wochner RD, Carbone PP, Waldmann TA. Intestinal lymphangiectasia: a protein losing enteropathy with hypogammaglobulinaemia, lymphocytopaenia and impaired homograft rejection. i Clin Invest 1967; 46: 164356.","journal-title":"i Clin Invest"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/1097-0142(195607\/08)9:4<822::AID-CNCR2820090430>3.0.CO;2-4","article-title":"Localised mediastinal lymph node hyperplasia resembling thymoma","volume":"9","author":"Castleman, B.; Iverson, L.; Menendez, V.P.","year":"1956","unstructured":"Castleman B, Iverson L, Menendez VP. Localised mediastinal lymph node hyperplasia resembling thymoma. Cancer 1956; 9: 822-30.","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/1097-0142(197203)29:3<670::AID-CNCR2820290321>3.0.CO;2-#","article-title":"Hyaline vascular and plasma cell types of giant lymph node hyperplasia of mediastinum and other locations","volume":"29","author":"Keller, A.R.; Hochholzer, L.; Castleman, B.","year":"1972","unstructured":"Keller AR, Hochholzer L, Castleman B. Hyaline vascular and plasma cell types of giant lymph node hyperplasia of mediastinum and other locations. Cancer 1972; 29: 670-83.","journal-title":"Cancer"},{"key":"ref_5","first-page":"1","article-title":"The local mucosal immune system in intestinal lymphangiectasia","volume":"26","author":"Myszor, M.F.; Davidson, A.; Hodgson, H.J.F.","year":"1988","unstructured":"Myszor MF, Davidson A, Hodgson HJF. The local mucosal immune system in intestinal lymphangiectasia. J Clin Lab Immunol 1988; 26: 1-3.","journal-title":"J Clin Lab Immunol"},{"key":"ref_6","first-page":"191","article-title":"Submucous lymphatic cysts of the small intestine","volume":"91","author":"Steinar, A.; Gundersen, R.","year":"1983","unstructured":"Steinar A, Gundersen R. Submucous lymphatic cysts of the small intestine. Acta Pathol Microbiol Scand [B] 1983; 91: 191-4.","journal-title":"Acta Pathol Microbiol Scand [B]"},{"key":"ref_7","first-page":"379","article-title":"Angiofollicular lymph node hyperplasia and peripheral neuropathy: association with monoclonal gammopathy","volume-title":"Mayo Clin Proc","volume":"57","author":"Hineman, V.L.; Phyliky, R.L.; Banks, P.M.","year":"1982","unstructured":"Hineman VL, Phyliky RL, Banks PM. Angiofollicular lymph node hyperplasia and peripheral neuropathy: association with monoclonal gammopathy. Mayo Clin Proc 1982; 57: 379-82."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0022-510X(89)90027-0","article-title":"Peripheral neuropathy associated with Castleman's disease","volume":"89","author":"Donaghy, M.; Hall, P.A.; Gawler, J.","year":"1989","unstructured":"Donaghy M, Hall PA, Gawler J, et al. Peripheral neuropathy associated with Castleman's disease. J Neurol Sci 1989; 89: 253-67.","journal-title":"J Neurol Sci"},{"key":"ref_9","first-page":"606","article-title":"Case records of the Massachusetts General Hospital","volume":"316","year":"1987","unstructured":"Case records of the Massachusetts General Hospital. N Engil Med 1987; 316: 606-18.","journal-title":"N Engil Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/pgmj.65.760.108","article-title":"Angiofollicular lymph node hyperplasia with amyloidosis","volume":"65","author":"West, K.P.; Morgan, D.A.; Lauder, I.","year":"1989","unstructured":"West KP, Morgan DA, Lauder I. Angiofollicular lymph node hyperplasia with amyloidosis. Postgrad Med J 1989; 65: 108-11.","journal-title":"Postgrad Med J"},{"key":"ref_11","first-page":"543","article-title":"Antierythropoietin antibody in hyperviscosity syndrome associated with giant lymph node hyperplasia (Castleman's disease)","volume":"74","author":"Steinberg, J.L.; Huang, P.L.; Ljubich, P.; Lee-Huang, S.","year":"1990","unstructured":"Steinberg JL, Huang PL, Ljubich P, Lee-Huang S. Antierythropoietin antibody in hyperviscosity syndrome associated with giant lymph node hyperplasia (Castleman's disease). BrJHaematol 1990; 74: 543-44.","journal-title":"BrJHaematol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-2559.1989.tb02162.x","article-title":"An immunohistochemical and genotypic study ofthe plasma cell form of Castleman's disease","volume":"14","author":"Hall, P.A.; Donaghy, M.; Cotter, F.E.; Stansfeld, A.G.; Levison, D.A.","year":"1989","unstructured":"Hall PA, Donaghy M, Cotter FE, Stansfeld AG, Levison DA. An immunohistochemical and genotypic study ofthe plasma cell form of Castleman's disease. Histopathology 1989; 14: 333-46.","journal-title":"Histopathology"},{"key":"ref_13","first-page":"84","article-title":"Clonal rearrangement for immunoglobulin T cell receptor genes in systemic Castleman's disease: association with Epstein-Barr virus","volume":"131","author":"Hanson, C.A.; Frizzera, G.; Patton, D.F.","year":"1988","unstructured":"Hanson CA, Frizzera G, Patton DF, et al. Clonal rearrangement for immunoglobulin T cell receptor genes in systemic Castleman's disease: association with Epstein-Barr virus. AmJ Pathol 1988; 131: 84-91.","journal-title":"AmJ Pathol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/1097-0142(19890115)63:2<260::AID-CNCR2820630210>3.0.CO;2-Y","article-title":"Giant lymph node hyperplasia (Castleman's disease) with spontaneous production of high levels of B cell differentiation factor activity","volume":"63","author":"Yabuhara, A.; Yanagisawa, M.; Murata, T.","year":"1989","unstructured":"Yabuhara A, Yanagisawa M, Murata T, et al. Giant lymph node hyperplasia (Castleman's disease) with spontaneous production of high levels of B cell differentiation factor activity. Cancer 1989; 63: 260-5.","journal-title":"Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1182\/blood.V74.4.1360.1360","article-title":"Pathogenic significance of interleukin-6 (IL-6\/BSF-2) in Castleman's disease","volume":"74","author":"Yoshizaki, K.; Matsuda, T.; Nishimoto, N.","year":"1989","unstructured":"Yoshizaki K, Matsuda T, Nishimoto N, et al. Pathogenic significance of interleukin-6 (IL-6\/BSF-2) in Castleman's disease. Blood 1989; 74: 1360-7.","journal-title":"Blood"},{"key":"ref_16","first-page":"603","article-title":"Development of vascular neoplasia in Castleman's disease: report of 7 cases","volume":"14","author":"Gerald, W.; Kostianovsky, M.; Rosai, J.","year":"1990","unstructured":"Gerald W, Kostianovsky M, Rosai J. Development of vascular neoplasia in Castleman's disease: report of 7 cases. AmJSurg Pathol 1990; 14: 603-14.","journal-title":"AmJSurg Pathol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0046-8177(85)80002-2","article-title":"Castleman's disease: more questions than answers","volume":"16","author":"Frizzera, G.","year":"1985","unstructured":"Frizzera G. Castleman's disease: more questions than answers. Hum Pathol 1985; 16: 202-5.","journal-title":"Hum Pathol"},{"key":"ref_18","first-page":"566","article-title":"Gastric Castleman's disease with a lupus-like circulating anticoagulant","volume":"84","author":"Yebra, M.; Vargas, J.A.; Menendez, V.P.","year":"1989","unstructured":"Yebra M, Vargas JA, Menendez VP, et al. Gastric Castleman's disease with a lupus-like circulating anticoagulant. Am J Gastroenterol 1989; 84: 566-70.","journal-title":"Am J Gastroenterol"},{"key":"ref_19","first-page":"884","article-title":"Castleman's tumour masquerading as a pancreatic neoplasm","volume":"106","author":"LeVan, T.A.; Clifford, S.; Staren, E.D.","year":"1989","unstructured":"LeVan TA, Clifford S, Staren ED. Castleman's tumour masquerading as a pancreatic neoplasm. Surgery 1989; 106: 884-7.","journal-title":"Surgery"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.1.135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T20:36:36Z","timestamp":1757277396000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.1.135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1992,1,1]]},"published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1136\/gut.33.1.135"],"URL":"https:\/\/doi.org\/10.1136\/gut.33.1.135","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}